Results 311 to 320 of about 478,140 (363)
Some of the next articles are maybe not open access.
Activated platelets and atherosclerosis
Expert Review of Cardiovascular Therapy, 2010Several studies suggest an important role for platelets in atherogenesis, not only as mediators of thrombus formation, but also as inducers of inflammation. Several lines of evidence indicate that platelets are potent inflammatory cells that induce inflammatory responses in adjacent cells such as leukocytes and endothelial cells.
Thor Ueland +7 more
openaire +3 more sources
Blood, 2009
To the editor: Protein kinase C (PKC) is a central regulator of platelet activation, and individual PKC isoforms are likely to have distinct roles.[1][1] We and others had previously reported roles for the novel PKC isoform, PKCθ, in integrin signaling[2][2] and platelet function.[3][3] The ...
Matthew T. Harper, Alastair W. Poole
openaire +3 more sources
To the editor: Protein kinase C (PKC) is a central regulator of platelet activation, and individual PKC isoforms are likely to have distinct roles.[1][1] We and others had previously reported roles for the novel PKC isoform, PKCθ, in integrin signaling[2][2] and platelet function.[3][3] The ...
Matthew T. Harper, Alastair W. Poole
openaire +3 more sources
Platelets and Plasminogen Activation
Thrombosis and Haemostasis, 1995Platelets serve as a site for assembly of the proteins of the plasminogen activator system. Once bound to the platelet surface, tissue-type plasminogen activator manifests enhanced catalytic activity. Plasmin, once formed, also binds to the platelets surface and, at low concentrations, renders the platelet dysfunctional by cleaving glycoprotein IIIa ...
Joseph Loscalzo +3 more
openaire +3 more sources
Headache: The Journal of Head and Face Pain, 1982
SYNOPSISMigraine is a disease associated with increased platelet activity.The aim of this paper was to study "in vivo" platelet activation by assessing platelet serotonin (5HT) content and beta‐thromboglobulin (B‐TG) and platelet factor four (PF4) plasma levels, in headache‐free‐periods and during migraine attacks.In headache‐free‐periods, there was no
Francesco Ferro Milone +3 more
openaire +3 more sources
SYNOPSISMigraine is a disease associated with increased platelet activity.The aim of this paper was to study "in vivo" platelet activation by assessing platelet serotonin (5HT) content and beta‐thromboglobulin (B‐TG) and platelet factor four (PF4) plasma levels, in headache‐free‐periods and during migraine attacks.In headache‐free‐periods, there was no
Francesco Ferro Milone +3 more
openaire +3 more sources
Stress and Platelet Activation
Acta Haematologica, 1983Severe stress, with increased secretion of adrenaline, is likely to cause platelet activation. The aim of the present study was to investigate if moderate stress, which usually is not accompanied by adrenaline secretion, could induce activation of platelets, as measured by changes in the plasma concentrations of platelet factor 4 (PF-4).
Lennart Hansson +3 more
openaire +3 more sources
Platelet activation by heparin
Blood, 2011In this issue of Blood , Gao et al provide important insights into the proactivating effects of negatively charged anticoagulants on platelets.[1][1] They show outside-in signaling via the glycoprotein (GP) IIb-IIIa complex (integrin αIIbβ3) induced by heparin, low molecular weight heparin ...
openaire +3 more sources
2007
Platelet-activating factor (PAF) is a potent mediator that occurs at very low concentrations in cells and tissues. Accurate quantitation of PAF has always been difficult because of the physicochemical properties of PAF and its structural similarity to several much more abundant phospholipids.
Robert L. Wykle +2 more
openaire +3 more sources
Platelet-activating factor (PAF) is a potent mediator that occurs at very low concentrations in cells and tissues. Accurate quantitation of PAF has always been difficult because of the physicochemical properties of PAF and its structural similarity to several much more abundant phospholipids.
Robert L. Wykle +2 more
openaire +3 more sources
Platelet antithrombin activity
Thrombosis Research, 1980Abstract Platelets were studied for the presence of antithrombin (thrombin amidolytic inhibitory) activity. Platelet rich plasma contained more antithrombin activity than platelet poor plasma. This activity could be washed from a platelet pellet. Antithrombin activity increased on sonication of platelets but not following aggregation.
Emily E. Czapek, Hau C. Kwaan
openaire +3 more sources
Platelet Activating Factor and Platelets
1999Among agents which activate platelets PAF is unique since it is the only phospholipid known to date which stimulates platelets at nanomolar range. The first indications of such a mediator dates back to 1966 when it was observed that a mixture of rabbit platelets and stimulated leukocytes released histamine on specific antigen challenge (Barbaro and ...
openaire +2 more sources
Platelet Factor 3 Activity in Washed Platelets [PDF]
Thrombosis and Haemostasis, 1973 SummaryPlatelets collected with an EDTA solution and simply washed in an incomplete Tyrode’s presented clotting times in the recalcification (man and rat) and the Stypven (rat) tests that were practically identical to those of the PRP when slow speed centrifugation was used (800 G in man, 1000 G in rat). This was demonstrated, in 6 pools of 5 rats each
S Renaud, P. Gautheron, H Rosenstein
openaire +2 more sources