Results 41 to 50 of about 4,119,343 (427)

ROS in platelet biology: Functional aspects and methodological insights [PDF]

, 2020
© 2020 by the authors. Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet functions. Platelet activation determines a drastic change in redox balance and in platelet metabolism.
Carubbi, C., Galli, D., Gobbi, G., Masselli, E., Mirandola, P., Pozzi, G., Vaccarezza, Mauro, Vitale, M.   +7 more
core   +3 more sources

Platelet activation determines the severity of thrombocytopenia in dengue infection

Scientific Reports, 2017
Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we described a direct correlation between activation and depletion of platelets in ...
Amrita Ojha, Dipika Nandi, Harish Batra, Rashi Singhal, Gowtham K. Annarapu, S. Bhattacharyya, T. Seth, L. Dar, G. Medigeshi, S. Vrati, Naval K. Vikram, P. Guchhait   +11 more
semanticscholar   +1 more source

Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis

Platelets, 2019
Platelets and Toll-like receptor (TLR) signalling play a role in the immune response during sepsis. Although preclinical knowledge about the role of platelet TLR signalling is increasing, data during human sepsis are less abundant.
Theodora A.M. Claushuis, Annelou I.P. Van Der Veen, Janneke Horn, Marcus J. Schultz, Riekelt H. Houtkooper, Cornelis Van ’T Veer, Tom Van Der Poll   +6 more
doaj   +1 more source

Synergistic inhibitory effects of clopidogrel and rivaroxaban on platelet function and platelet‐dependent thrombin generation in cats

Journal of Veterinary Internal Medicine, 2023
Background Dual antithrombotic treatment (DAT) with clopidogrel and rivaroxaban sometimes is prescribed to cats with hypertrophic cardiomyopathy at risk of thromboembolism.
Sara T. Lo, Ronald H. L. Li, Catherine J. Georges, Nghi Nguyen, Cheyenne K. Chen, Claire Stuhlmann, Maureen Sigmund Oldach, Victor Noel Rivas, Samantha Fousse, Samantha P. Harris, Joshua A. Stern   +10 more
doaj   +1 more source

Low‐grade endotoxemia and platelet activation in cirrhosis

Hepatology, 2017
Patients with cirrhosis may display impaired or enhanced platelet activation, but the reasons for these equivocal findings are unclear. We investigated if bacterial lipopolysaccharide (LPS) is implicated in platelet activation. In a cross‐sectional study,
V. Raparelli, S. Basili, R. Carnevale, L. Napoleone, M. del Ben, C. Nocella, S. Bartimoccia, C. Lucidi, G. Talerico, O. Riggio, F. Violi   +10 more
semanticscholar   +1 more source

Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner [PDF]

, 2023
Hematopoietic stem cells (HSCs) residing in specialized niches in the bone marrow are responsible for the balanced output of multiple short-lived blood cell lineages in steady-state and in response to different challenges. However, feedback mechanisms by
Giustacchini, Alice
core   +7 more sources

Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity [PDF]

, 2020
Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4-CXCL4) and polyanions (P) opsonize PF4-coated bacteria hereby mediating bacterial host defense. A subset of these antibodies may activate platelets after binding to PF4-heparin complexes, causing the prothrombotic adverse drug reaction heparin-induced thrombocytopenia (HIT).
arxiv   +1 more source

Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets [PDF]

, 2018
Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis.
Birnbaumer, Lutz, Bissinger, Rosi, Cao, Hang, Gawaz, Meinrad, Lang, Elisabeth, Lang, Florian, Leiss, Veronika, Nürnberg, Bernd, Pelzl, Lisann, Pieske, Burkert, Qadri, Syed M., Umbach, Anja T., Voelkl, Jakob   +12 more
core   +1 more source

A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation

Haematologica, 2018
HLA antibodies are associated with refractoriness to platelet transfusion, leading to rapid platelet clearance, sometimes coinciding with clinical side effects such as fever and chills.
Maaike Rijkers, Anno Saris, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Ruben Bierings, Frank W.G. Leebeek, A.J. Gerard Jansen, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +11 more
doaj   +1 more source

Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation

Platelets, 2022
We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use to analyze activated but non-complexed platelets via flow cytometry.
Martina Aguiar Bucsai, Christian Idel, Barbara Wollenberg, Christine Mannhalter, Admar Verschoor   +4 more
doaj   +1 more source