Platelet-activating factor acetylhydrolase in primary antiphospholipid syndrome [PDF]
, 2018 publishersversionpublishe
Ames, Paul R J +3 more
core +1 more source
von Willebrand Factor unfolding mediates platelet deposition in a model of high-shear thrombosis [PDF]
, 2022 Thrombosis under high-shear conditions is mediated by the mechanosensitive blood glycoprotein von Willebrand Factor (vWF). vWF unfolds in response to strong flow gradients and facilitates rapid recruitment of platelets in flowing blood. While the thrombogenic effect of vWF is well recognized, its conformational response in complex flows has largely ...
arxiv +1 more source
Production of platelet-activating factor by chick retina. [PDF]
, 1986 In the present study it is demonstrated that platelet-activating factor (PAF) was produced by chick retinas, upon stimulation with neurotransmitters such as acetylcholine (ACh), dopamine, or with calcium ionophore A23187, but not upon stimulation with ...
Ciro Tetta +4 more
core +1 more source
Molecules, 2019 Ginkgolides are the major active component of Ginkgo biloba for inhibition of platelet activating factor receptor. An azide-alkyne Huisgen cycloaddition reaction was used to introduce a triazole nucleus into the target ginkgolide molecules.
Jian Cui +5 more
doaj +1 more source
The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. [PDF]
, 2012 BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease.
Fehrenbach, Melane L +8 more
core +2 more sources
Molecular Biology of the Cell, 2010 Results from these studies reveal that some strains of Gram-positive bacteria exploit hypoxia-inducible factor-regulated platelet-activating factor receptor as a means for translocation through intestinal epithelial cells.
S. Keely +6 more
semanticscholar +1 more source
Three-dimensional Multiscale Model of Deformable Platelets Adhesion to Vessel Wall in Blood Flow [PDF]
, 2013 When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering and rolling on the injured endothelium is a critical initial step in blood clot formation.
arxiv +1 more source
Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]
, 2018 Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A. +6 more
core +1 more source
Taiwanese Journal of Obstetrics & Gynecology, 2016 Objective: The aim of this study was to investigate factors associated with thrombosis that may contribute to recurrent pregnancy loss (habitual abortion), specifically differences in serum levels of platelet-activating factor and thrombin-activatable ...
Ayla Eser +9 more
doaj +1 more source
Modification of biological parameters after treatment with recombinant factor VIIa in a patient with thrombocytopathy due to storage pool disease [PDF]
, 2005 Patients with thrombocytopathy due to storage pool disease mostly suffer from mild bleeding diathesis. However surgical interventions can lead to excess bleeding.
Almeida +10 more
core +2 more sources