Results 81 to 90 of about 237,113 (353)

PLATELET PHAGOCYTOSIS AND AGGREGATION [PDF]

The Journal of Cell Biology, 1965
The addition of latex particles to native (no anticoagulant) or citrated human platelet-rich plasma (PRP), or to a once-washed platelet suspension causes platelet aggregation. This aggregation is associated with phagocytosis of the latex particles by the platelets and appears to be due to release of adenosine diphosphate (ADP) from the platelets ...
H Z, Movat, W J, Weiser, M F, Glynn, J F, Mustard   +3 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Reduced platelet activation and platelet aggregation in patients with alcoholic liver cirrhosis

Platelets, 2018
Results from previous studies regarding platelet function in liver cirrhosis are discordant. The aim was to investigate platelet activation and platelet aggregation in patients with alcoholic liver cirrhosis.
Pernille Just Vinholt, Anne-Mette Hvas, Christian Nielsen, Anna Cecilia Söderström, Ulrik Sprogøe, Annette Dam Fialla, Mads Nybo   +6 more
doaj   +1 more source

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

Frontiers in Immunology, 2022
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Ole-Lars Brekke, Ole-Lars Brekke   +14 more
doaj   +1 more source

Platelets at the vascular interface [PDF]

, 2018
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Bergmeier, Wolfgang, Stefanini, Lucia
core   +1 more source

Glycine reduces platelet aggregation [PDF]

Amino Acids, 2012
It has been demonstrated that a wide variety of white blood cells and macrophages (i.e. Kupffer cells, alveolar and peritoneal macrophages and neutrophils) contain glycine-gated chloride channels. Binding of glycine on the receptor stimulates Cl− influx causing membrane hyperpolarization that prevents agonist-induced influx of calcium.
Peter, Schemmer, Zhi, Zhong, Uwe, Galli, Michael D, Wheeler, Li, Xiangli, Blair U, Bradford, Lars O, Conzelmann, Dow, Forman, José, Boyer, Ronald G, Thurman   +9 more
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Effect of Oral Anti-platelet Regimens on Platelet Aggregation using Chronolog Light Transmittance Aggregometry in Coronary Heart Disease Patients: An Observational Study [PDF]

Journal of Clinical and Diagnostic Research, 2013
Introduction: Coronary heart disease is one of the most common cardiac health problem in India. Anti-platelet therapy is the cornerstone in the management of coronary heart disease.
Kishan P.V., Uday Kumar C., Shobha J.C., Usharani P., Chandrasekhar E.   +4 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]

, 2010
The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt, Atkinson, Barrow, Beata Grygielska, Bertrand Leblond, Bodin, Bodin, Boggon, Christou, Colonna, Eble, Ezumi, Fuller, He, Hooley, Hughes, Huysamen, Johannes A. Eble, Kerrigan, Laurent Désiré, Lee, Locke, May, McCarty, Pestina, Piechulek, Pierce, Pleines, Quek, Sancho, Schacht, Shutes, Simons, Sobanov, Spalton, Steve P. Watson, Suzuki-Inoue, Suzuki-Inoue, Tolias, Walliser, Watson, Watson, Wonerow, Wonerow, Xu   +44 more
core   +1 more source