Results 191 to 200 of about 54,964 (304)

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

Pharmacological Management of Peptic Ulcer Bleeding. [PDF]

Korean J Helicobacter Up Gastrointest Res
Lee H, Chung JW, Kim KO, Kwon KA, Kim JH.   +4 more
europepmc   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Effects of Cape Cobra (<i>Naja nivea</i>) Venom and Its Isolated Protein on the Modulation of Platelet Activation. [PDF]

Toxins (Basel)
Khatibi M, Almeida JR, Al Juwaiser A, Gilabadi S, Patel K, Vaiyapuri S.   +5 more
europepmc   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Rosa rubiginosa L. Extract Rich in Bioactive Phenolics Possess Potent Anti-Inflammatory, Antioxidant, Photoprotective, and Antimicrobial Biofunctional Activities. [PDF]

Chem Biodivers
Letsiou S, Kyratzi K, Tsakni A, Kranas D, Pavlidis K, Ofrydopoulou A, Halvatsiotis P, Houhoula D, Tsoupras A.   +8 more
europepmc   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Aspirin Dosing Frequency and Dose Influence Thromboxane Suppression Despite Uniform Inhibition of Arachidonic Acid-induced Platelet Aggregation. [PDF]

TH Open
Eikelboom JW, Anand SS, Sloane DA, Hirsh J, Tran HA, Yi Q, Weitz JI.   +6 more
europepmc   +1 more source

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, EarlyView.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

Effect of sildenafil on platelet activation and mediators of vascular remodelling during LVAD support. [PDF]

ESC Heart Fail
Saeed O, Patel SR, Farooq M, Reyes Gil M, Solorzano C, Afrifa F, Xue X, Ramos JO, Vukelic S, Madan S, Rochlani Y, Murthy S, Sims DB, Shin J, Goldstein DJ, Sibinga N, Yazdanbakhsh K, Kizer JR, Jorde UP.   +18 more
europepmc   +1 more source