Results 31 to 40 of about 470,674 (313)

The platelet transcriptome and proteome in Alzheimer’s disease and aging: an exploratory cross-sectional study

Frontiers in Molecular Biosciences, 2023
Introduction: Alzheimer’s disease (AD) and aging are associated with platelet hyperactivity. However, the mechanisms underlying abnormal platelet function in AD and aging are yet poorly understood.Methods: To explore the molecular profile of AD and aged ...
Diana M. Bessa de Sousa, Diana M. Bessa de Sousa, Rodolphe Poupardin, Rodolphe Poupardin, Saul A. Villeda, Adam B. Schroer, Thomas Fröhlich, Vanessa Frey, Vanessa Frey, Wolfgang Staffen, Heike Mrowetz, Heike Mrowetz, Barbara Altendorfer, Barbara Altendorfer, Michael S. Unger, Michael S. Unger, Bernhard Iglseder, Bernhard Paulweber, Eugen Trinka, Eugen Trinka, Eugen Trinka, Janne Cadamuro, Martin Drerup, Katharina Schallmoser, Katharina Schallmoser, Ludwig Aigner, Ludwig Aigner, Ludwig Aigner, Kathrin M. Kniewallner, Kathrin M. Kniewallner   +29 more
doaj   +1 more source

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3 [PDF]

, 2016
Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human ...
Arman, Mònica, Cox, Dermot, Henderson, Ian R., Kerrigan, Steven W., Watson, Callum N., Watson, Steve P.   +5 more
core   +4 more sources

Platelets and infection — an emerging role of platelets in viral infection

Frontiers in Immunology, 2014
Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis. While platelet activation and elevated platelet counts (thrombocytosis) are associated with increased risk of thrombotic complications, low platelet counts ...
Alice eAssinger, Alice eAssinger
doaj   +1 more source

PD-L1 Regulates Platelet Activation and Thrombosis via Caspase-3/GSDME Pathway

Frontiers in Pharmacology, 2022
Platelets play a central role in hemostasis and thrombosis, regulating the occurrence and development of thrombotic diseases, including ischemic stroke. Programmed death ligand 1 (PD-L1) has recently been detected in platelet, while the function of PD-L1
Yulong Li, Guang Xin, Shiyi Li, Yuman Dong, Yuda Zhu, Xiuxian Yu, Chengyu Wan, Fan Li, Zeliang Wei, Yilan Wang, Kun Zhang, Qingqiu Chen, Hai Niu, Wen Huang   +13 more
doaj   +1 more source

Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets [PDF]

, 2018
Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis.
Birnbaumer, Lutz, Bissinger, Rosi, Cao, Hang, Gawaz, Meinrad, Lang, Elisabeth, Lang, Florian, Leiss, Veronika, Nürnberg, Bernd, Pelzl, Lisann, Pieske, Burkert, Qadri, Syed M., Umbach, Anja T., Voelkl, Jakob   +12 more
core   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Berliner JA, Bittman R, Casals-Stenzal J, Esterbauer H, Fernandez-Ortiz A, Frey B, Goetzl EJ, Holvoet P, Itabe H, Kamido H, Kamido H, Kern H, Kinsella BT, Kitagawa S, O'Flaherty JT, O'Flaherty JT, Rasmussen UB, Sevanian A, Subbanagounder G, Tanaka T, Trip MD, Volf I, Watson AD, Weidtmann A   +23 more
core   +1 more source

Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis

Platelets, 2019
Platelets and Toll-like receptor (TLR) signalling play a role in the immune response during sepsis. Although preclinical knowledge about the role of platelet TLR signalling is increasing, data during human sepsis are less abundant.
Theodora A.M. Claushuis, Annelou I.P. Van Der Veen, Janneke Horn, Marcus J. Schultz, Riekelt H. Houtkooper, Cornelis Van ’T Veer, Tom Van Der Poll   +6 more
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Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production [PDF]

, 2017
The effect of lipopolysaccharide (LPS) on platelet aggregation is still controversial. We performed in vitro and ex vivo studies in controls and in patients with community-acquired pneumonia (CAP) to assess the effect of LPS on platelet activation (PA ...
Camilla Calvieri, Cristina Nocella, Daniele Pastori, Francesco Violi, Gijón, Marta Novo, Pasquale Pignatelli, Roberto Cangemi, Roberto Carnevale, Simona Bartimoccia   +9 more
core   +1 more source

Platelet activation in adult HIV-infected patients on antiretroviral therapy: a systematic review and meta-analysis

BMC Medicine, 2020
Background Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD).
Bongani B. Nkambule, Vuyolwethu Mxinwa, Zibusiso Mkandla, Tinashe Mutize, Kabelo Mokgalaboni, Tawanda M. Nyambuya, Phiwayinkosi V. Dludla   +6 more
doaj   +1 more source

Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner [PDF]

, 2015
Following platelet adhesion and primary activation at sites of vascular injury, secondary platelet activation is induced by soluble platelet agonists, such as ADP, ATP, thrombin and thromboxane.
Asselin, Ben R. Watson, Blake, Dominique Bihan, Emery, Faure, Forbes, Gibbins, Gibbins, Golden, Gordon, Gorodetsky, Heyns Adu, Jarvis, Jean-Daniel M. Malcor, Joanna-Marie Howes, Jung, Kehrel, Kirk A. Taylor, Knight, Konopatskaya, Mahdi, Marx, Marx, Milne, Morton, Nathan A. White, Nicholas Pugh, Onley, Pugh, Pugh, Raynal, Richard W. Farndale, Ruggeri, Sharir, Smethurst, Stadler, Stefanini, Stewart O. Sage, Trybulec, Vallee, Varga-Szabo, Xia, Zhang, Zufferey   +44 more
core   +1 more source