Results 61 to 70 of about 237,113 (353)

Agonist-lnduced in Vitro Platelet Aggregation in Type 2 Diabetic and Non-diabetic Coronary Artery Patients

Endocrinology Research and Practice, 2022
Many patients with diabetes mellitus show increased platelet aggregation and prostaglandin synthesis m response to adenosine diphosphate (ADP) when their platelets are tested in platelet-rich plasma or washed platelet suspensions.
Abdi Sağcan, Mustafa Akın, Serdar Bedii Omay, Mehdi Zoghi, Azem Akıllı, Cüneyt Türkoğlu   +5 more
doaj   +2 more sources

Influence of Platelet Aggregation Modulators on Cyclic AMP Production in Human Thrombocytes

Folia Medica, 2018
Background: Cyclic AMP is a powerful inhibitor of platelet aggregation. In the present study we examined the effect of platelet aggregation modulators on cyclic AMP content in human thrombocytes.
Boyanov Krasimir O., Maneva Ana I.
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Coming safely to a stop : a review of platelet activity after cessation of antiplatelet drugs [PDF]

, 2015
Funding Isobel Ford is an employee of the University of Aberdeen. The research for the writing of this review received no specific grant from any funding agency in the public, commercial, or not-forprofit sectorsPeer ...
Ford, Isobel
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

THE EFFECTIVENESS OF PAPAYA LEAF EXTRACT (CARICA PAPAYA L.) AS AN ANTIAGGREGATION AGENT ON PLATELET COUNT AND PLATELET AGGREGATION: IN VITRO STUDY

Journal of Vocational Health Studies
Background: In hypertensive patients, platelet hyperaggregation may lead to acute ischemic stroke, which can increase mortality or neurological deficits.
Ganjar Noviar, Eem Hayati, Riski Nur Ramadhani   +2 more
doaj   +1 more source

PLATELET AGGREGATION PROFILE AND CARDIOVASCULAR EVENT IN CORONARY HEART DISEASE PATIENTS WITH DUAL ANTIPLATELET [PDF]

, 2016
Platelet aggregation plays an important role in atherosclerosis process in Coronary Heart Disease (CHD) patients. Antiplatelet acts to prevent platelet aggregation and thrombus subsequently. Thrombus will block artery coronaries.
., Carollina, Manda, Edlin, Parfati, Nani, Rochmawati, Ike Dhiah   +3 more
core  

cGMP-dependent protein kinase regulates Rap1 signaling in platelets : poster presentation [PDF]

, 2007
cGMP- and cAMP-dependent protein kinases (cGK and cAK) mediate the inhibitory effects of endothelium-derived messenger molecules nitric oxide and prostacyclin on platelets.
Danielewski, Oliver, Hoffmeister, Meike, Neumüller, Olga, Riha, Pavel, Schultess, Jan, Smolenski, Albert   +5 more
core   +1 more source

Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]

, 2020
Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B., Lakshminarayanan, Karthik, Layfield, Harry J., Mehmi, Amita, Patel, Ketan, Ravishankar, Divyashree, Salim, Anika, Sonavane, Medha, Trim, Steven A., Vaiyapuri, Rajendran, Vaiyapuri, Sakthivel, Vallance, Thomas M., Williams, Harry F.   +12 more
core   +1 more source

Polyamines and platelet aggregation

Life Sciences, 1976
Abstract High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents.
Division of Genetics, Endocrinology and Metabolism Departments of Pediatrics, Biochemistry and Neuroscience University of Florida, Gainesville-Sunland Research Laboratory Gainesville, Florida 32610, U.S.A. ( host institution ), Rennert, Owen ( author ), Buehler, Bruce ( author ), Miale, Thomas ( author ), Lawson, Daniel ( author )   +4 more
openaire   +3 more sources