Results 171 to 180 of about 1,637,470 (286)

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Dark-Pi Imaging System Permits Open-Source Label-Free Microfluidic Monitoring of Platelet Aggregation by Cellular Light Scattering. [PDF]

Sensors (Basel)
Sarıyer Oglago RM, Bye AP, Dönmez Eryılmaz Sİ, Jones CI, Edwards AD.   +4 more
europepmc   +1 more source

Atorvastatin Reduces the Ability of Clopidogrel to Inhibit Platelet Aggregation: A New Drug–Drug Interaction

Circulation, 2003
Wei C. Lau, L. Waskell, P. Watkins, Charlene J. Neer, K. Horowitz, Amy S. Hopp, A. Tait, D. Carville, K. Guyer, E. Bates   +9 more
semanticscholar   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Aspirin Dosing Frequency and Dose Influence Thromboxane Suppression Despite Uniform Inhibition of Arachidonic Acid-induced Platelet Aggregation. [PDF]

TH Open
Eikelboom JW, Anand SS, Sloane DA, Hirsh J, Tran HA, Yi Q, Weitz JI.   +6 more
europepmc   +1 more source

Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation.

Proceedings of the National Academy of Sciences of the United States of America, 1974
M. Hamberg, Jan Svensson, T. Wakabayashi, B. Samuelsson   +3 more
semanticscholar   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Bisphenols-enhanced platelet aggregation via TP, P2Y₁₂, PAR1 and PAR4 receptors: a thrombotic legacy in a plastic-ubiquitous world. [PDF]

Front Pharmacol
Kwame OE, de la Peña-Díaz A, Martínez-Jiménez YI, Flores-García M, Calderón-Aranda ES, Lee-Rivera I, Gómez R.   +6 more
europepmc   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Purification and Characterization of Novel Collagen Peptides from <i>Oncorhynchus mykiss</i> Inhibiting Platelet Aggregation, and the Underlying Mechanism via Molecular Docking. [PDF]

Foods
Liu H, Zhang L, Zeng Z, Wang X, Li B.
europepmc   +1 more source