Results 261 to 270 of about 54,964 (304)

Inhibitors of “spontaneous” platelet aggregation in whole blood

Atherosclerosis, 1985
In vitro 'spontaneous' platelet aggregation has been studied in whole blood. The spectrum of activity of materials known to influence platelet aggregation in platelet-rich plasma proved different in whole blood. Thus dipyridamole and one of its analogues SH1242 had a striking effect in whole blood whilst aspirin, chlorpromazine and K3920 had little or ...
M J, Harrison, S S, Pollock, M, Steiner, E, Weisblatt   +3 more
openaire   +2 more sources

New pyridazinone derivatives as inhibitors of platelet aggregation

European Journal of Medicinal Chemistry, 1995
Summary The synthesis and evaluation of the biological activity of a series of 3(2 H )-pyridazinone derivatives is reported. We assessed the in vitro activity of these compounds on aggregation and production of thromboxane A 2 and prostaglandin E 2 of human platelets.
S. Corsano, R. Vezza, R. Scapicchi, S. Foresi, G. Strappaghetti, NENCI, Giuseppe Giorgio, GRESELE, Paolo   +6 more
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In Vitro Evaluation of Inhibitors of Platelet Release and Aggregation

Archives of Surgery, 1975
In order to determine which drugs would be most effective as inhibitors of platelet release and aggregation, in vitro release reactions and platelet aggregometry were used to evaluate aspirin, dipyridamole, sulfinpyrazone, flurbiprofen, low molecular weight dextran (dextran 40), prostaglandin E1 (PGE1), apyrase, and adenosine.
J C, Rosenberg, T L, Sell
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Lebetin Peptides: Potent Platelet Aggregation Inhibitors

Pathophysiology of Haemostasis and Thrombosis, 2001
Lebetins from <i>Macrovipera lebetina</i> snake venom constitute a new class of inhibitors of platelet aggregation. There are two groups of peptides: lebetin 1 (L1; 11- to 13-mer) and lebetin 2 (L2; 37- to 38-mer). The short lebetins are identical to the N-terminal segments of the longer ones.
N, Marrakchi, K, Mabrouk, I, Regaya, S, Sarray, M, Fathallah, H, Rochat, M, El Ayeb   +6 more
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Bleeding in a Patient Receiving Platelet Aggregation Inhibitors

Anesthesia & Analgesia, 2001
We describe a patient who experienced intraoperative bleeding after being treated with platelet receptor glycoprotein IIb/IIIa antagonist eptifibatide. We used Sonoclot and Thrombelastograph to monitor antiplatelet effects of eptifibatide.
J H, Waters, D G, Anthony, A, Gottlieb, J, Sprung   +3 more
openaire   +2 more sources

Platelet turnover in metastatic cancer and the effect of platelet aggregation inhibitors

Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1976
Patients with metastatic cancer have a permanent shortening of platelet survival and increased platelet consumption. Acetylsalicylic acid or dipyridamole in doses known to inhibit platelet aggregation, had no effect on platelet consumption.
openaire   +2 more sources

New carbamoylpiperidines as human platelet aggregation inhibitors

Bioorganic & Medicinal Chemistry, 2000
A series of 3-carbamoylpiperidines (nipecotamides) are designed, synthesized and tested for their inhibitory action against adenosine diphosphate (ADP)-induced aggregation of human platelets. A structure-activity analysis of the bis(nipecotamido)aralkane type showed that a substituent on the piperidine ring should preferably be an amide and that the ...
Z, Guo, X, Zheng, W, Thompson, M, Dugdale, R, Gollamudi   +4 more
openaire   +2 more sources

Cardamom extract as inhibitor of human platelet aggregation

Phytotherapy Research, 2005
The inhibitory activity of cardamom extract was studied on human platelets. Platelet aggregation and lipid peroxidation were evaluated with platelet rich plasma (PRP) and platelet membranes, respectively, obtained from blood of healthy volunteers.
W Jessie, Suneetha, T P, Krishnakantha
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A Circulating Inhibitor of Platelet Aggregation in Bartter's Syndrome

Pediatrics, 1979
Aggregation studies were performed on platelets from five patients with Bartter's syndrome. Epinephrine failed to induce aggregation in all five patients. Adenosine 5'-diphosphate (ADP) produced a single reversible phase of aggregation, and there was depressed sensitivity to collagen. Response to ristocetin was normal.
S O, O'Reagan, G E, Rivard, J G, Mongeau, P O, Robitaille   +3 more
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Enantioselective Synthesis of Imperanene, a Platelet Aggregation Inhibitor

Organic Letters, 2001
Both enantiomers of imperanene, a platelet aggregation inhibitor, have been synthesized in 82-90% ee. The key step of establishing the chiral center was achieved through stereoselective alkylation with benzyl chloromethyl ether using Enders' RAMP/SAMP chiral auxiliary method.
J C, Shattuck, C M, Shreve, S E, Solomon
openaire   +2 more sources