Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 2020 Platelets are discoidal cytoplasmic particles that respond to a variety of stimuli by developing filopodia and rounding up (shape change), developing the ability to bind fibrinogen from the medium, and, with strong stimuli such as thrombin and PAF ...
Marjorie B. Zucker, V. Nachmias
semanticscholar +3 more sources
Platelet Counts and Platelet Activation Markers in Obese Subjects [PDF]
Mediators of Inflammation, 2008 Objective. In this work we studied the correlation between platelet count, platelet activation, and systemic inflammation in overweight, obese, and morbidly obese individuals. Methods and subjects.
Abu-Abeid, Subchi +8 more
core +8 more sources
The Dynamics of Platelet Activation during the Progression of Streptococcal Sepsis. [PDF]
PLoS ONE, 2016 Platelets contribute to inflammation however, the role of platelet activation during the pathophysiological response to invasive bacterial infection and sepsis is not clear.
Sinead M Hurley +3 more
doaj +1 more source
Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse. [PDF]
PLoS ONE, 2015 Recent work has indicated that platelets, which are anucleate blood cells, significantly contribute to inflammatory disorders. Importantly, platelets also likely contribute to various inflammatory secondary disorders that are increasingly associated with
Michelle Kiebala +5 more
doaj +1 more source
Zinc: an endogenous and exogenous regulator of platelet function during hemostasis and thrombosis
Platelets, 2021 Zinc (Zn2+) is an essential micronutrient and the second most abundant trace metal in the human body. The important role that Zn2+ plays in hemostasis is exemplified by platelet-related bleeding phenotypes coinciding with dietary Zn2+ deficiency.
Niaz Shahed Ahmed +2 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundChancre self-healing, a typical clinical phenomenon of primary syphilis, is essentially wound healing. The first response to a wound is constriction of the injured blood vessels and activation of platelets to form a fibrin clot.
Qiu-Yan Xu +9 more
doaj +1 more source
Application of an optimized flow cytometry-based quantification of Platelet Activation (PACT): Monitoring platelet activation in platelet concentrates. [PDF]
PLoS ONE, 2017 BACKGROUND:Previous studies have shown that flow cytometry is a reliable test to quantify platelet function in stored platelet concentrates (PC). It is thought that flow cytometry is laborious and hence expensive.
Cécile H Kicken +4 more
doaj +1 more source
Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]
, 2020 Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar +45 more
core +1 more source
Platelet surface-associated activation and secretion-mediated inhibition of coagulation factor XII. [PDF]
PLoS ONE, 2015 Coagulation factor XII (fXII) is important for arterial thrombosis, but its physiological activation mechanisms are unclear. In this study, we elucidated the role of platelets and platelet-derived material in fXII activation.
Natalia V Zakharova +6 more
doaj +1 more source
TH Open, 2023 Background Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis even when they do not have antiphospholipid syndrome (APS). Interactions between complement activation and activated platelets have been suggested in SLE and
Signe Risbøl Vils +3 more
doaj +1 more source