Results 31 to 40 of about 991,613 (310)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway[S]

Journal of Lipid Research, 2013
Platelet-activating factor (PAF), 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine, is a potent phospholipid mediator and has been reported to be localized in atherosclerotic plaque.
Yun H. Kim, Seung J. Lee, Kyo W. Seo, Jin U. Bae, So Y. Park, Eun K. Kim, Sun S. Bae, Jae H. Kim, Chi D. Kim   +8 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Perbedaan Kadar Platelet Activating Factor Plasma antara Penderita Demam Berdarah Dengue dan Demam Dengue

Majalah Kedokteran Bandung, 2013
Dengue virus infection can manifest as dengue fever and, more severely, as dengue hemorrhagic fever. Their pathogenesis until now is not fully understood.
Djatnika Setiabudi, Budi Setiabudiawan, Ida Parwati, Herry Garna   +3 more
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

The PON1 M55L gene polymorphism is associated with reduced HDL-associated PAF-AH activity

Journal of Lipid Research, 2003
The platelet-activating factor acetylhydrolase activity associated with high density lipoprotein (HDL-PAF-AH) may substantially contribute to the antioxidant, anti-inflammatory, and overall antiatherogenic effects of HDL.
Anna I. Kakafika, Stavroula Xenofontos, Vasilis Tsimihodimos, Afroditi P. Tambaki, Evangelia S. Lourida, Rigas Kalaitzidis, Marios A. Cariolou, Moses Elisaf, Alexandros D. Tselepis   +8 more
doaj   +1 more source

Prolonged Exposure to Platelet Activating Factor Transforms Breast Epithelial Cells

Frontiers in Genetics, 2021
Lipid species are known to have various biological functions owing to their structural differences, and each of them possesses a specific role to play depending upon their location and distribution in the cell. Some of these lipids interact with proteins
Vaishali Chakravarty, Libi Anandi, K. A. Ashiq, K. Abhijith, Rintu Umesh, Mayurika Lahiri   +5 more
doaj   +1 more source

The release of platelet-activating factor from human endothelial cells in culture.

Journal of Immunology, 1983
The release of platelet-activating factor (PAF) from stimulated human endothelial cells (HEC) cultured from normal term, umbilical cord veins is described.
G. Camussi, M. Aglietta, F. Malavasi, C. Tetta, W. Piacibello, F. Sanavio, F. Bussolino   +6 more
semanticscholar   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils.

Journal of Immunology, 1979
Platelet activating factor (PAF) released in vivo into the plasmas of rabbits during development of IgE-induced systemic anaphylactic shock had indistinguishable physicochemical and functional properties when compared with PAF released in vitro from ...
R. Neal Pinckard, Richard S. Farr, Donald J. Hanahan   +2 more
semanticscholar   +1 more source