Results 81 to 90 of about 232,382 (353)

Study the Effect of an Antipyretic Drug, Thai Herbal Ha-Rak Formula on Platelet Aggregation in Healthy Thai Volunteers: A Randomized, Placebo - Controlled Trial

Siriraj Medical Journal, 2017
Background: Fever may alter platelet homeostasis leading to bleeding tendency. Thai herbal Ha-rak formula (HRF), a traditional Thai remedy consisting of five medicinal plants, is indicated for relieving fever.
Weerawadee Chandranipapongse, M.D., Titchaporn Palo, M.Sc.*, Sirikul Chotewuttakorn, M.Sc., Pinpat Tripatara, M.D., Ph.D., Suksalin Booranasubkajorn, Ph.D., Tawee Laohapand, M.D., Ph.D., Pravit Akarasereenont, M.D., Ph.D.   +6 more
doaj   +3 more sources

Modulatory Efficiency of Vitamin C (Ascorbic Acid) on Collagen-Induced Platelet Aggregation and Dysfunction

Biology, Medicine & Natural Product Chemistry
Platelet aggregation, coagulation, and activation are crucial for hemostasis. Collagen treatment can impair hemostatic processes leading to bleeding disorders like thrombosis; vitamin C may mitigate these effects.  Hence, modulatory efficiency of vitamin
Osah Martins Onwuka, Chukwukadibie Adigwe, Oghenefego Michael Adheke, Chamberlin Jamike Elem, Josiah Soipiriala Hart   +4 more
doaj   +1 more source

Evaluation of an automated light transmission aggregometry

Platelets, 2017
Light transmission aggregometry (LTA) is the “gold standard” for platelet function assessment, but it is time-consuming and labor intensive. Recently, an automated platelet aggregation method has been developed on a routine coagulation analyzer (Sysmex ...
Li-qin Ling, Juan Liao, Qian Niu, Xia Wang, Jin Jia, Cheng-hua Zuo, Hong Jiang, Jing Zhou   +7 more
doaj   +1 more source

Quebec platelet disorder [PDF]

, 2010
A case of Quebec platelet disorder is hereby reported. A 33 years old woman presented with history of epistaxis and gum bleeding since childhood and menorrhagia and bleeding per vaginum after puberty, also had history of excessive blood loss after birth ...
Abbasi, Anwar Hussain, Hussain, Syed Ather, Shaikh, Quratulain   +2 more
core   +1 more source

Adiponectin diminishes platelet aggregation and sCD40L release. Potential role in the metabolic syndrome [PDF]

, 2010
The proinflammatory and proatherogenic mediator, soluble CD40 ligand (CD40L), is increased in the metabolic syndrome (MS) and released from platelets. We hypothesized that adiponectin modulates platelet function, and we sought to evaluate the association
Colina, I. (Inmaculada), Restituto, P. (Patricia), Varo, J.J. (José Javier), Varo-Cenarruzabeitia, M.N. (Miren Nerea)   +3 more
core   +1 more source

Glycine reduces platelet aggregation [PDF]

Amino Acids, 2012
It has been demonstrated that a wide variety of white blood cells and macrophages (i.e. Kupffer cells, alveolar and peritoneal macrophages and neutrophils) contain glycine-gated chloride channels. Binding of glycine on the receptor stimulates Cl− influx causing membrane hyperpolarization that prevents agonist-induced influx of calcium.
Zhi Zhong, Zhi Zhong, Dow Forman, Uwe Galli, Blair U. Bradford, Lars O. Conzelmann, Michael D. Wheeler, Peter Schemmer, José L. Boyer, Li Xiangli, Ronald G. Thurman   +10 more
openaire   +3 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on αIIbβ3 and platelet secretion

Platelets, 2021
Fucosylated glycosaminoglycan (FG) from sea cucumbers has been reported to have anticoagulant effects via targeting intrinsic tenase. However, FG from natural source also potentially poses risks due to its FXIIa activation and platelet aggregating ...
Lisha Lin, Lian Yang, Jun Chen, Lutan Zhou, Sujuan Li, Na Gao, Jinhua Zhao   +6 more
doaj   +1 more source

Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics [PDF]

, 2017
Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial cells (ECs), thrombin dynamically regulates
Hoogendijk, Arie J., Meijer, Alexander B., Mertens, Koen, Simpson, Pelle J., van Alphen, Floris P.J., van den Biggelaar, Maartje, van den Eshof, Bart L., Zanivan, Sara   +7 more
core   +2 more sources

Effects of Non‐Aspirin Nonsteroidal Anti‐Inflammatory Drugs on Acute Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite celecoxib, a cyclooxygenase‐2 inhibitor, promoting functional recovery from intracerebral hemorrhage (ICH) by reducing inflammation‐mediated perihematomal edema in rat models, the evidence of its effects on patient outcomes remains limited.
Shin‐Joe Yeh, Sung‐Chun Tang, Li‐Kai Tsai, Jiann‐Shing Jeng   +3 more
wiley   +1 more source