Results 21 to 30 of about 1,682,982 (408)
Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]
, 2018 The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Bye, Alex P. +6 more
core +4 more sources
Mediators of Inflammation, 2019 Platelet size has been demonstrated to reflect platelet activity and seems to be a useful predictive and prognostic biomarker of cardiovascular events. It is associated with a variety of prothrombotic and proinflammatory diseases.
Aleksandra Korniluk +4 more
semanticscholar +1 more source
Haematologica, 2020 Platelet adhesion to the sub-endothelial matrix and damaged endothelium occurs through a multi-step process mediated in the initial phase by glycoprotein Ib binding to von Willebrand factor (vWF), which leads to the subsequent formation of a platelet ...
Simona Stivala +7 more
doaj +1 more source
Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]
, 2002 Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E. +3 more
core +1 more source
Platelets and Anti-platelet Therapy
Journal of Pharmacological Sciences, 2003 Platelets play a central role in the hemostatic process and consequently are similarly involved in the pathological counterpart, thrombosis. They adhere to various subendothelial proteins, exposed either by injury or disease, and subsequently become activated by the thrombogenic surface or locally produced agonists.
Archibald McNicol, Sara J. Israels
openaire +4 more sources
F1000Research, 2018 European and UK legislation requires all animal procedures to be conducted with consideration to reduction, refinement and replacement. In this review, 3Rs developments are discussed in the field of platelet biology and thromboembolism. Platelet research
Kirk A. Taylor, Michael Emerson
doaj +1 more source
Medicina, 2020 The demand of platelet transfusions is steadily growing worldwide, inter-donor variation, donor dependency, or storability/viability being the main contributing factors to the current global, donor-dependent platelet concentrate shortage concern.
Patricia Martínez-Botía +3 more
doaj +1 more source
Role of platelet-derived growth factors in physiology and medicine.
Genes & Development, 2008 Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and PDGFRs in animal development have revealed roles for PDGFR-
Johanna Andrae, R. Gallini, C. Betsholtz
semanticscholar +1 more source
Role of P-selectin in platelet sequestration in pulmonary capillaries during endotoxemia [PDF]
, 2006 Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia.
Alwin Eduard Goetz +37 more
core +1 more source
ROS in Platelet Biology: Functional Aspects and Methodological Insights
International Journal of Molecular Sciences, 2020 Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet functions. Platelet activation determines a drastic change in redox balance and in platelet metabolism. Indeed, several signaling pathways have been demonstrated to
E. Masselli +7 more
semanticscholar +1 more source