Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics [PDF]
, 2017 Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial cells (ECs), thrombin dynamically regulates
Hoogendijk, Arie J. +7 more
core +13 more sources
Platelet Activation: The Mechanisms and Potential Biomarkers
BioMed Research International, 2016 Beyond hemostasis and thrombosis, an increasing number of studies indicate that platelets play an integral role in intercellular communication, mediating inflammatory and immunomodulatory activities.
Seong-Hoon Yun +4 more
semanticscholar +1 more source
PD-L1 Regulates Platelet Activation and Thrombosis via Caspase-3/GSDME Pathway
Frontiers in Pharmacology, 2022 Platelets play a central role in hemostasis and thrombosis, regulating the occurrence and development of thrombotic diseases, including ischemic stroke. Programmed death ligand 1 (PD-L1) has recently been detected in platelet, while the function of PD-L1
Yulong Li +13 more
doaj +1 more source
Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets [PDF]
, 2018 Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis.
Birnbaumer, Lutz +12 more
core +1 more source
Flow-induced platelet activation in components of the extracorporeal membrane oxygenation circuit
Scientific Reports, 2018 Extracorporeal membrane oxygenation (ECMO) is used for rescue in severe respiratory and/or circulatory failure. The patient’s blood is pumped over artificial surfaces in the ECMO circuit.
G. Fuchs +3 more
semanticscholar +1 more source
Platelets and infection — an emerging role of platelets in viral infection
Frontiers in Immunology, 2014 Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis. While platelet activation and elevated platelet counts (thrombocytosis) are associated with increased risk of thrombotic complications, low platelet counts ...
Alice eAssinger, Alice eAssinger
doaj +1 more source
Interleukin-6 and asymmetric dimethylarginine are associated with platelet activation after percutaneous angioplasty with stent implantation. [PDF]
PLoS ONE, 2015 Data linking in vivo platelet activation with inflammation and cardiovascular risk factors are scarce. Moreover, the interrelation between endothelial dysfunction as early marker of atherosclerosis and platelet activation has not been studied, so far. We
Thomas Gremmel +7 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Introduction: Alzheimer’s disease (AD) and aging are associated with platelet hyperactivity. However, the mechanisms underlying abnormal platelet function in AD and aging are yet poorly understood.Methods: To explore the molecular profile of AD and aged ...
Diana M. Bessa de Sousa +29 more
doaj +1 more source
Platelet activation determines the severity of thrombocytopenia in dengue infection
Scientific Reports, 2017 Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we described a direct correlation between activation and depletion of platelets in ...
Amrita Ojha +11 more
semanticscholar +1 more source
Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis
Platelets, 2019 Platelets and Toll-like receptor (TLR) signalling play a role in the immune response during sepsis. Although preclinical knowledge about the role of platelet TLR signalling is increasing, data during human sepsis are less abundant.
Theodora A.M. Claushuis +6 more
doaj +1 more source