Genetic determinants of on-aspirin platelet reactivity: focus on the influence of PEAR1. [PDF]
PLoS ONE, 2014 Platelet aggregation during aspirin treatment displays considerable inter-individual variability. A genetic etiology likely exists, but it remains unclear to what extent genetic polymorphisms determine platelet aggregation in aspirin-treated individuals ...
Morten Würtz +4 more
doaj +1 more source
Post-Synthetic Treatment of Nickel-Iron Layered Double Hydroxides for the Optimum Catalysis of the Oxygen Evolution Reaction [PDF]
npj 2D Mater Appl 5, 73 (2021), 2022 Nickel-iron layered double hydroxide (NiFe LDH) platelets with high morphological regularity and sub-micrometre lateral dimensions were synthesized using a homogeneous precipitation technique for highly efficient catalysis of the oxygen evolution reaction (OER).
arxiv +1 more source
HIV-1 induces in vivo platelet activation by enhancing platelet NOX2 activity. [PDF]
, 2015 OBJECTIVES: HIV-1 patients show increased platelet activation, but the mechanisms involved are not completely clarified. We speculated that HIV-1 might induce in vivo platelet activation by enhancing platelet NOX2-related oxidative stress.
Bartimoccia, Simona +9 more
core +1 more source
Frontiers in Molecular Biosciences, 2023 Introduction: Alzheimer’s disease (AD) and aging are associated with platelet hyperactivity. However, the mechanisms underlying abnormal platelet function in AD and aging are yet poorly understood.Methods: To explore the molecular profile of AD and aged ...
Diana M. Bessa de Sousa +29 more
doaj +1 more source
Preeclampsia and platelets activation
Platelets, 2019 Dear Sir,We found the metanalysis by Jakobsen et al. regarding the function of platelets in preeclampsia (PE) very interesting [1].
Antonio Ponzetto, Giovanna Turvani
openaire +5 more sources
Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3 [PDF]
, 2016 Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human ...
Arman, Mònica +5 more
core +3 more sources
New Concepts and Mechanisms of Platelet Activation Signaling.
Physiology, 2017 Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall and soluble agonists, which initiate platelet activation, leading to formation of hemostatic thrombi.
Brian Estevez, Xiaoping Du
semanticscholar +1 more source
Interleukin-6 and asymmetric dimethylarginine are associated with platelet activation after percutaneous angioplasty with stent implantation. [PDF]
PLoS ONE, 2015 Data linking in vivo platelet activation with inflammation and cardiovascular risk factors are scarce. Moreover, the interrelation between endothelial dysfunction as early marker of atherosclerosis and platelet activation has not been studied, so far. We
Thomas Gremmel +7 more
doaj +1 more source
Mechanobiology of shear-induced platelet aggregation leading to occlusive arterial thrombosis: a multiscale in silico analysis [PDF]
, 2021 Occlusive thrombosis in arteries causes heart attacks and strokes. The rapid growth of thrombus at elevated shear rates (~10,000 1/s) relies on shear-induced platelet aggregation (SIPA) thought to come about from the entanglement of von Willebrand factor (VWF) molecules.
arxiv +1 more source
Platelet Activation: The Mechanisms and Potential Biomarkers
BioMed Research International, 2016 Beyond hemostasis and thrombosis, an increasing number of studies indicate that platelets play an integral role in intercellular communication, mediating inflammatory and immunomodulatory activities.
Seong-Hoon Yun +4 more
semanticscholar +1 more source