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Integrative Approaches to Treating Cellular Senescence in Kidney Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa   +3 more
wiley   +1 more source

Evaluation of an automated platelet aggregation method for detection of congenital or acquired platelet function defects. [PDF]

open access: yesBlood Transfus
Lecchi A   +7 more
europepmc   +1 more source
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Platelet aggregation by platelet-clumping substance

Thrombosis Research, 1974
Abstract The platelet-clumping substance isolated from rabbit plasma by the authors aggregated washed rabbit platelets, while ADP did not. The presence of AMP or adenosine did not inhibit the appearance of platelet aggregation induced by the clumping substance.
H, Yamazaki   +3 more
openaire   +2 more sources

Platelet aggregation and platelet-inhibiting drugs

Neurochemical Pathology, 1987
Platelet function may cause a progression of central gray matter damage after cerebrospinal hemorrhage or trauma because of the thrombotic occlusion of injured vessels or a vasospasm induced by extravasated blood. It has therefore been suggested that antiplatelet drugs could limit the extent of the neurological lesions produced by a spinal trauma.
openaire   +2 more sources

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