Results 151 to 160 of about 237,113 (353)

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Elderly patients are hyperresponsive to potent P2Y12 inhibitors

Research and Practice in Thrombosis and Haemostasis
Background: Aging has recently been associated with increased basal platelet activation and platelet hyperreactivity in response to adenosine diphosphate (ADP) but with decreased platelet response to thrombin receptor stimulation in individuals without ...
David Mutschlechner, Maximilian Tscharre, Patricia Pia Wadowski, Silvia Lee, Joseph Pultar, Constantin Weikert, Simon Panzer, Thomas Gremmel   +7 more
doaj   +1 more source

Fibrinogen and ADP-induced platelet aggregation [PDF]

, 1978
J. F. Mustard, MA Packham, RL Kinlough-Rathbone, DW Perry, E. Regoeczi   +4 more
openalex   +1 more source

Copolymers of Poly(Butylene Trans‐1,4‐Cyclohexanedicarboxylate)/Pripol as New Biomaterial Platform for Small Diameter Vascular Graft

Advanced Healthcare Materials, EarlyView.
Electrospun tubular scaffolds from novel PBCE‐based copolyesters and blends were designed as candidates for small‐diameter vascular grafts. They combine defect‐free architecture, blood‐compatible surfaces, and mechanical properties comparable to native vessels.
Edoardo Bondi, Gabriele Obino, Giulia Guidotti, Alberto Sensini, Martijn van Griensven, Antonio Junior Lepedda, Nadia Lotti, Lorenzo Moroni   +7 more
wiley   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

The Recent History of Platelets in Thrombosis and Other Disorders [PDF]

, 2005
The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 25 November 2003. Introduction by Professor Tom Meade, London School of Hygiene and Tropical Medicine.First published by the Wellcome ...
Reynolds, LA, Tansey, EM
core  

New platelet aggregation inhibitors.

, 1989
Akira Kawashima, Yuko Kishimura, Masaharu Tamai, Kazunori Hanada   +3 more
openalex   +2 more sources

ADP-induced platelet aggregation depends on the conformation or availability of the terminal gamma chain sequence of fibrinogen. Study of the reactivity of fibrinogen Paris 1 [PDF]

, 1987
M-H Denninger, Martine Jandrot‐Perrus, J Elion, O Bertrand, GA Homandberg, MW Mosesson, MC Guillin   +6 more
openalex   +1 more source

Thrombocytopathies: Not Just Aggregation Defects—The Clinical Relevance of Procoagulant Platelets [PDF]

, 2021
Alessandro Aliotta, Debora Bertaggia Calderara, Maxime G. Zermatten, Matteo Marchetti, Lorenzo Alberio   +4 more
openalex   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source