Results 71 to 80 of about 504,301 (176)

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis

Nature Communications, 2018
Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggregation ...
Xiaohong Ruby Xu, Yiming Wang, Reheman Adili, Lining Ju, Christopher M. Spring, Joseph Wuxun Jin, Hong Yang, Miguel A. D. Neves, Pingguo Chen, Yan Yang, Xi Lei, Yunfeng Chen, Reid C. Gallant, Miao Xu, Hailong Zhang, Jina Song, Peifeng Ke, Dan Zhang, Naadiya Carrim, Si-Yang Yu, Guangheng Zhu, Yi-Min She, Terry Cyr, Wenbin Fu, Guoqing Liu, Philip W. Connelly, Margaret L. Rand, Khosrow Adeli, John Freedman, Jeffrey E. Lee, Patrick Tso, Patrizia Marchese, W. Sean Davidson, Shaun P. Jackson, Cheng Zhu, Zaverio M. Ruggeri, Heyu Ni   +36 more
doaj   +1 more source

Generation of Advanced Blood–Brain Barrier Spheroids Using Human‐Induced Pluripotent Stem Cell‐Derived Brain Capillary Endothelial‐Like Cells

Advanced Biology, EarlyView.
In this article, the establishment and characterization of a self‐assembled 3D BBB spheroid model using human induced pluripotent stem cell (hiPSC)‐derived and primary cells is reported. Spheroids demonstrate in‐vivo like tight junction ultrastructure and, in comparison to 2D mono‐cultures, higher transcript expression of BBB specific genes.
Sanjana Mathew‐Schmitt, Sabrina Oerter, Evelin Reitenbach, Sabine Gätzner, Alevtina Höchner, Heinz‐Georg Jahnke, Jörg Piontek, Winfried Neuhaus, Andreas Brachner, Marco Metzger, Antje Appelt‐Menzel   +10 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Confetti Ordering by Polymer Brushes [PDF]

arXiv, 2015
I consider the ordering of dilute platelet additives when incorporated into an end-grafted polymer brush. The competition between wetting interactions and the anisotropic stress environment of the interior of the brush causes these platelet additives to either remain suspended at the outer edge of the brush laying flat against the brush surface (as ...
arxiv  

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

A Non-Invasive Strategy for Neonatal Alloimmune Thrombocytopenia Diagnosis: Newborn Platelet Genotyping with Buccal Swabs

International Journal of Neonatal Screening, 2016
Neonatal alloimmune thrombocytopenia results from the maternal immune response against fetal-specific antigens inherited from the father. The diagnosis is ascertained only when the maternal alloantibody and the offending antigen present in the newborn ...
Gérald Bertrand, Cécile Kaplan
doaj   +1 more source

Revealing the γ′ and γ″ Phase Fractions of Additively Manufactured and Differently Heat‐Treated Nickel‐Base Superalloy IN718 by Atom Probe Tomography and Their Impact on Mechanical Properties

Advanced Engineering Materials, EarlyView.
Additive manufacturing is a promising route for the production of Ni‐base superalloys for turbine applications, such as Inconel 718. Nonetheless, it induces various changes in the microstructure and performance of these materials. One such change is the incidence of the δ‐Ni3Nb phase, whose impact on microstructure, aging precipitate fractions, and ...
Guilherme Maziero Volpato, Jan Vollhüter, Benedikt Diepold, Martin Sebastian Meier, Martin Pröbstle, Mathias Göken, Thomas Niendorf, Peter Felfer, Steffen Neumeier   +8 more
wiley   +1 more source

Electrically Insulating Electromagnetic Interference Shielding Materials: A Perspective

Advanced Functional Materials, EarlyView.
Developing electromagnetic interference (EMI) shielding materials with inherent electrical insulation and high EMI shielding effectiveness is challenging but important for electronic applications. This perspective summarizes the recent advancements in designing electrically insulating EMI shielding materials and discusses the underlying mechanisms of ...
Ji Liu, Valeria Nicolosi
wiley   +1 more source

Comprehensive characterization of platelet function in dogs with hyperadrenocorticism

Haematologica
Hyperadrenocorticism (HAC) leads to a hypercoagulable state and contributes to the risk of thromboembolic disease. Hypercoagulation in HAC occurs in both humans and dogs.
Sanggu Kim, Dohee Lee, Preeti Kumari Chaudhary, Hakhyun Kim, Byeong-Teck Kang, Soochong Kim   +5 more
doaj   +1 more source

A Novel Protein‐Polysaccharide Oral Nanoemulsion Targeting Activated Hepatic Stellate Cells to Enhance the Therapeutic Effect of Pirfenidone on Fibrosis After Transarterial Chemoembolization for Liver Cancer

Advanced Functional Materials, EarlyView.
Transarterial Chemoembolization (TACE) may aggravate liver fibrosis. In this study, a novel oral targeting nanoemulsion is fabricated to enhance the therapeutic effect of antifibrotic drug‐pirfenidone (PFD) on fibrosis after TACE. Studies have shown that PFD nanoemulsion can enhance the oral liver targeting effect of PFD, and effectively improve the ...
Zhimei Cheng, Shan Xu, Yi Lei, Huizhou He, Runbin Sun, Xingle Jin, Cheneryu Huang, Yuhao Zheng, Jianqing Peng, Lei Tang, Peng Luo, Yi Chen, Shuai Zhang   +12 more
wiley   +1 more source