Results 71 to 80 of about 237,113 (353)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
An in vitro study of the adhesion of blood platelets onto vascular catheters. Part I [PDF]
, 1987 The adhesion of human blood platelets onto vascular catheters was studied using a specially designed perfusion chamber. Polyurethane catheters were exposed to citrated human blood for different periods (up to 20 min) and at different wall shear rates ...
Aarts, P.A.M.M. +5 more
core +6 more sources
Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]
, 2018 The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Bye, Alex P. +6 more
core +4 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production [PDF]
, 2017 The effect of lipopolysaccharide (LPS) on platelet aggregation is still controversial. We performed in vitro and ex vivo studies in controls and in patients with community-acquired pneumonia (CAP) to assess the effect of LPS on platelet activation (PA ...
Camilla Calvieri +9 more
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The in vitro effect of antirheumatic drugs on platelet function
Platelets, 2020 Several antirheumatic drugs lower the cardiovascular risk among rheumatoid arthritis patients. It is, however, unknown whether inhibition of platelet function contributes to this risk reduction.
Camilla Brødsgaard Nielsen +4 more
doaj +1 more source
Platelet Activation and Aggregation Induced by Streptococcus bovis/Streptococcus equinus Complex
Microbiology Spectrum, 2022 Streptococcus bovis/Streptococcus equinus complex (SBSEC) is a common cause of infective endocarditis (IE). For IE-pathogens, the capacity to activate and aggregate platelets is believed to be an important virulence mechanism.
Gustav Pernow +4 more
doaj +1 more source
Hubungan Jumlah Trombosit Dan Nilai Agregasi Trombosit Pada Pasien Diabetes Melitus Tipe 2 Rsup Prof. Dr. R. D. Kandou Manado [PDF]
, 2014 : Patients with type 2 diabetes mellitus (T2DM) are characterized by an acceleration of thrombopoiesis, an increase of platelet turnover, and a decrease of platelet survival time. These conditions affect the platelet count that manifest as an increase of
Memah, M. F. (Maya)
core
Presence of factors that activate platelet aggregation in mitral stenotic patients' plasma [PDF]
, 2005 Background Although the association between mitral stenosis (MS) and increased coagulation activity is well recognized, it is unclear whether enhanced coagulation remains localized in the left atrium or whether this represents a systemic problem.
Istemihan Tengiz +26 more
core +2 more sources