Results 141 to 150 of about 4,071,532 (408)

Inhibition by cardiolipins of platelet‐activating factor‐induced rabbit platelet activation

Lipids, 1993
AbstractEvidence is presented that cardiolipin, a naturally occurring phospholipid, inhibits the aggregatory effect of platelet‐activating factor (paf) on rabbit plateletsin vitro. Bovine heart cardiolipin was shown to inhibit the aggregation of washed rabbit platelets induced by 1×10−10 M and 2×10−10 M paf with IC50 values (doses for half‐maximal ...
Tsoukatos, D., Demopoulos, C. A., Tselepis, A. D., Moschidis, M. C., Donos, A., Evangelou, A., Benveniste, J.   +6 more
openaire   +4 more sources

Defective Platelet Activation and Bleeding Complications upon Cholestasis in Mice

Cellular Physiology and Biochemistry, 2017
Background/Aims: Platelets are essential mediators of hemostasis to avoid excessive blood loss. Cirrhosis and chronic liver diseases are characterized by alterations in hemostasis.
Nina Sarah Gowert, Meike Klier, Maria Reich, Friedrich Reusswig, Lili Donner, Verena Keitel, Dieter Häussinger, Margitta Elvers   +7 more
doaj   +1 more source

Canine platelets express functional Toll-like receptor-4: lipopolysaccharide-triggered platelet activation is dependent on adenosine diphosphate and thromboxane A2 in dogs. [PDF]

, 2019
BackgroundFunctional Toll-like receptor 4 (TLR4) has been characterized in human and murine platelets indicating that platelets play a role in inflammation and hemostasis during sepsis. It is unclear whether canine platelets could express functional TLR4
Li, Ronald HL, Nguyen, Nghi, Tablin, Fern   +2 more
core   +1 more source

Platelet G i protein Gα i2 is an essential mediator of thrombo-inflammatory organ damage in mice [PDF]

, 2015
Platelets are crucial for hemostasis and thrombosis and exacerbate tissue injury following ischemia and reperfusion. Important regulators of platelet function are G proteins controlled by seven transmembrane receptors.
Beer-Hammer, Sandra, Birnbaumer, Lutz, Cherpokova, Deya, Devanathan, Vasudharani, Hagedorn, Ina, Kraft, Peter, Köhler, David, Nieswandt, Bernhard, Nürnberg, Bernd, Pexa, Katja, Piekorz, Roland P., Rosenberger, Peter, Singh, Madhurendra, Stoll, Guido   +13 more
core   +1 more source

The Emerging 4D Printing of Shape‐Memory Thermomorphs for Self‐Adaptative Biomedical Implants

Advanced Functional Materials, EarlyView.
4D printing enables the creation of smart implants that adapt to changing conditions in the human body over time. At the core of this technology are shape‐memory thermomorphs (SMTMs). This review offers an in‐depth analysis of 4D printing with SMTMs, emphasizing the latest advancements in smart materials, stimuli, programming principles, and their ...
Aixiang Ding, Fang Tang, Eben Alsberg
wiley   +1 more source

PDK1 regulates platelet activation and arterial thrombosis.

Blood, 2013
The effects of phosphoinositide-dependent protein kinase 1 (PDK1), a master kinase in the phosphoinositide 3-kinase/Akt pathway, on platelet activation are unknown.
Xue Chen, Yue Zhang, Yanhua Wang, Ding Li, Lin Zhang, Kemin Wang, Xinping Luo, Zhongzhou Yang, Yi Wu, Junling Liu   +9 more
semanticscholar   +1 more source

Cell adhesive peptides functionalized on CoCr alloy stimulate endothelialization and prevent thrombogenesis and restenosis [PDF]

, 2017
Immobilization of bioactive peptide sequences on CoCr surfaces is an effective route to improve endothelialization, which is of great interest for cardiovascular stents. In this work, we explored the effect of physical and covalent immoblization of RGDS,
Castellanos, Maria Isabel, Díaz Ricart, Maribel, Escolar Albaladejo, Ginés, Gil Mur, Francisco Javier, Ginebra Molins, Maria Pau, Guillem Martí, Jordi, Manero Planella, José María, Mas Moruno, Carlos, Pegueroles Neyra, Marta   +8 more
core   +3 more sources

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Increased platelet reactivity and platelet–leukocyte aggregation after elective coronary bypass surgery

Platelets, 2019
Inflammatory mechanisms are activated, and thrombotic complications occur during the initial months after coronary artery bypass grafting (CABG). Therefore, changes over time of platelet activation and platelet–leukocyte interactions after CABG are of ...
Torbjörn Ivert, Magnus Dalén, Charlotte Ander, Ragnhild Stålesen, Marie Lordkipanidzé, Paul Hjemdahl   +5 more
doaj   +1 more source

Butterfly‐Inspired Hierarchical Hybrid Composites for Lightweight Structural Thermal Management Applications

Advanced Functional Materials, EarlyView.
Emulating nature's unparalleled engineering, this work introduces butterfly‐inspired hybrid composites for high‐performance transportation and defense sectors. Leveraging biomimicry, these lightweight composites feature butterfly leg‐inspired hierarchical fibrous assemblies and butterfly wing‐inspired sandwich‐structured architecture, to achieve ...
Nello D. Sansone, Rafaela Aguiar, Mahmoud Embabi, Nichole Cheung, Anthony V. Tuccitto, Nathan R. S. Chang, Matthew Leroux, Patrick C. Lee   +7 more
wiley   +1 more source