Stent thrombosis associated with non-response to clopidogrel despite co-administration of aspirin and ibrutinib. [PDF]
Eur Heart J Case RepDirir O +4 more
europepmc +1 more source
Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation
Advanced Science, EarlyView.Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao +10 more
wiley +1 more source
Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung
Advanced Science, EarlyView.Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu +11 more
wiley +1 more source
Hemostasis-Sparing Antiplatelet Therapy: Current Concepts and Emerging Targets in Arterial Thrombosis. [PDF]
Biomol Ther (Seoul)Park JW, Oh EB, Chang TS.
europepmc +1 more source
Advanced Science, EarlyView.This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng +7 more
wiley +1 more source
Phytochemical Profiling, Antiplatelet Potential, and Cytotoxic Assessment of Thymelaea tartonraira Aerial Part Essential Oil: In Vitro and In Silico Studies. [PDF]
Chem BiodiversSoltani S +8 more
europepmc +1 more source
Advanced Science, EarlyView.Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak +6 more
wiley +1 more source
Allosteric and ATP-Pocket BCR::ABL1 Inhibition In Vitro, and Characterising Ex Vivo Thrombo-Inflammatory Biomarkers and Thrombin Generation in Asciminib-Treated CML Patients. [PDF]
Int J Mol SciOmar MMA +4 more
europepmc +1 more source
Advanced Science, EarlyView.Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang +10 more
wiley +1 more source
Platelet mitochondria dysfunction in diabetes mellitus: mechanisms and therapeutic implications. [PDF]
Front PharmacolYadava S +5 more
europepmc +1 more source