Results 51 to 60 of about 4,112,530 (307)

Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets

Haematologica, 2019
High titers of HLA antibodies are associated with platelet refractoriness, causing poor platelet increments after transfusions in a subset of patients with HLA antibodies.
Maaike Rijkers, David Schmidt, Nina Lu, Cynthia S.M. Kramer, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Frank W.G. Leebeek, A.J. Gerard Jansen, Ilse Jongerius, Sacha S. Zeerleder, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +14 more
doaj   +1 more source

Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia. [PDF]

, 2015
BackgroundTwo congenital bleeding diatheses have been identified in Thoroughbred horses: Glanzmann thrombasthenia (GT) and a second, novel diathesis associated with abnormal platelet function in response to collagen and thrombin stimulation.Hypothesis ...
Blevins, G, Norris, JW, Pombo, M, Shirley, E, Tablin, F   +4 more
core   +1 more source

Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis.

Blood, 2015
Autophagy is important for maintaining cellular homeostasis, and thus its deficiency is implicated in a broad spectrum of human diseases. Its role in platelet function has only recently been examined.
Madhu M Ouseph, Yunjie Huang, M. Banerjee, Smita Joshi, L. MacDonald, Yu Zhong, Huijuan Liu, Xianting Li, B. Xiang, Guoying Zhang, M. Komatsu, Zhenyu Yue, Zhenyu Li, B. Storrie, S. Whiteheart, Qing Jun Wang   +15 more
semanticscholar   +1 more source

Platelet activation via dynamic conformational changes of von Willebrand factor under shear.

PLoS ONE, 2020
Shear-induced conformational changes of von Willebrand factor (VWF) play an important role in platelet activation. A novel approach describing VWF unfolding on the platelet surface under dynamic shear stress is proposed.
Denis M Pushin, Tatiana Y Salikhova, Ksenia E Zlobina, Georgy Th Guria   +3 more
doaj   +1 more source

CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation [PDF]

, 2003
CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation.
Callard, R.E., Inwald, D.P., Klein, N.J., McDowall, A., Peters, M.J.   +4 more
core  

Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-antibodies [PDF]

, 2016
Mechanisms leading to decreased platelet count in immune thrombocytopenia (ITP) are heterogeneous. This study describes increased platelet apoptosis involving loss of mitochondrial membrane potential (ΔΨm), caspase 3 activation (aCasp3) and ...
Contrufo, Geraldine, Espasandin, Yesica Romina, García, Alejandro Jorge, Glembotsky, Ana Claudia, Goette, Nora Paula, Grodzielski, Matías, Heller, Paula Graciela, Lev, Paola Roxana, Marta, Rosana Fernanda, Molinas, Felisa Concepción, Pierdominici, Marta S., Riveros, Dardo Alberto   +11 more
core   +1 more source

Platelet activation determines angiopoietin-1 and VEGF levels in malaria: implications for their use as biomarkers. [PDF]

PLoS ONE, 2014
INTRODUCTION: The angiogenic proteins angiopoietin (Ang)-1, Ang-2 and vascular endothelial growth factor (VEGF) are regulators of endothelial inflammation and integrity.
Judith Brouwers, Rintis Noviyanti, Rob Fijnheer, Philip G de Groot, Leily Trianty, Siti Mudaliana, Mark Roest, Din Syafruddin, Andre van der Ven, Quirijn de Mast   +9 more
doaj   +1 more source

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

Journal of Hematology & Oncology, 2020
Background Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at a dramatically increased lethal risk. Although platelet activation is critical for thrombosis and is responsible for the thrombotic events ...
Shenmin Zhang, Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Z. Ding, Yi Zhang, Liang Hu   +16 more
semanticscholar   +1 more source

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly [PDF]

, 2017
Significance: The incidence of cardiovascular events (CVEs) increases with age, representing the main cause of death in an elderly population. Aging is associated with overproduction of reactive oxygen species (ROS), which may affect clotting and ...
Carnevale, Roberto, Loffredo, Lorenzo, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +4 more
core   +1 more source

Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis

Science Translational Medicine, 2018
Platelet microparticles from patients with systemic sclerosis prompt endothelial cell activation, neutrophil recruitment, and lung fibrosis. Platelets nurture neutrophil damage Systemic sclerosis, or scleroderma, is a complicated inflammatory fibrotic ...
N. Maugeri, A. Capobianco, P. Rovere-Querini, G. Ramirez, E. Tombetti, P. Valle, A. Monno, V. D’Alberti, A. Gasparri, S. Franchini, A. D’Angelo, M. Bianchi, A. Manfredi   +12 more
semanticscholar   +1 more source