Interleukin-6 and asymmetric dimethylarginine are associated with platelet activation after percutaneous angioplasty with stent implantation. [PDF]
PLoS ONE, 2015 Data linking in vivo platelet activation with inflammation and cardiovascular risk factors are scarce. Moreover, the interrelation between endothelial dysfunction as early marker of atherosclerosis and platelet activation has not been studied, so far. We
Thomas Gremmel +7 more
doaj +1 more source
Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets [PDF]
, 2018 Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis.
Birnbaumer, Lutz +12 more
core +1 more source
PD-L1 Regulates Platelet Activation and Thrombosis via Caspase-3/GSDME Pathway
Frontiers in Pharmacology, 2022 Platelets play a central role in hemostasis and thrombosis, regulating the occurrence and development of thrombotic diseases, including ischemic stroke. Programmed death ligand 1 (PD-L1) has recently been detected in platelet, while the function of PD-L1
Yulong Li +13 more
doaj +1 more source
Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis
Platelets, 2019 Platelets and Toll-like receptor (TLR) signalling play a role in the immune response during sepsis. Although preclinical knowledge about the role of platelet TLR signalling is increasing, data during human sepsis are less abundant.
Theodora A.M. Claushuis +6 more
doaj +1 more source
BMC Medicine, 2020 Background Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD).
Bongani B. Nkambule +6 more
doaj +1 more source
Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]
, 2018 The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Bye, Alex P. +6 more
core +4 more sources
A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation
Haematologica, 2018 HLA antibodies are associated with refractoriness to platelet transfusion, leading to rapid platelet clearance, sometimes coinciding with clinical side effects such as fever and chills.
Maaike Rijkers +11 more
doaj +1 more source
Journal of Veterinary Internal Medicine, 2023 Background Dual antithrombotic treatment (DAT) with clopidogrel and rivaroxaban sometimes is prescribed to cats with hypertrophic cardiomyopathy at risk of thromboembolism.
Sara T. Lo +10 more
doaj +1 more source
Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production [PDF]
, 2017 The effect of lipopolysaccharide (LPS) on platelet aggregation is still controversial. We performed in vitro and ex vivo studies in controls and in patients with community-acquired pneumonia (CAP) to assess the effect of LPS on platelet activation (PA ...
Camilla Calvieri +9 more
core +1 more source
Acetylcholine Inhibits Platelet Activation [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2019 Platelets are key mediators of thrombosis. Many agonists of platelet activation are known, but fewer endogenous inhibitors of platelets, such as prostacyclin and nitric oxide (NO), have been identified. Acetylcholinesterase inhibitors, such as donepezil, can cause bleeding in patients, but the underlying mechanisms are not well understood.
John A, Bennett +8 more
openaire +2 more sources