Results 41 to 50 of about 237,113 (353)

Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner [PDF]

, 2015
Following platelet adhesion and primary activation at sites of vascular injury, secondary platelet activation is induced by soluble platelet agonists, such as ADP, ATP, thrombin and thromboxane.
Asselin, Ben R. Watson, Blake, Dominique Bihan, Emery, Faure, Forbes, Gibbins, Gibbins, Golden, Gordon, Gorodetsky, Heyns Adu, Jarvis, Jean-Daniel M. Malcor, Joanna-Marie Howes, Jung, Kehrel, Kirk A. Taylor, Knight, Konopatskaya, Mahdi, Marx, Marx, Milne, Morton, Nathan A. White, Nicholas Pugh, Onley, Pugh, Pugh, Raynal, Richard W. Farndale, Ruggeri, Sharir, Smethurst, Stadler, Stefanini, Stewart O. Sage, Trybulec, Vallee, Varga-Szabo, Xia, Zhang, Zufferey   +44 more
core   +1 more source

PLATELET AGGREGATION

The Professional Medical Journal, 2018
The herbal use for medical purposes is increasing world over. Aloe vera is onesuch herb with established anti-inflammatory action. It has great prospect in terms of replacingtraditional NSAIDS due to better side effect profile on gastrointestinal tract but its effect onplatelet aggregation is what needs to be determined.
Sidra Mushtaq, Mufakhara Fatima, Zobia Mushtaq, Roohi Manzoor Khan, Muhammad Naeem Iqbal, Sadida Aamir   +5 more
openaire   +4 more sources

Thrombospondin promotes platelet aggregation [PDF]

Blood, 1988
Abstract Thrombospondin (TSP), isolated from human platelets, promotes aggregation of both nonstimulated platelets and platelets stimulated with thrombin or ADP. The TSP-promoted aggregation is specific since a monoclonal antibody against TSP inhibits the effect of exogenously added TSP and inhibits thrombin-induced platelet aggregation ...
G P, Tuszynski, V L, Rothman, A, Murphy, K, Siegler, K A, Knudsen   +4 more
openaire   +3 more sources

Targeted deep sequencing of the PEAR1 locus for platelet aggregation in European and African American families

Platelets, 2019
Coronary artery disease (CAD) remains a major cause of mortality and morbidity worldwide. The aggregation of activated platelets on a ruptured atherosclerotic plaque is a critical step in most acute cardiovascular events like myocardial infarction ...
Ali R Keramati, Lisa R Yanek, Kruthika Iyer, Margaret A Taub, Ingo Ruczinski, Diane M Becker, Lewis C Becker, Nauder Faraday, Rasika A Mathias   +8 more
doaj   +1 more source

Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]

, 2020
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar, Banno, Bekendam, Bi, Chagas, Chagas, Chang, Chen, Chung, Dang, De Bona, Dutta-Roy, Essex, Essex, Essex, Ghoshal, Giamogante, Giamogante, Holbrook, Inoue, Jarvis, Jasuja, Jayakumar, Jordan, Kang, Kehrel, Kim, Lahav, Lakowicz, Lescano, Lin, Lu, Mangin, Masuda, Navarro-Nuñez, Park, Raffaelli, Raturi, Sharma, Sousa, Stopa, Taylor, Trnkova, Wang, Ware, Wendelboe   +45 more
core   +1 more source

No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan‐induced inhibition of platelet aggregation response

Journal of Veterinary Internal Medicine, 2023
Background A variant in the canine phosphodiesterase (PDE) 5A gene (PDE5A:E90K) is associated with decreased concentrations of circulating cyclic guanosine monophosphate (cGMP) and response to PDE5 inhibitor treatment.
Maria J. Reimann, Daniel N. Faisst, Mads Knold, Kathryn M. Meurs, Joshua A. Stern, Signe E. Cremer, Jacob E. Møller, Ingrid Ljungvall, Jens Häggström, Lisbeth H. Olsen   +9 more
doaj   +1 more source

Camel platelet aggregation responses and the antiplatelet effect of camel urine: comparison between black and white camels

Heliyon, 2020
Human black and white-skinned races exhibited differences in platelet aggregation. However, no similar differences were described on white and black camels.
Abeer Khalid Al-Ghumlas
doaj   +1 more source

Effects of electronic cigarette flavorants on human platelet aggregation ex vivo

Toxicology Reports, 2022
Because little is known about the effects of individual flavorants in electronic cigarette (e-cig) fluids on human platelet aggregation, we tested for the direct effects of 15 common e-cig flavorants on adenosine diphosphate (ADP)-induced human platelet ...
Andre Richardson, Tatiana Krivokhizhina, Pawel Lorkiewicz, Stanley D’Souza, Aruni Bhatnagar, Sanjay Srivastava, Daniel J. Conklin   +6 more
doaj   +1 more source

MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation. [PDF]

, 2018
BACKGROUND: Acute thrombotic syndromes lead to atherosclerotic plaque rupture with subsequent thrombus formation, myocardial infarction and stroke. Following rupture, flowing blood is exposed to plaque components, including collagen, which triggers ...
Farndale, Richard W, Hamaia, Samir W, Howes, Joanna-Marie, Jung, Stephanie M, Knäuper, Vera, Malcor, Jean-Daniel, Pugh, Nicholas   +6 more
core   +4 more sources

Mucor circinelloides induces platelet aggregation through integrin αIIbβ3 and FcγRIIA

Platelets, 2019
Thrombosis is a hallmark of the fatal fungal infection mucormycosis. Yet, the platelet activation pathway in response to mucormycetes is unknown. In this study we determined the platelet aggregation potential of Mucor circinelloides (M.
Harlene Ghuman, Alicia Shepherd-Roberts, Stephanie Watson, Malou Zuidscherwoude, Steve P. Watson, Kerstin Voelz   +5 more
doaj   +1 more source