Results 11 to 20 of about 4,071,532 (408)
Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1985 Platelets are discoidal cytoplasmic particles that respond to a variety of stimuli by developing filopodia and rounding up (shape change), developing the ability to bind fibrinogen from the medium, and, with strong stimuli such as thrombin and PAF-acether, secreting the contents of several types of granules.
M B, Zucker, V T, Nachmias
openaire +3 more sources
Platelet signaling: a complex interplay between inhibitory and activatory networks [PDF]
Journal of Thrombosis and Haemostasis, 2016 The role of platelets in hemostasis and thrombosis is dependent on a complex balance of activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy vasculature suppress platelet activation in the absence of platelet ...
Jonathan M Gibbins
exaly +3 more sources
Platelets, 2022 Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of ...
Alexander Åkesson +7 more
doaj +1 more source
Baseline Platelet Activation and Reactivity in Patients with Critical Limb Ischemia. [PDF]
PLoS ONE, 2015 Patients with critical limb ischemia (CLI) have a high risk to develop cardiovascular events (CVE). We hypothesized that in CLI patients platelets would display increased baseline activation and reactivity.We investigated baseline platelet activation and
Peter Paul Wisman +5 more
doaj +1 more source
Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor [PDF]
, 2014 Introduction Idiopathic Pulmonary Fibrosis (IPF) is a progressive, incurable fibrotic interstitial lung disease with a prognosis worse than many cancers. Its pathogenesis is poorly understood.
Crooks, Michael +8 more
core +11 more sources
C1-inhibitor influence on platelet activation by thrombin receptors agonists
Clinical and Applied Thrombosis/Hemostasis, 2022 Introduction Protease activated receptors 1 (PAR1) and 4 (PAR4) agonists are used to study platelet activation. Data on platelet activation are extrapolated across experimental settings.
Ivan D. Tarandovskiy PhD +2 more
doaj +1 more source
Blood, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent pathogen responsible for the coronavirus disease 2019 (COVID-19). Since its emergence, the novel coronavirus has rapidly achieved pandemic proportions causing remarkably ...
E. D. Hottz +11 more
semanticscholar +1 more source
The Dynamics of Platelet Activation during the Progression of Streptococcal Sepsis. [PDF]
PLoS ONE, 2016 Platelets contribute to inflammation however, the role of platelet activation during the pathophysiological response to invasive bacterial infection and sepsis is not clear.
Sinead M Hurley +3 more
doaj +1 more source
Circulation, 2020 Background: Proprotein convertase subtilisin/kexin 9 (PCSK9), mainly secreted by the liver and released into the blood, elevates plasma low-density lipoprotein (LDL) cholesterol by degrading LDL receptor.
Zhiyong Qi +15 more
semanticscholar +1 more source
Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse. [PDF]
PLoS ONE, 2015 Recent work has indicated that platelets, which are anucleate blood cells, significantly contribute to inflammatory disorders. Importantly, platelets also likely contribute to various inflammatory secondary disorders that are increasingly associated with
Michelle Kiebala +5 more
doaj +1 more source