Results 271 to 280 of about 12,292 (326)
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Integrin-mediated platelet adhesion
Frontiers in Bioscience, 1998Adhesion of platelets to the damaged subendothelium is a prerequisite reaction for the initiation of hemostasis in vivo. Platelet membranes contain high concentrations of integrins and other glycoproteins (GPs) that are involved in the platelet adhesion to the extracellular matrix.
M, Moroi, S M, Jung
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Primary Platelet Adhesion Receptors
IUBMB Life, 2005AbstractThrombotic diseases such as heart attack and stroke remain a major health concern in the Western world despite existing anti‐thrombotic drugs. Current studies are revealing structure‐function relationships of primary platelet adhesion receptors mediating adhesion, activation and aggregation, and the molecular mechanisms underlying platelet ...
Jana, Yip +3 more
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Adhesive signaling in platelets
Current Opinion in Cell Biology, 1994The anucleate platelet must perform its hemostatic functions in the absence of transcriptional regulation. Central among these functions is cell adhesion, which is mediated by multiple specialized plasma membrane receptors. The adhesive function of one of the key receptors, integrin alpha IIb beta 3, is regulated by intracellular signals triggered by ...
S J, Shattil, M H, Ginsberg, J S, Brugge
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Thrombosis Research, 2011
Platelets play a central role in maintaining hemostasis mainly by binding to subendothelial collagen exposed upon vascular injury, thereby initiating thrombus formation. Platelets can bind directly to the exposed collagen through two major receptors i.e. the integrin a2b1 and glycoprotein (GP) VI.
Benedicte P, Nuyttens +3 more
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Platelets play a central role in maintaining hemostasis mainly by binding to subendothelial collagen exposed upon vascular injury, thereby initiating thrombus formation. Platelets can bind directly to the exposed collagen through two major receptors i.e. the integrin a2b1 and glycoprotein (GP) VI.
Benedicte P, Nuyttens +3 more
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PLATELET ADHESIVENESS IN EXPERIMENTAL SCURVY
The Lancet, 1967Abstract Scurvy was induced in weanling Hartley-Dunkin albino guineapigs by giving them a scorbutogenic diet. Blood was taken from anaesthetised scorbutic animals and from controls and platelet adhesiveness was measured by the rotating bulb method. Platelet adhesiveness was significantly diminished in the scorbutic animals.
G V, Born, H P, Wright
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Progress in hemostasis and thrombosis, 1985
Platelets do not adhere to surfaces to which flowing blood is normally exposed in vivo. When the lining of a blood vessel is altered or damaged, however, platelets do adhere to the injured site. Platelet adhesion is one of the first events in the formation of hemostatic plugs and thrombi, and plays a part in the development of atherosclerotic lesions ...
M A, Packham, J F, Mustard
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Platelets do not adhere to surfaces to which flowing blood is normally exposed in vivo. When the lining of a blood vessel is altered or damaged, however, platelets do adhere to the injured site. Platelet adhesion is one of the first events in the formation of hemostatic plugs and thrombi, and plays a part in the development of atherosclerotic lesions ...
M A, Packham, J F, Mustard
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Plasma lipoproteins mediate platelet adhesion
Biochemical and Biophysical Research Communications, 1990Platelet adhesion to VLDL, LDL, HDL, and to a mixture of purified apolipoproteins was examined. Platelets adhered to all the classes of lipoproteins tested. VLDL and the apolipoprotein mixture promoted the greatest degree of adhesion. Platelet adhesion was inhibited by addition of EDTA, RGD-containing peptides and anti-GPIIb-IIIa, monoclonal antibodies.
M A, Kowalska +2 more
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Platelet adhesion in atrial fibrillation
Thrombosis Research, 2007Increased platelet activation has been reported in nonvalvular atrial fibrillation (AF) but it remains unclear whether or not this is due to the underlying cardiovascular diseases, clinical subtype of AF and the influence of anti-thrombotic therapy.Platelet adhesion in AF patients was assessed using a 'platelet adhesion assay', and compared to both ...
Anirban, Choudhury +3 more
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Platelet adhesiveness in hyperlipidaemic subjects
Atherosclerosis, 1973Abstract Thirteen patients with hyperlipidaemia were studied on 27 occasions and various indices of platelet adhesiveness were correlated with their serum lipid levels. There was only minimal evidence that platelet adhesiveness increased in relation to high lipid levels in blood.
J C, Ferguson +2 more
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Platelet adhesion to fibrin(ogen)
Blood Coagulation & Fibrinolysis, 1993We have found that glycoprotein IIb:IIIa (GPIIb:IIIa) expressed on nonstimulated platelets is the primary receptor for platelet adhesion to immobilized fibrinogen or fibrin. At low shear rates of the blood the interaction between GPIIb:IIIa and fibrin(ogen) is strong enough to resist the shear forces exerted on the platelet as was shown with ...
S C, Endenburg +4 more
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