MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation. [PDF]
, 2018 BACKGROUND: Acute thrombotic syndromes lead to atherosclerotic plaque rupture with subsequent thrombus formation, myocardial infarction and stroke. Following rupture, flowing blood is exposed to plaque components, including collagen, which triggers ...
Farndale, Richard W +6 more
core +4 more sources
Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers [PDF]
, 2003 Background/Aim: N-6 fatty acids are considered to promote diseases prevalent in industrialized countries and characterized by an increased eicosanoid biosynthesis from arachidonic acid (AA).
Adam, Olaf, Wolfram, G., Zöllner, N.
core +1 more source
Multiscale simulation of blood flow in brain arteries with an aneurysm [PDF]
arXiv, 2011 Interfacing atomistic-based with continuum-based simulation codes is now required in many multiscale physical and biological systems. We present the first results from coupled atomistic-continuum simulations on 190,000 processors. Platelet aggregation in the patient-specific model of an aneurysm has been modeled using a high-order spectral/hp element ...
arxiv
Platelets, 2018 Antiplatelet therapies remain an area of potential interest for the treatment of sepsis; however, studies of platelet aggregation in sepsis have yielded conflicting results.
Caroline M. Larkin +6 more
doaj +1 more source
The effect of Kaempferia parviflora extracts on platelet functions in vitro [PDF]
, 2015 Kaempferia parviflora is one of Thai medicinal herbs that is used for treatment of some gastrointestinal diseases and increases libido. The effects of Kaempferia parviflora extract on platelet function in plasma were studied in 20 normal subjects.
Hnuklab, Sriamporn +1 more
core +1 more source
Effects of Taurine and Ginkgo biloba Extract on Platelet Aggregation [PDF]
, 2002 Effects of the leaf extract Ginkgo biloba, ginkgolides A and B, and the amino acid taurine (2-aminoethane sulfonic acid) on platelet aggregation was studied.
Miglis, Mitchell G
core +1 more source
Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (Coffea arabica) [PDF]
, 2020 Coffee is rich in caffeine (CF), chlorogenic acid (CGA) and phenolics. Differing types of coffee beverages and brewing procedures may result in differences in total phenolic contents (TPC) and biological activities. Inflammation and increases of platelet
Angkasith, P +6 more
core
Modeling Platelet P2Y$_1$/$_{12}$ Pathway to Integrin Activation [PDF]
arXivThrough experimental studies, many details of the pathway of integrin $\alpha_{\rm IIb}\beta_3$ activation by ADP during the platelet aggregation process have been mapped out. ADP binds to two separate G protein coupled receptors on platelet surfaces, leading to alterations in the regulation of the small GTPase RAP1.
arxiv
Air-blood interface engineered microfluidic device to mimic shear rate gradient induced human bleeding model [PDF]
arXivMicrofluidic technology has emerged as a powerful tool for studying complex biological processes with enhanced precision and control. A microfluidic chip was designed to emulate human-like microvascular networks with precise control over channel geometry and flow conditions.
arxiv
Homocysteine levels and platelet aggregation in patients with cerebral circulatory disorders
Терапевтический архив, 2013 AIM: To reveal platelet functional changes manifesting as abnormal rate of platelet aggregation in patients with acute cerebral circulatory disorders (ischemic stroke, transient ischemic attack), to evaluate the effect of homocysteine (Hc) on platelet ...
Z Sabaliauskiene +5 more
doaj