Results 201 to 210 of about 467,395 (313)

Ononin suppresses tumor-induced platelet activation and invasion and enhances cell-cycle arrest and apoptosis in triple-negative breast cancer cells. [PDF]

Sci Rep
Al-Kabariti AY, Abbas MA, Alsarayreh N, Alqudah DA, Abuarqoub D, Atieh SH, Smarakan S, Shaer WA.   +7 more
europepmc   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Metabolic Reprogramming in Toll-like Receptor-Mediated Platelet Activation. [PDF]

Cells
Cheah LT, Khalil JS, McKay M, Ali M, Duval C, Unsworth AJ, Naseem KM.   +6 more
europepmc   +1 more source

Investigation on the mechanisms of action of aprotinin in cardiac surgery [PDF]

, 1991
Baranky, A., Dietrich, W., Friedel, N., Hetzer, P., Jochum, Marianne, Richter, J. A., Royston, D., Spannagl, Michael, Wendt, P.   +8 more
core   +1 more source

Bioabsorbable Endovascular Adhesive Tape (BEAT) for Improving Vascular Regeneration

Advanced Science, EarlyView.
A bioabsorbable endovascular adhesive tape (BEAT) platform based on a hierarchical polyelectrolyte complex is developed to enhance drug delivery in the DCB system. The coating enables rapid transfer to the vessel, provides short‐term mechanical support, and promotes both immediate transfer and long‐term retention of drugs at the lesion site.
Jiarong Wang, Jing Wang, Xinyi Li, Bo Yu, Yiduo Chen, Yirong Guo, Honglin Qian, Meng Hu, Haoyang Liu, Wenhui Liu, Han Xu, Kefeng Ren, M. Cristina L. Martins, Jian Ji   +13 more
wiley   +1 more source

Direct Binding of Lyn to GPIbβ Transmits 2-Way GPIb-IX Signaling to Stimulate Platelet Activation and VWF Binding. [PDF]

Circ Res
Zhang Y, Liang Y, Kazemipour Ashkezari AH, Wang C, Chang CW, Bai Y, Huang X, Mack A, Yang H, Cong P, Cheng N, Zhu C, Du X.   +12 more
europepmc   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

The Effects of Inclisiran on the Subclinical Prothrombotic and Platelet Activation Markers in Patients at High Cardiovascular Risk. [PDF]

J Cardiovasc Dev Dis
Maligłówka M, Dec A, Bułdak Ł, Okopień B.   +3 more
europepmc   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Is GPIbα really a master regulator of platelet activation? [PDF]

Blood Adv
Watson BE, Salles-Crawley II.
europepmc   +1 more source