Results 241 to 250 of about 54,964 (304)

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Management of Tacrolimus-induced thrombotic microangiopathy in a heart transplant recipient: Utilizing novel immunosuppression strategies. [PDF]

JHLT Open
Girandon Sušanj P, Okrajšek R, Frljak S, Zemljič G, Cerar A, Šebeštjen M, Ugovšek S, Bajec T, Poglajen G.   +8 more
europepmc   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Chemical‐Biological Fixation for Enhanced Bone Augmentation in Guided Bone Regeneration

Advanced Science, EarlyView.
M2N2ACa is an innovative injectable thermoresponsive barrier membrane adhesive to achieve reliable bone graft fixation. It provides strong wet adhesion and promotes the bio‐stabilization mediated by coagulation through controlled calcium release. This dual‐fixation strategy combines external chemical fixation and internal biological fixation via clot ...
Yu‐zhu Wang, Gao‐peng Dang, Zhi‐ting Li, Zhi‐hong Feng, Que Bai, Jia‐xin Hao, Xiao‐qing Cao, Tao Ye, Jing Li, Franklin R. Tay, Malcolm Xing, Ming Fang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Determinants of cancer mortality in patients after acute myocardial infarction. [PDF]

Int J Cardiol Heart Vasc
Scharlach D, Schmitz T, Raake P, Linseisen J, Meisinger C.   +4 more
europepmc   +1 more source

Translational immunothrombosis in autoimmune Heparin-Induced thrombocytopenia: targeting the FcγRIIa-Syk-BTK and complement pathways. [PDF]

Clin Exp Med
Ahmadinia M, Askarzade A, Afsharara H, Gholizadeh Niari B, Jamali F, Farasatinasab M.   +5 more
europepmc   +1 more source

Aβ₁₋₄₀ Enhances Platelet Sensitivity to Thrombin via NADPH Oxidase-ROS Signaling and Integrin α_IIbβ_₃ Engagement. [PDF]

Biomol Ther (Seoul)
Kim B, Lee BK, Kim JA, Jung YS.
europepmc   +1 more source

Costunolide, a Sesquiterpene Lactone, Protects Against Platelet Activation and Thrombus Formation. [PDF]

Cells
Sheu JR, Lin KH, Chen RJ, Chia HP, Chen TY, Jayakumar T, Wang HH, Peng HY, Li JY, Lu WJ.   +9 more
europepmc   +1 more source

Platelet-mediated progression of fatty liver disease in metabolic dysfunction-associated steatohepatitis: a pathophysiological review. [PDF]

Front Med (Lausanne)
Alhawiti NM.
europepmc   +1 more source

Repurposing piroxicam for antithrombotic and cardiopulmonary protection: Pharmacological rationale and therapeutic potential.

Indian J Pharmacol
Khalid W, Khan AU.
europepmc   +1 more source