Results 11 to 20 of about 287,515 (269)
Molecular Pharmacology, 2009 Platelet-activating factor (PAF) is a potent, bioactive phospholipid that acts on multiple cells and tissues through its G protein-coupled receptor (GPCR). PAF is not stored but is rapidly generated via enzymatic acetylation of the precursor 1-O-hexadecyl-2-hydroxy-sn-glycero-3-phosphocholine (lysoPAF). The bioactivity of PAF is effectively and tightly
Emily J, Welch +9 more
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Interleukin-6 and asymmetric dimethylarginine are associated with platelet activation after percutaneous angioplasty with stent implantation. [PDF]
PLoS ONE, 2015 Data linking in vivo platelet activation with inflammation and cardiovascular risk factors are scarce. Moreover, the interrelation between endothelial dysfunction as early marker of atherosclerosis and platelet activation has not been studied, so far. We
Thomas Gremmel +7 more
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Platelets and infection — an emerging role of platelets in viral infection
Frontiers in Immunology, 2014 Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis. While platelet activation and elevated platelet counts (thrombocytosis) are associated with increased risk of thrombotic complications, low platelet counts ...
Alice eAssinger, Alice eAssinger
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Frontiers in Molecular Biosciences, 2023 Introduction: Alzheimer’s disease (AD) and aging are associated with platelet hyperactivity. However, the mechanisms underlying abnormal platelet function in AD and aging are yet poorly understood.Methods: To explore the molecular profile of AD and aged ...
Diana M. Bessa de Sousa +29 more
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Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis
Platelets, 2019 Platelets and Toll-like receptor (TLR) signalling play a role in the immune response during sepsis. Although preclinical knowledge about the role of platelet TLR signalling is increasing, data during human sepsis are less abundant.
Theodora A.M. Claushuis +6 more
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BMC Medicine, 2020 Background Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD).
Bongani B. Nkambule +6 more
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PD-L1 Regulates Platelet Activation and Thrombosis via Caspase-3/GSDME Pathway
Frontiers in Pharmacology, 2022 Platelets play a central role in hemostasis and thrombosis, regulating the occurrence and development of thrombotic diseases, including ischemic stroke. Programmed death ligand 1 (PD-L1) has recently been detected in platelet, while the function of PD-L1
Yulong Li +13 more
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A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation
Haematologica, 2018 HLA antibodies are associated with refractoriness to platelet transfusion, leading to rapid platelet clearance, sometimes coinciding with clinical side effects such as fever and chills.
Maaike Rijkers +11 more
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Endogenous SIRT6 in platelets negatively regulates platelet activation and thrombosis
Frontiers in Pharmacology, 2023 Thromboembolism resulting from platelet dysfunction constitutes a significant contributor to the development of cardiovascular disease. Sirtuin 6 (SIRT6), an essential NAD+-dependent enzyme, has been linked to arterial thrombosis when absent in ...
Yanli Liu +13 more
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Platelets, 2022 We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use to analyze activated but non-complexed platelets via flow cytometry.
Martina Aguiar Bucsai +4 more
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