Results 181 to 190 of about 1,158,143 (284)

The patient behind the tumour: Host-related factors as determinants of immunotherapy efficacy in advanced cSCC. [PDF]

J Eur Acad Dermatol Venereol
Ruiz ES, Silk AW.
europepmc   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

PCSK9 Inhibitor Attenuates Platelet TLR4 in ACS and TLR4 Blockers Prevent PCSK9-Mediated Platelet Activation. [PDF]

Acta Cardiol Sin
Qi L, Yuan M, Liu X, Liu T, Zhang Y, Chen K.   +5 more
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Endothelial and platelet dysfunction in systemic sclerosis with pulmonary hypertension. [PDF]

PLoS One
Imerbtham T, Sriwantana T, Ngamjanyaporn P, Sotananusak T, Ngammisri P, Trerayapiwat K, Dumrongkitchaiporn P, Pisitkun P, Srihirun S, Vivithanaporn P, Sibmooh N.   +10 more
europepmc   +1 more source

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source

Pharmacodynamic effects of cangrelor in patients with or without STEMI undergoing percutaneous coronary intervention: insights from the POMPEII study. [PDF]

Eur Heart J Acute Cardiovasc Care
Gargiulo G, Narciso V, Forzano I, Sperandeo L, Castiello DS, Simonetti F, Manzi L, Florimonte D, Canonico ME, Avvedimento M, Paolillo R, Spinelli A, Di Serafino L, Spaccarotella CAM, Franzone A, Piccolo R, Stabile E, Cirillo P, Valgimigli M, Esposito G.   +19 more
europepmc   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Podoplanin-positive extracellular vesicles in ovarian cancer: linking thrombosis, platelet crosstalk, and cancer stemness - a narrative review. [PDF]

Ann Med Surg (Lond)
Beniwal SS, Tali R, Munshi SS, Patel YK, Zainab, Mohamed D, Alhamsa A, Jeong Y, Dahiya P, Ribeiro da Costa REA, Mwaanga C, Mishra A.   +11 more
europepmc   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source