Results 41 to 50 of about 4,071,532 (408)

Platelet activation in adult HIV-infected patients on antiretroviral therapy: a systematic review and meta-analysis

BMC Medicine, 2020
Background Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD).
Bongani B. Nkambule, Vuyolwethu Mxinwa, Zibusiso Mkandla, Tinashe Mutize, Kabelo Mokgalaboni, Tawanda M. Nyambuya, Phiwayinkosi V. Dludla   +6 more
doaj   +1 more source

Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis

Platelets, 2019
Platelets and Toll-like receptor (TLR) signalling play a role in the immune response during sepsis. Although preclinical knowledge about the role of platelet TLR signalling is increasing, data during human sepsis are less abundant.
Theodora A.M. Claushuis, Annelou I.P. Van Der Veen, Janneke Horn, Marcus J. Schultz, Riekelt H. Houtkooper, Cornelis Van ’T Veer, Tom Van Der Poll   +6 more
doaj   +1 more source

Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets [PDF]

, 2018
Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis.
Birnbaumer, Lutz, Bissinger, Rosi, Cao, Hang, Gawaz, Meinrad, Lang, Elisabeth, Lang, Florian, Leiss, Veronika, Nürnberg, Bernd, Pelzl, Lisann, Pieske, Burkert, Qadri, Syed M., Umbach, Anja T., Voelkl, Jakob   +12 more
core   +1 more source

Platelet activation determines the severity of thrombocytopenia in dengue infection

Scientific Reports, 2017
Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we described a direct correlation between activation and depletion of platelets in ...
Amrita Ojha, Dipika Nandi, Harish Batra, Rashi Singhal, Gowtham K. Annarapu, S. Bhattacharyya, T. Seth, L. Dar, G. Medigeshi, S. Vrati, Naval K. Vikram, P. Guchhait   +11 more
semanticscholar   +1 more source

Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation

Platelets, 2022
We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use to analyze activated but non-complexed platelets via flow cytometry.
Martina Aguiar Bucsai, Christian Idel, Barbara Wollenberg, Christine Mannhalter, Admar Verschoor   +4 more
doaj   +1 more source

Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production [PDF]

, 2017
The effect of lipopolysaccharide (LPS) on platelet aggregation is still controversial. We performed in vitro and ex vivo studies in controls and in patients with community-acquired pneumonia (CAP) to assess the effect of LPS on platelet activation (PA ...
Camilla Calvieri, Cristina Nocella, Daniele Pastori, Francesco Violi, Gijón, Marta Novo, Pasquale Pignatelli, Roberto Cangemi, Roberto Carnevale, Simona Bartimoccia   +9 more
core   +1 more source

Synergistic inhibitory effects of clopidogrel and rivaroxaban on platelet function and platelet‐dependent thrombin generation in cats

Journal of Veterinary Internal Medicine, 2023
Background Dual antithrombotic treatment (DAT) with clopidogrel and rivaroxaban sometimes is prescribed to cats with hypertrophic cardiomyopathy at risk of thromboembolism.
Sara T. Lo, Ronald H. L. Li, Catherine J. Georges, Nghi Nguyen, Cheyenne K. Chen, Claire Stuhlmann, Maureen Sigmund Oldach, Victor Noel Rivas, Samantha Fousse, Samantha P. Harris, Joshua A. Stern   +10 more
doaj   +1 more source

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]

, 2006
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
core   +1 more source

A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation

Haematologica, 2018
HLA antibodies are associated with refractoriness to platelet transfusion, leading to rapid platelet clearance, sometimes coinciding with clinical side effects such as fever and chills.
Maaike Rijkers, Anno Saris, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Ruben Bierings, Frank W.G. Leebeek, A.J. Gerard Jansen, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +11 more
doaj   +1 more source

Comparison of symmetrical hemodialysis catheters using computational fluid dynamics [PDF]

, 2015
Purpose: Symmetric-tip dialysis catheters have become alternative devices because of low access recirculation and ease of tip positioning. Flow characteristics of three symmetric catheters were compared based on computational fluid dynamics (CFD) as they
Clark, Thimothy, Gallo, Diego, Isu, Giuseppe, Morbiducci, Umberto, Verdonck, Pascal   +4 more
core   +2 more sources