Results 21 to 30 of about 1,906,243 (299)

The platelet transcriptome and proteome in Alzheimer’s disease and aging: an exploratory cross-sectional study

Frontiers in Molecular Biosciences, 2023
Introduction: Alzheimer’s disease (AD) and aging are associated with platelet hyperactivity. However, the mechanisms underlying abnormal platelet function in AD and aging are yet poorly understood.Methods: To explore the molecular profile of AD and aged ...
Diana M. Bessa de Sousa, Diana M. Bessa de Sousa, Rodolphe Poupardin, Rodolphe Poupardin, Saul A. Villeda, Adam B. Schroer, Thomas Fröhlich, Vanessa Frey, Vanessa Frey, Wolfgang Staffen, Heike Mrowetz, Heike Mrowetz, Barbara Altendorfer, Barbara Altendorfer, Michael S. Unger, Michael S. Unger, Bernhard Iglseder, Bernhard Paulweber, Eugen Trinka, Eugen Trinka, Eugen Trinka, Janne Cadamuro, Martin Drerup, Katharina Schallmoser, Katharina Schallmoser, Ludwig Aigner, Ludwig Aigner, Ludwig Aigner, Kathrin M. Kniewallner, Kathrin M. Kniewallner   +29 more
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Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis

Platelets, 2019
Platelets and Toll-like receptor (TLR) signalling play a role in the immune response during sepsis. Although preclinical knowledge about the role of platelet TLR signalling is increasing, data during human sepsis are less abundant.
Theodora A.M. Claushuis, Annelou I.P. Van Der Veen, Janneke Horn, Marcus J. Schultz, Riekelt H. Houtkooper, Cornelis Van ’T Veer, Tom Van Der Poll   +6 more
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Platelet activation in adult HIV-infected patients on antiretroviral therapy: a systematic review and meta-analysis

BMC Medicine, 2020
Background Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD).
Bongani B. Nkambule, Vuyolwethu Mxinwa, Zibusiso Mkandla, Tinashe Mutize, Kabelo Mokgalaboni, Tawanda M. Nyambuya, Phiwayinkosi V. Dludla   +6 more
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Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation

Platelets, 2022
We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use to analyze activated but non-complexed platelets via flow cytometry.
Martina Aguiar Bucsai, Christian Idel, Barbara Wollenberg, Christine Mannhalter, Admar Verschoor   +4 more
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Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]

, 2002
Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E., Ney, L., Massberg, S., Goetz, Alwin Eduard, Eichhorn, M. E.;Ney, L.;Massberg, S.;Goetz, A. E.   +4 more
core   +1 more source

A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation

Haematologica, 2018
HLA antibodies are associated with refractoriness to platelet transfusion, leading to rapid platelet clearance, sometimes coinciding with clinical side effects such as fever and chills.
Maaike Rijkers, Anno Saris, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Ruben Bierings, Frank W.G. Leebeek, A.J. Gerard Jansen, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +11 more
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Endogenous SIRT6 in platelets negatively regulates platelet activation and thrombosis

Frontiers in Pharmacology, 2023
Thromboembolism resulting from platelet dysfunction constitutes a significant contributor to the development of cardiovascular disease. Sirtuin 6 (SIRT6), an essential NAD+-dependent enzyme, has been linked to arterial thrombosis when absent in ...
Yanli Liu, Tao Wang, Qilong Zhou, Guang Xin, Hai Niu, Fan Li, Yilan Wang, Shiyi Li, Yuman Dong, Kun Zhang, Lijuan Feng, Wei Fu, Boli Zhang, Wen Huang   +13 more
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The effects of signal transducer and activator of transcription three mutations on human platelets

Platelets, 2018
Involvement of signal transducer and activator of transcription 3 (STAT3) in inflammation is well known. Recently, a role for STAT3 in platelet activation and platelet production has been suggested.
Floor E. Aleva, Frank L. van de Veerdonk, Yang Li, Rahajeng N. Tunjungputri, Sami Simons, Philip G. De Groot, Mihai M. Netea, Yvonne F. Heijdra, Quirijn de Mast, André J.A.M. van der Ven   +9 more
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Impact of diabetes on platelet activation in different manifestations of atherosclerosis

Swiss Medical Weekly, 2013
BACKGROUND: Atherosclerosis affects many patients with type 2 diabetes. Both are associated with platelet activation, but it remains unclear how diabetes contributes to, or even enhances, platelet activation in patients with atherosclerosis.
Thomas Gremmel, Christoph W Kopp, Daniela Seidinger, Renate Koppensteiner, Sabine Steiner, Simon Panzer   +5 more
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Synergistic inhibitory effects of clopidogrel and rivaroxaban on platelet function and platelet‐dependent thrombin generation in cats

Journal of Veterinary Internal Medicine, 2023
Background Dual antithrombotic treatment (DAT) with clopidogrel and rivaroxaban sometimes is prescribed to cats with hypertrophic cardiomyopathy at risk of thromboembolism.
Sara T. Lo, Ronald H. L. Li, Catherine J. Georges, Nghi Nguyen, Cheyenne K. Chen, Claire Stuhlmann, Maureen Sigmund Oldach, Victor Noel Rivas, Samantha Fousse, Samantha P. Harris, Joshua A. Stern   +10 more
doaj   +1 more source