Results 201 to 210 of about 195,699 (241)

Robust Controlled Degradation of Enzyme Loaded PCL‐Based Fibrous Scaffolds Toward Scarless Skin Tissue Regeneration

Advanced Science, EarlyView.
A novel biodegradable wound dressing (E‐PCLs) based on polycaprolactone (PCL) and an enzyme complex (RHP‐BCL) is developed using a fiber microfluidic electrospinning technique. The dressing achieves complete degradation within 14 days, eliminates microplastic residues, and promotes scar‐free healing (99% in 21 days).
Lingling Fan, Weiliang Dong, Jianqi Lu, Yujia Peng, Bin Xie, Ping Wei, Min Jiang, Su Chen   +7 more
wiley   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Platelet Aggregation Studies and Coagulation Profile in Sickle Cell Disease in Symptomatic and Steady State Patients. [PDF]

Indian J Hematol Blood Transfus
Nagose VB, Kodate PM, Kumbhalkar DT, Rathod SS, Nayak SP.   +4 more
europepmc   +1 more source

A Novel P-III Metalloproteinase from Bothrops barnetti Venom Degrades Extracellular Matrix Proteins, Inhibits Platelet Aggregation, and Disrupts Endothelial Cell Adhesion via α5β1 Integrin Receptors to Arginine-Glycine-Aspartic Acid (RGD)-Containing Molecules. [PDF]

Toxins (Basel)
Schluga PHC, Larangote D, de Melo AM, Lobermayer GK, Torrejón D, de Oliveira LS, Alvarenga VG, Vivas-Ruiz DE, Veiga SS, Sanchez EF, Gremski LH.   +10 more
europepmc   +1 more source

A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin.

J Postgrad Med
Pingali U, Sravanasandya P, Mekala P, Yareeda S, Sireesha K, Khan I.   +5 more
europepmc   +1 more source

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Mechanisms of platelet aggregation

Current Opinion in Hematology, 2001
Platelet aggregation is initiated by receptor activation coupled to intracellular signaling leading to activation of integrin alphaIIbbeta3. Recent advances in the study of platelet receptors for collagen, von Willebrand factor, thrombin, and adenosine diphosphate are providing new insights into the mechanisms of platelet aggregation.
B. Savage, M. Cattaneo, Z. Ruggeri
openaire   +3 more sources

Liquoid and platelet aggregation

Thrombosis Research, 1980
Abstract Liquoid, a synthetic acid polymer (sodium polyanethol sulphonate) can induce aggregation of human platelet rich plasma at concentrations ranging from 50 μg to 100 ug. Lower or higher concentrations are less effective. The aggregation of platelets which requires Ca++ is preceded by a lag phase of 30 to 60 seconds.
Kalliopi A. Kyrkou, Kalliopi A. Kyrkou, Sotirios G. Iatridis, Sotirios G. Iatridis, S.G. Markidou, S.G. Markidou, Panayotis G. Iatridis, Panayotis G. Iatridis, Dirk M. Wonnell, Dirk M. Wonnell   +9 more
openaire   +3 more sources