Results 31 to 40 of about 38,084 (311)

Mucor circinelloides induces platelet aggregation through integrin αIIbβ3 and FcγRIIA

Platelets, 2019
Thrombosis is a hallmark of the fatal fungal infection mucormycosis. Yet, the platelet activation pathway in response to mucormycetes is unknown. In this study we determined the platelet aggregation potential of Mucor circinelloides (M.
Harlene Ghuman, Alicia Shepherd-Roberts, Stephanie Watson, Malou Zuidscherwoude, Steve P. Watson, Kerstin Voelz   +5 more
doaj   +1 more source

Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway

, 2003
Background: The regulation of platelet function by pharmacological agents that modulate platelet signaling haspharmacolo proven a successful approach to the prevention of thrombosis.
Cicmil, M, Jordan, P.A., Sage, T., C. M. Williams, G. P. Hubbard, T. Sage, Lovegrove, J.A., Stevens, J M; id_orcid, P. A. Jordan, J. M. Gibbins, Hubbard, G.P., M. Cicmil, Sage, T, Gibbins, J.M., Williams, C M, Williams, C.M., Gibbins, J M, Jordan, P A, Lovegrove, J A, Hubbard, G P, Stevens, J.M., J. A. Lovegrove, J. M. Stevens, Cicmil, M.   +23 more
core   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Siedler, F., Sellmayer, Alois, Gopfert, M. S., Siess, W.   +3 more
core   +1 more source

Methylglyoxal induces platelet hyperaggregation and reduces thrombus stability by activating PKC and inhibiting PI3K/Akt pathway

, 2013
Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases.
Voahanginirina Randriamboavonjy, Ingrid Fleming, Amro Elgheznawy, Randriamboavonjy, Voahanginirina, Fleming, Ingrid, Amro Elgheznawy (458464), Karin Hadas, Hadas, Karin, Karin Hadas (458462), Alexander Mann (262817), Elgheznawy, Amro, Mann, Alexander, Ingrid Fleming (132865), Alexander Mann, Voahanginirina Randriamboavonjy (458463)   +14 more
core   +1 more source

Shear‐dependent platelet aggregation size

, 2020
Nonsurgical bleeding is the most frequent complication of left ventricular assist device (LVAD) support. Supraphysiologic shear rates generated in LVAD causes impaired platelet aggregation, which increases the risk of bleeding.
Michael J. Simmonds, Ki, KK, Watanabe, N, Murashige, Tomotaka, Murashige, T, Chan, Chris Hoi Houng, Katrina K. Ki, John F. Fraser, Chris Hoi Houng Chan, Masataka Inoue, Geoff D. Tansley, Watanabe, Nobuo, Chan, CHH, Fraser, John F., Simmonds, Michael J., Ki, Katrina K., Inoue, M, Inoue, Masataka, Tomotaka Murashige, Tansley, Geoff D., Fraser, JF, Tansley, GD, Nobuo Watanabe, Simmonds, MJ   +23 more
core   +1 more source

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2 [PDF]

, 2008
Background: The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCc2 in platelets downstream of GPVI/FcRc and the C-type lectin receptor CLEC-2.
Pearce, AC, Watson, Steve P, Watson, Steve P., Eble, JA, Pearce, Andrew C., Pearce, A C, Hughes, C E, McGlade, Jane, Eble, Johannes A., Auger, Jocelyn; id_orcid, McGlade, J, Auger, Jocelyn M., Watson, Steve; id_orcid, Eble, J A, Pearce, Andrew C, Auger, J M, Watson, S P, Hughes, Craig, Hughes, C.E, Hughes, Craig E.   +19 more
core   +1 more source

Effects of pentoxifylline on canine platelet aggregation

Veterinary Medicine and Science, 2021
Background Pentoxifylline can decrease platelet function in humans, but the anti‐platelet effects of pentoxifylline in dogs is unknown. The addition of a luciferin–luciferase reagent during platelet aggregometry can induce a dose‐dependent potentiation ...
John M. Thomason, Todd M. Archer, Robert W. Wills, Andrew J. Mackin   +3 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Influence of Platelet Aggregation Modulators on Cyclic AMP Production in Human Thrombocytes

Folia Medica, 2018
Background: Cyclic AMP is a powerful inhibitor of platelet aggregation. In the present study we examined the effect of platelet aggregation modulators on cyclic AMP content in human thrombocytes.
Boyanov Krasimir O., Maneva Ana I.
doaj   +1 more source

Anti-platelet therapy: ADP receptor antagonists.

, 2011
The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis.
Heptinstall, S, Wijeyeratne, YD, Stan Heptinstall, Yanushi Dullewe Wijeyeratne   +3 more
core   +1 more source