Results 31 to 40 of about 491,468 (315)

The effects of signal transducer and activator of transcription three mutations on human platelets

Platelets, 2018
Involvement of signal transducer and activator of transcription 3 (STAT3) in inflammation is well known. Recently, a role for STAT3 in platelet activation and platelet production has been suggested.
Floor E. Aleva, Frank L. van de Veerdonk, Yang Li, Rahajeng N. Tunjungputri, Sami Simons, Philip G. De Groot, Mihai M. Netea, Yvonne F. Heijdra, Quirijn de Mast, André J.A.M. van der Ven   +9 more
doaj   +1 more source

Impact of diabetes on platelet activation in different manifestations of atherosclerosis

Swiss Medical Weekly, 2013
BACKGROUND: Atherosclerosis affects many patients with type 2 diabetes. Both are associated with platelet activation, but it remains unclear how diabetes contributes to, or even enhances, platelet activation in patients with atherosclerosis.
Thomas Gremmel, Christoph W Kopp, Daniela Seidinger, Renate Koppensteiner, Sabine Steiner, Simon Panzer   +5 more
doaj   +1 more source

Vibro-Acoustic Platelet Activation: An Additive Mechanism of Prothrombosis with Applicability to Snoring and Obstructive Sleep Apnea

Bioengineering, 2023
Introduction: Obstructive sleep apnea (OSA) and loud snoring are conditions with increased cardiovascular risk and notably an association with stroke.
Daniel E. Palomares, Phat L. Tran, Catherine Jerman, Moe Momayez, Pierre Deymier, Jawaad Sheriff, Danny Bluestein, Sairam Parthasarathy, Marvin J. Slepian   +8 more
doaj   +1 more source

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation [PDF]

, 2016
A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of ...
Bem, Danai, Finney, Brenda, Machesky, Laura M., Poulter, Natalie S., Thomas, Steven G., Watson, Stephen P.   +5 more
core   +4 more sources

Underlying mechanism and specific prevention of hemolysis-induced platelet activation

Platelets, 2017
Thromboembolic complications significantly impair the outcome of hemolytic disorders. We hypothesized that red cell adenosine diphosphate (ADP) release results in significant platelet activation in hemolysis and that this prothrombotic state can be ...
Thomas Gremmel, Simone Fedrizzi, Günter Weigel, Beate Eichelberger, Simon Panzer   +4 more
doaj   +1 more source

Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets [PDF]

, 2003
Although tissue factor (TF), the principial initiator of physiological coagulation and pathological thrombosis, has recently been proposed to be present in human blood, the functional significance and location of the intravascular TF is unknown.
Alex, Meike, Engelmann, Bernd, Klocke, Antje, Kotzsch, Matthias, Luther, Thomas, Morgenstern, Eberhard, Müller, Ingrid, Preissner, Klaus, Zahler, Stefan, Zieseniss, Susanne   +9 more
core   +1 more source

Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation

Platelets, 2022
We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use to analyze activated but non-complexed platelets via flow cytometry.
Martina Aguiar Bucsai, Christian Idel, Barbara Wollenberg, Christine Mannhalter, Admar Verschoor   +4 more
doaj   +1 more source

Functional redundancy between RAP1 isoforms in murine platelet production and function [PDF]

, 2018
RAP GTPases, important regulators of cellular adhesion, are abundant signaling molecules in the platelet/megakaryocytic lineage. However, mice lacking the predominant isoform, RAP1B, display a partial platelet integrin activation defect and have a ...
Becker, Bergmeier, Bermejo, Bertozzi, Bertozzi, Bokoch, Bos, Boudreaux, Boulaftali, Boulaftali, Bouschet, Burkhart, Canault, Cattaneo, Christopher I. Jones, Chrzanowska-Wodnicka, Chrzanowska-Wodnicka, Crittenden, Dan O. Kechele, David S. Paul, Deppermann, Dorsaf Ghalloussi, Durrant, Ellen C. O'Shaughnessy, Eto, Garcia, Getz, Gloerich, Goerge, Gros, Han, Ho-Tin-Noé, Jonathan M. Gibbins, Kamata, Kamata, Kasirer-Friede, Kathleen M. Caron, Kathryn O. Poe, Kato, Klapproth, Klaus M. Hahn, Lee, Lee, Lenter, Li, Li, Lin, Lozano, Lucia Stefanini, Mazharian, Molina-Ortiz, Moore, Moser, Nieswandt, Nieswandt, Nonaka, Pan, Petrich, Piatt, Pleines, Qu, Raaijmakers, Raymond Piatt, Robert H. Lee, Rowley, Shattil, Simon, Stalker, Stefanini, Stefanini, Stefanini, Stefanini, Stefanini, Stolla, Stork, Stritt, Su, Suzuki-Inoue, Séverin, Taira, Tiedt, Wang, Watanabe, Watkins, Westbury, Wittchen, Wolfgang Bergmeier, Yacine Boulaftali, Yue, Zeiler, Zhang, Zhu   +91 more
core   +1 more source

Effect of phosphodiesterase inhibitors on platelet function

Biochemistry and Biophysics Reports
Phosphodiesterase enzymes (PDEs) play a pivotal role in regulating platelet activity by modulating intracellular levels of cAMP and cGMP. Modulation of PDE-2, -3 and -5 activity by suitable inhibitors has been found to reduce platelet activity, and thus ...
Ravi Hochuli, Valerie Dicenta, Zoi Laspa, Manuel Sigle, Tobias Harm, Tatsiana Castor, Anne-Katrin Rohlfing, Meinrad Paul Gawaz   +7 more
doaj   +1 more source

Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets

Haematologica, 2019
High titers of HLA antibodies are associated with platelet refractoriness, causing poor platelet increments after transfusions in a subset of patients with HLA antibodies.
Maaike Rijkers, David Schmidt, Nina Lu, Cynthia S.M. Kramer, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Frank W.G. Leebeek, A.J. Gerard Jansen, Ilse Jongerius, Sacha S. Zeerleder, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +14 more
doaj   +1 more source