Results 211 to 220 of about 51,821 (267)
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Lebetin Peptides: Potent Platelet Aggregation Inhibitors
Pathophysiology of Haemostasis and Thrombosis, 2001Lebetins from <i>Macrovipera lebetina</i> snake venom constitute a new class of inhibitors of platelet aggregation. There are two groups of peptides: lebetin 1 (L1; 11- to 13-mer) and lebetin 2 (L2; 37- to 38-mer). The short lebetins are identical to the N-terminal segments of the longer ones.
N, Marrakchi +6 more
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Thienopyrimidine-based P2Y12 platelet aggregation inhibitors
Bioorganic & Medicinal Chemistry Letters, 2009Herein we describe the design and synthesis of a novel series of potent thienopyrimidine P2Y12 inhibitors and the negative impact protein binding has on the inhibition of platelet aggregation.
Steven W, Kortum +7 more
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Platelet aggregation inhibitors in neurology
Pharmacy World & Science, 1993This literature review reports on secondary prevention of ischaemic stroke. The aim of secondary prevention is to protect patients who belong to a risk group from the occurrence of brain infarction. Symptomatic patients with a demonstrated carotid artery stenosis of 70% and more will most probably benefit from carotid endarterectomy if performed by a ...
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Prostaglandins as Inhibitors of Human Platelet Aggregation
British Journal of Haematology, 1979Summary. The potencies of prostaglandins (PG) I2, PGD2 and PGE1 as inhibitors of human platelet aggregation induced by threshold concentrations of four aggregating agents were determined in platelet‐rich plasma from normal individuals who had not ingested aspirin. The order of activity against ADP, adrenaline and collagen was always PGI2 > PGD2 >
DI MINNO, GIOVANNI +2 more
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New carbamoylpiperidines as human platelet aggregation inhibitors
Bioorganic & Medicinal Chemistry, 2000A series of 3-carbamoylpiperidines (nipecotamides) are designed, synthesized and tested for their inhibitory action against adenosine diphosphate (ADP)-induced aggregation of human platelets. A structure-activity analysis of the bis(nipecotamido)aralkane type showed that a substituent on the piperidine ring should preferably be an amide and that the ...
Z, Guo +4 more
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Inhibitors of platelet aggregation from onion
Phytochemistry, 1990Abstract Five new sulphur-containing compounds and five diastereoisomers which indicated potent inhibitory efrects for collagen-induced aggregation of human platelets in vitro as well as ADP- or arachidonate-induced aggregation were isolated from onion. All isolated compounds have a 1-(methylsulphinyl)-propyl alkyl (or alkenyl) disulphide skeleton.
Yasujiro Morimitsu, Shunro Kawakishi
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[Imidazole derivatives, platelet aggregation inhibitors].
Annales pharmaceutiques francaises, 1998Study of the platelet aggregation inhibition has shown the efficiency of compounds with imidazole ring alone or fused. All the compounds resulting of the molecular design starting from these structures has an in vitro activity. We have been able to discuss the correlation existing between activities, toxicities and structures with a particular emphasis
N, Sergueeva +3 more
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Inhibitors of “spontaneous” platelet aggregation in whole blood
Atherosclerosis, 1985In vitro 'spontaneous' platelet aggregation has been studied in whole blood. The spectrum of activity of materials known to influence platelet aggregation in platelet-rich plasma proved different in whole blood. Thus dipyridamole and one of its analogues SH1242 had a striking effect in whole blood whilst aspirin, chlorpromazine and K3920 had little or ...
M J, Harrison +3 more
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