Results 221 to 230 of about 52,658 (264)

Effect of Inhibitors of Aggregation on Platelet Ultrastructure in Vitro

Thrombosis and Haemostasis, 1969
SummaryElectron microscopy observations are presented on the effect of inhibitors of aggregation on platelet morphology. Moreover the relationship existing between shape changes produced by inhibitors of platelet aggregation and the mechanism of inhibition has also been studied.Among the inhibitors, nucleotides were without effect on platelet shape, so
P M, Mannucci, F, Sirigu
openaire   +2 more sources

Bleeding in a Patient Receiving Platelet Aggregation Inhibitors

Anesthesia & Analgesia, 2001
We describe a patient who experienced intraoperative bleeding after being treated with platelet receptor glycoprotein IIb/IIIa antagonist eptifibatide. We used Sonoclot and Thrombelastograph to monitor antiplatelet effects of eptifibatide.
J H, Waters, D G, Anthony, A, Gottlieb, J, Sprung   +3 more
openaire   +2 more sources

Platelet turnover in metastatic cancer and the effect of platelet aggregation inhibitors

Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1976
Patients with metastatic cancer have a permanent shortening of platelet survival and increased platelet consumption. Acetylsalicylic acid or dipyridamole in doses known to inhibit platelet aggregation, had no effect on platelet consumption.
openaire   +2 more sources

New carbamoylpiperidines as human platelet aggregation inhibitors

Bioorganic & Medicinal Chemistry, 2000
A series of 3-carbamoylpiperidines (nipecotamides) are designed, synthesized and tested for their inhibitory action against adenosine diphosphate (ADP)-induced aggregation of human platelets. A structure-activity analysis of the bis(nipecotamido)aralkane type showed that a substituent on the piperidine ring should preferably be an amide and that the ...
Z, Guo, X, Zheng, W, Thompson, M, Dugdale, R, Gollamudi   +4 more
openaire   +2 more sources

Cardamom extract as inhibitor of human platelet aggregation

Phytotherapy Research, 2005
The inhibitory activity of cardamom extract was studied on human platelets. Platelet aggregation and lipid peroxidation were evaluated with platelet rich plasma (PRP) and platelet membranes, respectively, obtained from blood of healthy volunteers.
W Jessie, Suneetha, T P, Krishnakantha
openaire   +2 more sources

A Circulating Inhibitor of Platelet Aggregation in Bartter's Syndrome

Pediatrics, 1979
Aggregation studies were performed on platelets from five patients with Bartter's syndrome. Epinephrine failed to induce aggregation in all five patients. Adenosine 5'-diphosphate (ADP) produced a single reversible phase of aggregation, and there was depressed sensitivity to collagen. Response to ristocetin was normal.
S O, O'Reagan, G E, Rivard, J G, Mongeau, P O, Robitaille   +3 more
openaire   +2 more sources

Enantioselective Synthesis of Imperanene, a Platelet Aggregation Inhibitor

Organic Letters, 2001
Both enantiomers of imperanene, a platelet aggregation inhibitor, have been synthesized in 82-90% ee. The key step of establishing the chiral center was achieved through stereoselective alkylation with benzyl chloromethyl ether using Enders' RAMP/SAMP chiral auxiliary method.
J C, Shattuck, C M, Shreve, S E, Solomon
openaire   +2 more sources

PLATELET AGGREGATION INHIBITOR IN GARLIC

The Lancet, 1981
T, Ariga, S, Oshiba, T, Tamada
openaire   +2 more sources

[Mechanism of action of platelet aggregation inhibitors].

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 2005
The antiaggregant drugs class is registering in the last few years an increased dynamics. The action mechanism relies either on the platelet activator pathway inhibition, or on the natural inhibitory pathway stimulation. The most frequently implied action mechanisms are COX inhibition, the cyclic nucleotides synthesis inhibition, ADP receptor's ...
Roxana Irina, Iancu, M, Nechifor
openaire   +1 more source

New Platelet Aggregation Inhibitors

Hämostaseologie, 1997
R. Verhaeghe, J. Vermylen
openaire   +1 more source