Results 181 to 190 of about 1,637,470 (286)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Proteomic remodeling during tumor cell-induced platelet aggregation unveils metastatic drivers in colorectal cancer. [PDF]

Cancer Cell Int
Sauer T, Gruner C, Kern K, Rackisch A, Tischner L, Schulz K, Ostermann J, Cohrs L, Kohl M, Verschoor A, Gemoll T.   +10 more
europepmc   +1 more source

Platelet Aggregation in Partially Obstructed Vessels and its Elimination with Aspirin

Circulation, 1976
John D. Folts, E. Crowell, George G. Rowe   +2 more
semanticscholar   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

Sex-related differences in platelet aggregation: rebuttal to reply. [PDF]

Eur Heart J Cardiovasc Pharmacother
Cattaneo M.
europepmc   +1 more source

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

TGFβ enhances platelet-breast-cancer-cell interaction and promotes platelet aggregation. [PDF]

FEBS J
Genitoni M, Merolle L, Razzoli A, Maurizi E, Gavioli G, Baricchi R, Marraccini C, Schiroli D.   +7 more
europepmc   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Impact of pneumatic tube vs. bicycle courier transport on platelet aggregation: influence of sex and diabetes. [PDF]

Front Med (Lausanne)
Hohneck A, Kliemank E, Bach S, Brings S, Seebauer L, Roshan M, Kender Z, Kopf S, Frey N, Zorn M, Woerner SM, Fleming T, Szendroedi J.   +12 more
europepmc   +1 more source

Nanoparticle‐induced platelet aggregation and vascular thrombosis

British Journal of Pharmacology, 2005
A. Radomski, P. Jurasz, D. Alonso-Escolano, M. Drews, M. Morandi, T. Malinski, M. Radomski   +6 more
semanticscholar   +1 more source