Results 31 to 40 of about 4,112,530 (307)

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis [PDF]

, 2009
Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke.
Abtahian, Alexandra Mazharian, Arias-Salgado, Arias-Salgado, Arthur Weiss, Asselin, Auger, Avecilla, Baker, Best, Best, Cheli, Choudhuri, Dhanjal, Dorahy, Dubois, Ezumi, Gibbins, Gibbins, Harper, Hermiston, Holsinger, Jenson Lim, Jing W. Zhu, Jocelyn M. Auger, Kalia, Kato, Klages, Kovalenko, Kralisz, Kristin N. Kornerup, Le Pera, Lin, Lin, Liu, Mangin, McCarty, McNeill, Michael G. Tomlinson, Minuz, Moarefi, Mocsai, Morton, Neena Kalia, Nonne, Obergfell, Palka, Park, Pasquet, Pasquet, Pasquet, Pearce, Poole, Quek, Senis, Snell, Somani, Sorby, Steve G. Thomas, Steve P. Watson, Stuart Ellison, Superti-Furga, Suzuki-Inoue, Suzuki-Inoue, Tarvinder Dhanjal, Tsuboi, Vandendries, Wagner, Watanabe, Watson, Wonerow, Woodside, Xu, Xu, Yamaguchi, Yan Zhao, Yotis A. Senis, Young, Zhang, Zhu   +79 more
core   +2 more sources

Platelet activation in adult HIV-infected patients on antiretroviral therapy: a systematic review and meta-analysis

BMC Medicine, 2020
Background Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD).
Bongani B. Nkambule, Vuyolwethu Mxinwa, Zibusiso Mkandla, Tinashe Mutize, Kabelo Mokgalaboni, Tawanda M. Nyambuya, Phiwayinkosi V. Dludla   +6 more
doaj   +1 more source

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]

, 2018
The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Bye, Alex P., Donaghy, Dillon, Gibbins, Jonathan M., Kriek, Neline, Osborne, Ashley A., Sage, Tanya, Unsworth, Amanda J.   +6 more
core   +4 more sources

Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue

PLoS Pathogens, 2017
Dengue is the most prevalent human arbovirus disease worldwide. Dengue virus (DENV) infection causes syndromes varying from self-limiting febrile illness to severe dengue.
M. Trugilho, E. D. Hottz, G. V. Brunoro, A. Teixeira-Ferreira, P. Carvalho, Gustavo A. Salazar, G. Zimmerman, F. Bozza, P. Bozza, J. Perales   +9 more
semanticscholar   +1 more source

A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation

Haematologica, 2018
HLA antibodies are associated with refractoriness to platelet transfusion, leading to rapid platelet clearance, sometimes coinciding with clinical side effects such as fever and chills.
Maaike Rijkers, Anno Saris, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Ruben Bierings, Frank W.G. Leebeek, A.J. Gerard Jansen, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +11 more
doaj   +1 more source

Synergistic inhibitory effects of clopidogrel and rivaroxaban on platelet function and platelet‐dependent thrombin generation in cats

Journal of Veterinary Internal Medicine, 2023
Background Dual antithrombotic treatment (DAT) with clopidogrel and rivaroxaban sometimes is prescribed to cats with hypertrophic cardiomyopathy at risk of thromboembolism.
Sara T. Lo, Ronald H. L. Li, Catherine J. Georges, Nghi Nguyen, Cheyenne K. Chen, Claire Stuhlmann, Maureen Sigmund Oldach, Victor Noel Rivas, Samantha Fousse, Samantha P. Harris, Joshua A. Stern   +10 more
doaj   +1 more source

Functional redundancy between RAP1 isoforms in murine platelet production and function [PDF]

, 2018
RAP GTPases, important regulators of cellular adhesion, are abundant signaling molecules in the platelet/megakaryocytic lineage. However, mice lacking the predominant isoform, RAP1B, display a partial platelet integrin activation defect and have a ...
Becker, Bergmeier, Bermejo, Bertozzi, Bertozzi, Bokoch, Bos, Boudreaux, Boulaftali, Boulaftali, Bouschet, Burkhart, Canault, Cattaneo, Christopher I. Jones, Chrzanowska-Wodnicka, Chrzanowska-Wodnicka, Crittenden, Dan O. Kechele, David S. Paul, Deppermann, Dorsaf Ghalloussi, Durrant, Ellen C. O'Shaughnessy, Eto, Garcia, Getz, Gloerich, Goerge, Gros, Han, Ho-Tin-Noé, Jonathan M. Gibbins, Kamata, Kamata, Kasirer-Friede, Kathleen M. Caron, Kathryn O. Poe, Kato, Klapproth, Klaus M. Hahn, Lee, Lee, Lenter, Li, Li, Lin, Lozano, Lucia Stefanini, Mazharian, Molina-Ortiz, Moore, Moser, Nieswandt, Nieswandt, Nonaka, Pan, Petrich, Piatt, Pleines, Qu, Raaijmakers, Raymond Piatt, Robert H. Lee, Rowley, Shattil, Simon, Stalker, Stefanini, Stefanini, Stefanini, Stefanini, Stefanini, Stolla, Stork, Stritt, Su, Suzuki-Inoue, Séverin, Taira, Tiedt, Wang, Watanabe, Watkins, Westbury, Wittchen, Wolfgang Bergmeier, Yacine Boulaftali, Yue, Zeiler, Zhang, Zhu   +91 more
core   +1 more source

Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release

Scientific Reports, 2016
Thrombosis and its complications are the leading cause of death in patients with diabetes. Metformin, a first-line therapy for type 2 diabetes, is the only drug demonstrated to reduce cardiovascular complications in diabetic patients.
Guang Xin, Zeliang Wei, Chengjie Ji, Huajie Zheng, Jun Gu, Limei Ma, Wenfang Huang, S. Morris-Natschke, J. Yeh, Rui Zhang, Chaoyi Qin, L. Wen, Zhihua Xing, Yu Cao, Q. Xia, Yanrong Lu, Ke Li, H. Niu, K. Lee, Wenfang Huang   +19 more
semanticscholar   +1 more source

Impact of diabetes on platelet activation in different manifestations of atherosclerosis

Swiss Medical Weekly, 2013
BACKGROUND: Atherosclerosis affects many patients with type 2 diabetes. Both are associated with platelet activation, but it remains unclear how diabetes contributes to, or even enhances, platelet activation in patients with atherosclerosis.
Thomas Gremmel, Christoph W Kopp, Daniela Seidinger, Renate Koppensteiner, Sabine Steiner, Simon Panzer   +5 more
doaj   +1 more source

Endogenous SIRT6 in platelets negatively regulates platelet activation and thrombosis

Frontiers in Pharmacology, 2023
Thromboembolism resulting from platelet dysfunction constitutes a significant contributor to the development of cardiovascular disease. Sirtuin 6 (SIRT6), an essential NAD+-dependent enzyme, has been linked to arterial thrombosis when absent in ...
Yanli Liu, Tao Wang, Qilong Zhou, Guang Xin, Hai Niu, Fan Li, Yilan Wang, Shiyi Li, Yuman Dong, Kun Zhang, Lijuan Feng, Wei Fu, Boli Zhang, Wen Huang   +13 more
doaj   +1 more source