Results 11 to 20 of about 1,906,243 (299)

Lipolysis generates platelet dysfunction after in vivo heparin administration [PDF]

, 2002
Heparin, when administered to patients undergoing operations using cardiopulmonary bypass, induces plasma changes that gradually impair platelet macroaggregation, but heparinization of whole blood in vitro does not have this effect.
Day, S., Chaudhry, M.A., Muriithi, E.W., Belcher, P.R.   +3 more
core   +8 more sources

Investigations into effects of 12-lipoxygenase and NADPH oxidase on platelet activity, and influences of dietary dark chocolate [PDF]

, 2012
PhDPlatelets play a pivotal role in both normal hemostasis and pathological bleeding and importantly also contribute to the development of atherothrombosis.
Zain, Zetty Nadia Mohd
core   +4 more sources

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Siedler, F., Sellmayer, Alois, Gopfert, M. S., Siess, W.   +3 more
core   +1 more source

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2 [PDF]

, 2008
Background: The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCc2 in platelets downstream of GPVI/FcRc and the C-type lectin receptor CLEC-2.
Pearce, AC, Watson, Steve P, Watson, Steve P., Eble, JA, Pearce, Andrew C., Pearce, A C, Hughes, C E, McGlade, Jane, Eble, Johannes A., Auger, Jocelyn; id_orcid, McGlade, J, Auger, Jocelyn M., Watson, Steve; id_orcid, Eble, J A, Pearce, Andrew C, Auger, J M, Watson, S P, Hughes, Craig, Hughes, C.E, Hughes, Craig E.   +19 more
core   +2 more sources

Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway [PDF]

, 2003
Background: The regulation of platelet function by pharmacological agents that modulate platelet signaling haspharmacolo proven a successful approach to the prevention of thrombosis.
Cicmil, M, C. M. Williams, G. P. Hubbard, T. Sage, Stevens, J M; id_orcid, P. A. Jordan, J. M. Gibbins, M. Cicmil, Sage, T, Gibbins, J.M., Williams, C M, Gibbins, J M, Jordan, P A, Lovegrove, J A, Hubbard, G P, J. A. Lovegrove, J. M. Stevens, Stevens, J.M., Williams, C.M., Jordan, P.A., Lovegrove, J.A., Hubbard, G.P., Cicmil, M., Sage, T.   +23 more
core   +1 more source

Platelets and the Lectin Pathway of Complement Activation in Patients with Systemic Lupus Erythematosus or Antiphospholipid Syndrome

TH Open, 2023
Background Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis even when they do not have antiphospholipid syndrome (APS). Interactions between complement activation and activated platelets have been suggested in SLE and
Signe Risbøl Vils, Anne Troldborg, Anne-Mette Hvas, Steffen Thiel   +3 more
doaj   +1 more source

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]

, 2006
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Wolfgang Siess, Siess, Wolfgang
core   +1 more source

PD-L1 Regulates Platelet Activation and Thrombosis via Caspase-3/GSDME Pathway

Frontiers in Pharmacology, 2022
Platelets play a central role in hemostasis and thrombosis, regulating the occurrence and development of thrombotic diseases, including ischemic stroke. Programmed death ligand 1 (PD-L1) has recently been detected in platelet, while the function of PD-L1
Yulong Li, Guang Xin, Shiyi Li, Yuman Dong, Yuda Zhu, Xiuxian Yu, Chengyu Wan, Fan Li, Zeliang Wei, Yilan Wang, Kun Zhang, Qingqiu Chen, Hai Niu, Wen Huang   +13 more
doaj   +1 more source

Interleukin-6 and asymmetric dimethylarginine are associated with platelet activation after percutaneous angioplasty with stent implantation. [PDF]

PLoS ONE, 2015
Data linking in vivo platelet activation with inflammation and cardiovascular risk factors are scarce. Moreover, the interrelation between endothelial dysfunction as early marker of atherosclerosis and platelet activation has not been studied, so far. We
Thomas Gremmel, Thomas Perkmann, Christoph W Kopp, Daniela Seidinger, Beate Eichelberger, Renate Koppensteiner, Sabine Steiner, Simon Panzer   +7 more
doaj   +1 more source

Platelets and infection — an emerging role of platelets in viral infection

Frontiers in Immunology, 2014
Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis. While platelet activation and elevated platelet counts (thrombocytosis) are associated with increased risk of thrombotic complications, low platelet counts ...
Alice eAssinger, Alice eAssinger
doaj   +1 more source