Results 21 to 30 of about 4,071,532 (408)

Zinc: an endogenous and exogenous regulator of platelet function during hemostasis and thrombosis

Platelets, 2021
Zinc (Zn2+) is an essential micronutrient and the second most abundant trace metal in the human body. The important role that Zn2+ plays in hemostasis is exemplified by platelet-related bleeding phenotypes coinciding with dietary Zn2+ deficiency.
Niaz Shahed Ahmed, MariaElisa Lopes-Pires, Nicholas Pugh   +2 more
doaj   +1 more source

The Outer Membrane Lipoprotein Tp0136 Stimulates Human Platelet Activation and Aggregation Through PAR1 to Enhance Gq/Gi Signaling

Frontiers in Immunology, 2022
BackgroundChancre self-healing, a typical clinical phenomenon of primary syphilis, is essentially wound healing. The first response to a wound is constriction of the injured blood vessels and activation of platelets to form a fibrin clot.
Qiu-Yan Xu, Qiu-Yan Xu, Yong-Jing Wang, Yong-Jing Wang, Li-Rong Lin, Li-Rong Lin, Li-Li Liu, Li-Li Liu, Tian-Ci Yang, Tian-Ci Yang   +9 more
doaj   +1 more source

Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]

, 2020
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar, Banno, Bekendam, Bi, Chagas, Chagas, Chang, Chen, Chung, Dang, De Bona, Dutta-Roy, Essex, Essex, Essex, Ghoshal, Giamogante, Giamogante, Holbrook, Inoue, Jarvis, Jasuja, Jayakumar, Jordan, Kang, Kehrel, Kim, Lahav, Lakowicz, Lescano, Lin, Lu, Mangin, Masuda, Navarro-Nuñez, Park, Raffaelli, Raturi, Sharma, Sousa, Stopa, Taylor, Trnkova, Wang, Ware, Wendelboe   +45 more
core   +1 more source

Application of an optimized flow cytometry-based quantification of Platelet Activation (PACT): Monitoring platelet activation in platelet concentrates. [PDF]

PLoS ONE, 2017
BACKGROUND:Previous studies have shown that flow cytometry is a reliable test to quantify platelet function in stored platelet concentrates (PC). It is thought that flow cytometry is laborious and hence expensive.
Cécile H Kicken, Mark Roest, Yvonne M C Henskens, Bas de Laat, Dana Huskens   +4 more
doaj   +1 more source

Platelet surface-associated activation and secretion-mediated inhibition of coagulation factor XII. [PDF]

PLoS ONE, 2015
Coagulation factor XII (fXII) is important for arterial thrombosis, but its physiological activation mechanisms are unclear. In this study, we elucidated the role of platelets and platelet-derived material in fXII activation.
Natalia V Zakharova, Elena O Artemenko, Nadezhda A Podoplelova, Anastasia N Sveshnikova, Irina A Demina, Fazly I Ataullakhanov, Mikhail A Panteleev   +6 more
doaj   +1 more source

Platelets and the Lectin Pathway of Complement Activation in Patients with Systemic Lupus Erythematosus or Antiphospholipid Syndrome

TH Open, 2023
Background Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis even when they do not have antiphospholipid syndrome (APS). Interactions between complement activation and activated platelets have been suggested in SLE and
Signe Risbøl Vils, Anne Troldborg, Anne-Mette Hvas, Steffen Thiel   +3 more
doaj   +1 more source

Genetic determinants of on-aspirin platelet reactivity: focus on the influence of PEAR1. [PDF]

PLoS ONE, 2014
Platelet aggregation during aspirin treatment displays considerable inter-individual variability. A genetic etiology likely exists, but it remains unclear to what extent genetic polymorphisms determine platelet aggregation in aspirin-treated individuals ...
Morten Würtz, Peter H Nissen, Erik Lerkevang Grove, Steen Dalby Kristensen, Anne-Mette Hvas   +4 more
doaj   +1 more source

HIV-1 induces in vivo platelet activation by enhancing platelet NOX2 activity. [PDF]

, 2015
OBJECTIVES: HIV-1 patients show increased platelet activation, but the mechanisms involved are not completely clarified. We speculated that HIV-1 might induce in vivo platelet activation by enhancing platelet NOX2-related oxidative stress.
Bartimoccia, Simona, Carnevale, Roberto, Di Campli, Francesco, Esposito, Antonella, Fantauzzi, Alessandra, Mezzaroma, Ivano, Novo, Marta, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +9 more
core   +1 more source

Preeclampsia and platelets activation

Platelets, 2019
Dear Sir,We found the metanalysis by Jakobsen et al. regarding the function of platelets in preeclampsia (PE) very interesting [1].
Antonio Ponzetto, Giovanna Turvani
openaire   +5 more sources

Platelets and galectins [PDF]

, 2014
A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug.
Schattner, Mirta Ana
core   +1 more source