Results 51 to 60 of about 4,119,343 (427)

Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production [PDF]

, 2017
The effect of lipopolysaccharide (LPS) on platelet aggregation is still controversial. We performed in vitro and ex vivo studies in controls and in patients with community-acquired pneumonia (CAP) to assess the effect of LPS on platelet activation (PA ...
Camilla Calvieri, Cristina Nocella, Daniele Pastori, Francesco Violi, Gijón, Marta Novo, Pasquale Pignatelli, Roberto Cangemi, Roberto Carnevale, Simona Bartimoccia   +9 more
core   +1 more source

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2 [PDF]

, 2008
Platelets play an essential role in wound healing by forming thrombi that plug holes in the walls of damaged blood vessels. To achieve this, platelets express a diverse array of cell surface receptors and signaling proteins that induce rapid platelet ...
Barrow, Bijsterbosch, Blake, Braselmann, Burkhardt, Chen, Christou, Cicmil, Clemetson, Daeron, de Vet, Deindl, Dhanjal, Eble, Ezumi, Fuller, Garcia, Gibbins, Grande, Inazu, Isnardi, Jones, Keren, Lerea, Maeda, Monroe, Moroi, Muraille, Newland, Newton, Nieswandt, Nieswandt, Ono, Patil, Poole, Quek, Ravetch, Reedquist, Roose, Senis, Shapiro, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Takata, Tomlinson, van Oers, Verbrugge, Vivier, Washington, Washington, Watson   +51 more
core   +3 more sources

Platelet Biochemistry and Morphology after Cryopreservation [PDF]

, 2020
Platelet cryopreservation has been investigated for several decades as an alternative to room temperature storage of platelet concentrates. The use of dimethylsulfoxide as a cryoprotectant has improved platelet storage and cryopreserved concentrates can ...
Compernolle, Veerle, Feys, Hendrik, Six, Katrijn   +2 more
core   +1 more source

Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue

PLoS Pathogens, 2017
Dengue is the most prevalent human arbovirus disease worldwide. Dengue virus (DENV) infection causes syndromes varying from self-limiting febrile illness to severe dengue.
M. Trugilho, E. D. Hottz, G. V. Brunoro, A. Teixeira-Ferreira, P. Carvalho, Gustavo A. Salazar, G. Zimmerman, F. Bozza, P. Bozza, J. Perales   +9 more
semanticscholar   +1 more source

Impact of diabetes on platelet activation in different manifestations of atherosclerosis

Swiss Medical Weekly, 2013
BACKGROUND: Atherosclerosis affects many patients with type 2 diabetes. Both are associated with platelet activation, but it remains unclear how diabetes contributes to, or even enhances, platelet activation in patients with atherosclerosis.
Thomas Gremmel, Christoph W Kopp, Daniela Seidinger, Renate Koppensteiner, Sabine Steiner, Simon Panzer   +5 more
doaj   +1 more source

Comparison of symmetrical hemodialysis catheters using computational fluid dynamics [PDF]

, 2015
Purpose: Symmetric-tip dialysis catheters have become alternative devices because of low access recirculation and ease of tip positioning. Flow characteristics of three symmetric catheters were compared based on computational fluid dynamics (CFD) as they
Clark, Thimothy, Gallo, Diego, Isu, Giuseppe, Morbiducci, Umberto, Verdonck, Pascal   +4 more
core   +2 more sources

Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis

Arteriosclerosis, Thrombosis and Vascular Biology, 2016
Objective—Reactive oxygen species (ROS) are known to regulate platelet activation; however, the mechanisms of ROS production during platelet activation remain unclear. Platelets express different isoforms of nicotinamide adenine dinucleotide (phosphate) (
M. K. Delaney, Kyungho Kim, Brian Estevez, Zheng Xu, Aleksandra Stojanovic-Terpo, Bo Shen, M. Ushio-Fukai, Jaehyung Cho, Xiaoping Du   +8 more
semanticscholar   +1 more source

GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets. [PDF]

, 2020
G protein-coupled receptors (GPCRs) mediate the majority of platelet activation in response to agonists. However, questions remain regarding the mechanisms that provide negative feedback toward activated GPCRs to limit platelet activation and thrombus ...
Benovic, Jeffrey, Brass, Lawrence F., Chen, Xi, Cooper, Matthew, DeHelian, Daniel, Goldfinger, Lawrence E., Gupta, Shuchi, Ma, Peisong, McKenzie, Steven E., Naik, Meghna U., Naik, Ulhas P., Stalker, Timothy J., Wurtzel, Jeremy G.T., Zhao, Xuefei   +13 more
core   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Berliner JA, Bittman R, Casals-Stenzal J, Esterbauer H, Fernandez-Ortiz A, Frey B, Goetzl EJ, Holvoet P, Itabe H, Kamido H, Kamido H, Kern H, Kinsella BT, Kitagawa S, O'Flaherty JT, O'Flaherty JT, Rasmussen UB, Sevanian A, Subbanagounder G, Tanaka T, Trip MD, Volf I, Watson AD, Weidtmann A   +23 more
core   +1 more source

Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release

Scientific Reports, 2016
Thrombosis and its complications are the leading cause of death in patients with diabetes. Metformin, a first-line therapy for type 2 diabetes, is the only drug demonstrated to reduce cardiovascular complications in diabetic patients.
Guang Xin, Zeliang Wei, Chengjie Ji, Huajie Zheng, Jun Gu, Limei Ma, Wenfang Huang, S. Morris-Natschke, J. Yeh, Rui Zhang, Chaoyi Qin, L. Wen, Zhihua Xing, Yu Cao, Q. Xia, Yanrong Lu, Ke Li, H. Niu, K. Lee, Wenfang Huang   +19 more
semanticscholar   +1 more source