Results 111 to 120 of about 237,328 (413)

Novel compounds of hybrid structure pyridazinone–coumarin as potent inhibitors of platelet aggregation [PDF]

Aim: The current limitations of antiplatelet therapy promote the search for new antithrombotic agents. Here we describe novel platelet aggregation inhibitors that combine pyridazinone and coumarin scaffolds in their structure.
Besada Pereira, Pedro, Cano Rubio, Ernesto, Costas Lago, Maria Del Carmen, Terán Moldes, María del Carmen   +3 more
core   +1 more source

Systematic review and meta-analysis of optimal P2Y₁₂ blockade in dual antiplatelet therapy for patients with diabetes with acute coronary syndrome [PDF]

, 2016
Background: Patients with diabetes are at increased risk of acute coronary syndromes (ACS) and their mortality and morbidity outcomes are significantly worse following ACS events, independent of other comorbidities.
Brown, Oliver I, Hoye, Angela, Rossington, Jennifer A   +2 more
core   +1 more source

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source

Platelet aggregation during targeted temperature management after out-of-hospital cardiac arrest: A randomised clinical trial

Platelets, 2018
Some studies conclude that mild hypothermia causes platelet dysfunction leading to an increased bleeding risk, whereas others state that platelet aggregation is enhanced during mild hypothermia.
Anni Nørgaard Jeppesen, Anne-Mette Hvas, Anders Morten Grejs, Christophe Duez, Susanne Ilkjær, Hans Kirkegaard   +5 more
doaj   +1 more source

A physical description of the adhesion and aggregation of platelets [PDF]

arXiv, 2015
The early stages of clot formation in blood vessels involve platelets adhesion-aggregation. Although these mechanisms have been extensively studied, gaps in their understanding still persist. We have performed detailed in-vitro experiments and developed a numerical model to better describe and understand this phenomenon.
arxiv  

Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents? [PDF]

, 2006
It has been postulated that endothelial cell injury is the initiating event in the pathogenesis of systemic sclerosis, causing attraction, attachment, migration and infiltration of activated T-cells and subsequent production of cytokines and growth ...
Derk, Chris T., Jimenez, Sergio A.
core   +2 more sources

Electrically Insulating Electromagnetic Interference Shielding Materials: A Perspective

Advanced Functional Materials, EarlyView.
Developing electromagnetic interference (EMI) shielding materials with inherent electrical insulation and high EMI shielding effectiveness is challenging but important for electronic applications. This perspective summarizes the recent advancements in designing electrically insulating EMI shielding materials and discusses the underlying mechanisms of ...
Ji Liu, Valeria Nicolosi
wiley   +1 more source

Intrahospital switch of the P2Y12 inhibitors in patients with ST segment elevation myocardial infarction in ‘real-life’ clinical practice: the effect on the functional activity of thrombocytes and thrombocytopoiesis, prognostic value

Кардиоваскулярная терапия и профилактика, 2019
Aim. To assess the P2Y12 inhibitors switch in patients ST segment elevation myocardial infarction (STEMI) in real-life’ clinical practice, evaluate the functional activity of thrombocytes and thrombocytopoiesis and determine the clinical and prognostic ...
L. I. Malinova, P. V. Dolotovskaya, N. F. Puchinyan, V. V. Furman   +3 more
doaj   +1 more source

The effect of smoking on residual platelet reactivity to clopidogrel: a systematic review and meta-analysis

Platelets, 2020
Cigarette smoking is an important cardiovascular risk factor, causing morbidity and mortality. There are many original studies on the impact of smoking, but its influence on platelet ADP-P2Y12 receptor inhibitors lack consistency.
Zhiyan Liu, Qian Xiang, Guangyan Mu, Qiufen Xie, Shuang Zhou, Zining Wang, Shuqing Chen, Kun Hu, Yanjun Gong, Jie Jiang, Yimin Cui   +10 more
doaj   +1 more source

A comparison of platelet aggregation produced by seven compounds and a comparison of their inhibitors

Journal of Clinical Pathology, 1964
The aggregating effects of adenosine diphosphate, thrombin, 5-hydroxytryptamine, tryptamine, adrenaline and noradrenaline, and tri-ethyl tin have been carefully compared.
J. R. O'brien
semanticscholar   +1 more source