Results 121 to 130 of about 218,065 (393)

Rationale for the use of platelet aggregation inhibitors in PAD patients [PDF]

Vascular Medicine, 2001
Peripheral arterial disease (PAD) is a major risk marker for systemic ischaemic events. The understanding of PAD has moved from PAD as an organ-specific disease to PAD as the lower-limb localization of a multifocal disease, i.e. atherothrombosis. Blood platelet activation and aggregation is a common denominator in atherothrombotic events, and use of ...
openaire   +4 more sources

Nitric Oxide‐Releasing Catheters with Phenol‐Amine Catalytic Coatings for Improved Anti‐Inflammatory Performance

Advanced Healthcare Materials, EarlyView.
Tannic acid‐selenocystamine (TA‐SeCA) nanocoating enables stable, sustained catalytic nitric oxide (NO) release on catheter surfaces. This one‐step phenol‐amine coating improves catheter functionality by enhancing endogenous NO production, supporting vascular function, and reducing inflammation.
Qingqing Fan, Shu Geng, Tanveer A. Tabish, Kang Lin, Yiyi Yin, Siti Nur Asyura Adzlan, Federico Mazur, Rona Chandrawati   +7 more
wiley   +1 more source

Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists

Drug Design, Development and Therapy, 2015
Nadia Khan,1,2 Ahsana Dar Farooq,1 Bassem Sadek21Dr Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan; 2Department of Pharmacology and  ...
Khan N, Farooq AD, Sadek B
doaj  

Differences and similarities in the effects of ibrutinib and acalabrutinib on platelet functions

Haematologica, 2019
While efficient at treating B-cell malignancies, Bruton tyrosine kinase (BTK) inhibitors are consistently reported to increase the risk of bleeding. Analyzing platelet aggregation response to collagen in platelet-rich plasma allowed us to identify two ...
Jennifer Series, Cédric Garcia, Marie Levade, Julien Viaud, Pierre Sié, Loïc Ysebaert, Bernard Payrastre   +6 more
doaj   +1 more source

Parmodulins Inhibit Thrombus Formation Without Inducing Endothelial Injury Caused by Vorapaxar [PDF]

, 2015
Protease-activated receptor-1 (PAR1) couples the coagulation cascade to platelet activation during myocardial infarction and to endothelial inflammation during sepsis. This receptor demonstrates marked signaling bias.
Ahn, Andrade-Gordon, Andrews, Bae, Bae, Bae, Bernatowicz, Capodanno, Chackalamannil, Chandra C. Ghosh, Chris Dockendorff, Christian G. Peters, Connolly, Covic, Dockendorff, Dowal, Garcia, Griffin, James R. Dilks, Karen De Ceunynck, Kataoka, Katritch, Knezevic, Kosoglou, Kosoglou, Lee, Matsuoka, May, McCoy, Mingdong Huang, Moers, Morrow, Mosnier, Mosnier, Mosnier, Nicholls, Offermanns, Omozuanvbo Aisiku, O’Callaghan, O’Donoghue, Riewald, Riewald, Robert Flaumenhaft, Salchow, Samir M. Parikh, Susanna F. Fustolo-Gunnink, Swift, Taylor, Tressel, Tricoci, Vanhoorelbeke, Wiviott, Zhang   +52 more
core   +2 more sources

Novel Drug‐Testing Platform for Vascular Injury‐induced Intimal Hyperplasia Using a Microphysiological System

Advanced Healthcare Materials, EarlyView.
This study develops a 3D vascular injury model using a microphysiological system that mimics key features of intimal hyperplasia. Antiproliferative drugs reduced VSMC proliferation but worsened endothelialdenudation. A combination of diphenyleneiodonium and quercetin effectively reduced proliferation and migration of VSMC and inflammation while ...
Ungsig Nam, HyeMi Kim, Jeong Ah Kim, Ki‐Hwan Nam, Kye‐Sung Lee, Hwan Hur, Jessie S. Jeon, Ji Yong Bae   +7 more
wiley   +1 more source

ChemInform Abstract: Synthesis and Properties of Peptidomimetics: Inhibitors of Platelet Aggregation

ChemInform, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. A. Krysko, T. A. Kabanova, S. A. Andronati, V. M. Kabanov, T. L. Karaseva   +4 more
openaire   +3 more sources

Guided Bone Regeneration Membrane Materials Loaded with Chimeric Nanovesicles Promote Early Bone Defect Regeneration

Advanced Healthcare Materials, EarlyView.
Early bone regeneration is challenged by poor osteogenic microenvironments. We developed a novel guided bone regeneration (GBR) membrane: a plasma‐treated polycaprolactone (PT‐PCL) electrospun nanofiber functionalized with ultrasound sequentially extruded stromal vascular fraction chimeric vesicles (USE‐SCNVs). USE‐SCNVs require less equipment, enhance
Yufan Zhang, Yaqiong Wang, Xiaona Ning, Guichu Yue, Wenhui Zhang, Yicheng Chen, Xuelian Jia, Yu Zhang, Xiao Zhang, Zihan Lu, Simin Zhu, Fuwei Liu, Yong Zhao, Liang Kong   +13 more
wiley   +1 more source

Effects of combined parenchymal and vascular injury on platelet aggregation in pial arterioles of living mice: evidence for release of aggregate-inhibiting materials. [PDF]

, 1977
William I. Rosenblum, Farouk El‐Sabban
openalex   +1 more source

ROS‐Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing

Advanced Healthcare Materials, EarlyView.
A reactive oxygen species (ROS) scavenging and immunomodulatory microneedle patch based on hyaluronic acid methacrylate (HaMA) and Flightless I (Flii)‐siRNA‐laden arginine functionalized poly (β‐amino ester)/alginate particles is developed for chronic wound healing applications.
Mahshid Kharaziha, Sahar Salehi, Mahshid Shokri, Seyed Mohsen Ahmadi Tafti, Thomas Scheibel   +4 more
wiley   +1 more source