Results 21 to 30 of about 74,252 (240)
Shear-Induced Unfolding Activates von Willebrand Factor A2 Domain for Proteolysis [PDF]
J. Thromb. Haemost. 2009 (7), 2096-2105, 2009 To avoid pathological platelet aggregation by von Willebrand factor (VWF), VWF multimers are regulated in size and reactivity for adhesion by ADAMTS13-mediated proteolysis in a shear flow dependent manner. We examined if tensile stress in VWF under shear flow activates the VWF A2 domain for cleavage by ADAMTS13 using molecular dynamics simulations.
arxiv +1 more source
Redox Biology, 2022 Protein disulfide isomerase (PDI), an oxidoreductase, possesses two vicinal cysteines in the -Cys-Gly-His-Cys-motif that either form a disulfide bridge (S–S) or exist in a sulfhydryl form (-SH), forming oxidized or reduced PDI, respectively. PDI has been
Lu Wang +6 more
doaj
Thrombosis Journal, 2012 The clinical use of Sodium nitroprusside (SNP) may be associated with an alteration of platelet function. The main focus of this study was the effect of SNP on platelet aggregation in the absence or presence of endothelial cells.
Topf Hans-Georg +4 more
doaj +1 more source
Aggregation of human platelets by Tannerella Forsythia
Contemporary Clinical Dentistry, 2022 Context: Periodontitis is a persistent infection of the tissues surrounding the teeth characterized by inflamed microvasculature, and is associated with increased systemic platelet activation.
Eugene J Whitaker +2 more
doaj +1 more source
Вісник проблем біології і медицини, 2019 In order to establish signaling mechanisms of platelet dysfunction among patients with acute gastroduodenal ulcer bleeding the assessment of agonist-induced platelet aggregation was performed by means of the spectrophotometric method and inhibitory ...
Delii V. Yu., Sulaieva O. M.
doaj +1 more source
Platelets, 2021 )Several earlier studies have reported increased risk of bleeding in women with myocardial infarction, (MI) compared to men. The reasons for the observed difference are incompletely understood, but one suggested explanation has been excess dosing of ...
Anna Holm +7 more
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Three-dimensional Multiscale Model of Deformable Platelets Adhesion to Vessel Wall in Blood Flow [PDF]
, 2013 When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering and rolling on the injured endothelium is a critical initial step in blood clot formation.
arxiv +1 more source
Aging of the Nonlinear Optical Susceptibility of colloidal solutions [PDF]
Phys. Rev. B 75, 224203 (2007), 2006 Using Z-scan and dynamic light scattering measurements we investigate the nonlinear optics response of a colloidal solution undergoing dynamics slowing down with age. We study the high optical nonlinearity of an organic dye (Rhodamine B) dispersed in a water-clay (Laponite) solution, at different clay concentrations (2.0 wt% - 2.6 wt%), experiencing ...
arxiv +1 more source
A continuum model for the unfolding of von Willebrand Factor [PDF]
, 2021 von Willebrand Factor is a mechano-sensitive protein circulating in blood that mediates platelet adhesion to subendothelial collagen and platelet aggregation at high shear rates. Its hemostatic function and thrombogenic effect, as well as susceptibility to enzymatic cleavage, are regulated by a conformational change from a collapsed globular state to a
arxiv +1 more source
Factor Xa Inhibitor Suppresses the Release of Phosphorylated HSP27 from Collagen-Stimulated Human Platelets: Inhibition of HSP27 Phosphorylation via p44/p42 MAP Kinase. [PDF]
PLoS ONE, 2016 Selective inhibitors of factor Xa (FXa) are widely recognized as useful therapeutic tools for stroke prevention in non-valvular atrial fibrillation or venous thrombosis.
Masanori Tsujimoto +10 more
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