Results 71 to 80 of about 1,067,744 (311)

Prion protein fragment (106–126) activates NLRP3 inflammasome and promotes platelet-monocyte/neutrophil interactions, potentially contributing to an inflammatory state

Frontiers in Cell and Developmental Biology
IntroductionPrion diseases are neurodegenerative disorders where infectious prion proteins (PrP) featuring an amyloidogenic amino acid sequence, PrP (106–126), accumulate in the brain leading to neuroinflammation while it can also access circulation by ...
Rashmi Verma, Jyotsna Kailashiya, Avijit Mukherjee, Rameshwar Nath Chaurasia, Debabrata Dash   +4 more
doaj   +1 more source

Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets [PDF]

, 2018
Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis.
Birnbaumer, Lutz, Bissinger, Rosi, Cao, Hang, Gawaz, Meinrad, Lang, Elisabeth, Lang, Florian, Leiss, Veronika, Nürnberg, Bernd, Pelzl, Lisann, Pieske, Burkert, Qadri, Syed M., Umbach, Anja T., Voelkl, Jakob   +12 more
core   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Impact of walkability with regard to physical activity in the prevention of diabetes

Geospatial Health, 2017
Walkability, a component of urban design intended to facilitate pedestrian traffic, depends on parameters associated with the connectivity of routes, population density and availability of destinations in the neighbourhood.
Carlos Mena, César Sepúlveda, Yony Ormazábal, Eduardo Fuentes, Iván Palomo   +4 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Intraoperative blood transfusions in highly alloimmunized patients undergoing orthotopic liver transplantation. [PDF]

, 1989
Intraoperative blood requirements were analyzed in patients undergoing primary orthotopic liver transplantation and divided into two groups on the basis of panel reactive antibody of pretransplant serum measured by lymphocytotoxicity testing.
Duquesnoy, RJ, Esquivel, CD, Kang, YG, Marino, IR, Starzl, TE, Weber, T   +5 more
core   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

PB2619: THE IMPACT OF ITP-DIRECTED TREATMENT ON FATIGUE AMONG CHILDREN AND ADOLESCENTS WITH CHRONIC ITP: DATA FROM THE ITP NATURAL HISTORY STUDY REGISTRY

HemaSphere, 2023
Jennifer Diraimo, Caroline Kruse, Alexandra Kruse, Kevin Doyoon Won, Rachael F. Grace   +4 more
doaj   +1 more source

Non-canonical non-genomic morphogen signaling in anucleate platelets: a critical determinant of prothrombotic function in circulation

Cell Communication and Signaling
Circulating platelets derived from bone marrow megakaryocytes play a central role in thrombosis and hemostasis. Despite being anucleate, platelets express several proteins known to have nuclear niche.
Paresh P. Kulkarni, Mohammad Ekhlak, Debabrata Dash   +2 more
doaj   +1 more source

Relevance and limitations of clinical follow-up in a pharmacokinetic study on direct oral anticoagulants

Frontiers in Pharmacology
IntroductionDirect oral anticoagulants (DOACs), including apixaban and rivaroxaban, are widely prescribed for the prevention of cardioembolic stroke and the treatment of venous thromboembolism.
Jean Terrier, Jean Terrier, Jean Terrier, Pauline Gosselin, Pauline Gosselin, Christophe Combescure, Pierre Fontana, Pierre Fontana, Youssef Daali, Youssef Daali, Jean-Luc Reny, Jean-Luc Reny, Chantal Alves, Frederic Gaspar, Monia Guidi, Lenoir Camille, Victoria Rollason   +16 more
doaj   +1 more source