Results 21 to 30 of about 1,180,803 (314)

Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors

Clinical and Applied Thrombosis/Hemostasis, 2019
In nucleated cells, the extrinsic pathway of the programmed cell death (apoptosis) is triggered by interaction of death ligands of the tumor necrosis factor superfamily with the death receptors on external cell surface membrane.
Valery Leytin PhD, Armen V. Gyulkhandanyan PhD, John Freedman MD   +2 more
doaj   +1 more source

ROS in Platelet Biology: Functional Aspects and Methodological Insights

International Journal of Molecular Sciences, 2020
Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet functions. Platelet activation determines a drastic change in redox balance and in platelet metabolism. Indeed, several signaling pathways have been demonstrated to
E. Masselli, Giulia Pozzi, M. Vaccarezza, P. Mirandola, D. Galli, M. Vitale, C. Carubbi, G. Gobbi   +7 more
semanticscholar   +1 more source

Nanoparticle biointerfacing via platelet membrane cloaking

Nature, 2015
Development of functional nanoparticles can be encumbered by unanticipated material properties and biological events, which can affect nanoparticle effectiveness in complex, physiologically relevant systems.
C. J. Hu, Ronnie H. Fang, Kuei‐Chun Wang, Brian T. Luk, Soracha Thamphiwatana, Diana Dehaini, P. Nguyen, Pavimol Angsantikul, Cindy Wen, Ashley V. Kroll, Cody W. Carpenter, M. Ramesh, V. Qu, Sherrina H. Patel, Jie Zhu, W. Shi, F. Hofman, Thomas C Chen, Weiwei Gao, Kang Zhang, S. Chien, Liangfang Zhang   +21 more
semanticscholar   +1 more source

Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation

TH Open
Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation.
Jinmi Zou, Siyu Sun, Ilaria De Simone, Hugo ten Cate, Philip G. de Groot, Bas de Laat, Mark Roest, Johan W.M. Heemskerk, Frauke Swieringa   +8 more
doaj   +1 more source

Mutation spectrum and genotype‐phenotype correlations in a large French cohort of MYH9‐Related Disorders

Molecular Genetics & Genomic Medicine, 2014
MYH9‐Related Disorders are a group of rare autosomal dominant platelet disorders presenting as nonsyndromic forms characterized by macrothrombocytopenia with giant platelets and leukocyte inclusion bodies or as syndromic forms combining these ...
Béatrice Saposnik, Sylvie Binard, Odile Fenneteau, Alan Nurden, Paquita Nurden, Marie‐Françoise Hurtaud‐Roux, Nicole Schlegel, the French MYH9 network   +7 more
doaj   +1 more source

Neutrophil extracellular traps induce aggregation of washed human platelets independently of extracellular DNA and histones

Cell Communication and Signaling, 2018
Background The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host defence against pathogens.
Omar Elaskalani, Norbaini Binti Abdol Razak, Pat Metharom   +2 more
doaj   +1 more source

Fibrinogen Mitigates Prion-Mediated Platelet Activation and Neuronal Cell Toxicity

Frontiers in Cell and Developmental Biology, 2022
Prion peptide (PrP) misfolds to infectious scrapie isoform, the β pleat-rich insoluble fibrils responsible for neurodegeneration and fatal conformational diseases in humans.
Deepa Gautam, Deepa Gautam, Jyotsna Kailashiya, Arundhati Tiwari, Rameshwar Nath Chaurasia, Gowtham K. Annarapu, Prasenjit Guchhait, Debabrata Dash   +7 more
doaj   +1 more source

Restrained glycoprotein VI-induced platelet signaling by tyrosine protein phosphatases independent of phospholipase Cγ2

Bleeding, Thrombosis and Vascular Biology, 2023
The platelet collagen receptor glycoprotein VI (GPVI) signals to activation of phospholipase Cγ2 (PLCγ2) and phosphoinositide 3-kinases (PI3K), causing platelet activation and aggregation.
Jingnan Huang, Delia I. Fernández, Jinmi Zou, Xueqing Wang, Johan W.M. Heemskerk, Ángel García   +5 more
doaj   +1 more source

Randomized Trial of Platelet‐Transfusion Thresholds in Neonates

New England Journal of Medicine, 2019
BACKGROUND Platelet transfusions are commonly used to prevent bleeding in preterm infants with thrombocytopenia. Data are lacking to provide guidance regarding thresholds for prophylactic platelet transfusions in preterm neonates with severe ...
A. Curley, S. Stanworth, K. Willoughby, S. F. Fustolo-Gunnink, V. Venkatesh, C. Hudson, A. Deary, R. Hodge, V. Hopkins, Beatriz Lopez Santamaria, A. Mora, C. Llewelyn, A. D’Amore, R. Khan, W. Onland, E. Lopriore, Karin Fijnvandraat, H. New, P. Clarke, T. Watts   +19 more
semanticscholar   +1 more source

TNF-alpha driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging.

Blood, 2019
Aging and chronic inflammation are independent risk factors for the development of atherothrombosis and cardiovascular disease. We hypothesized that aging-associated inflammation promotes the development of platelet hyperreactivity and increases ...
Pavel Davizon-Castillo, B. McMahon, S. Águila, D. Bark, K. Ashworth, A. Allawzi, Robert A. Campbell, E. Montenont, T. Nemkov, A. D’Alessandro, Nathan Clendenen, L. Shih, Natalie A Sanders, K. Higa, Allaura Cox, Zavelia Padilla-Romo, Giovanni Hernandez, E. Wartchow, G. D. Trahan, E. Nozik-Grayck, Kenneth L. Jones, E. Pietras, J. DeGregori, M. Rondina, J. Di Paola   +24 more
semanticscholar   +1 more source