Results 21 to 30 of about 237,328 (413)

clotFoam: An Open-Source Framework to Simulate Blood Clot Formation Under Arterial Flow [PDF]

SoftwareX (2023) 101483, 2023
Blood clotting involves the coupled processes of platelet aggregation and coagulation. Simulating clotting under flow in complex geometries is challenging due to multiple temporal and spatial scales and high computational cost. clotFoam is an open-source software developed in OpenFOAM that employs a continuum model of platelet advection, diffusion, and
arxiv   +1 more source

Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]

, 2020
Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B., Lakshminarayanan, Karthik, Layfield, Harry J., Mehmi, Amita, Patel, Ketan, Ravishankar, Divyashree, Salim, Anika, Sonavane, Medha, Trim, Steven A., Vaiyapuri, Rajendran, Vaiyapuri, Sakthivel, Vallance, Thomas M., Williams, Harry F.   +12 more
core   +1 more source

Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

Nature Communications, 2020
Current inhibitors of platelet integrin αIIbβ3 cause excessive bleeding, which limited their clinical use in cardiac patients. Here the authors design pure orthosteric αIIbβ3 inhibitors that prevent platelet aggregation and thrombosis without causing ...
Brian D. Adair, José L. Alonso, Johannes van Agthoven, Vincent Hayes, Hyun Sook Ahn, I-Shing Yu, Shu-Wha Lin, Jian-Ping Xiong, Mortimer Poncz, M. Amin Arnaout   +9 more
doaj   +1 more source

Mechanobiology of shear-induced platelet aggregation leading to occlusive arterial thrombosis: a multiscale in silico analysis [PDF]

, 2021
Occlusive thrombosis in arteries causes heart attacks and strokes. The rapid growth of thrombus at elevated shear rates (~10,000 1/s) relies on shear-induced platelet aggregation (SIPA) thought to come about from the entanglement of von Willebrand factor (VWF) molecules.
arxiv   +1 more source

Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics [PDF]

, 2017
Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial cells (ECs), thrombin dynamically regulates
Hoogendijk, Arie J., Meijer, Alexander B., Mertens, Koen, Simpson, Pelle J., van Alphen, Floris P.J., van den Biggelaar, Maartje, van den Eshof, Bart L., Zanivan, Sara   +7 more
core   +7 more sources

Influence of Platelet Aggregation Modulators on Cyclic AMP Production in Human Thrombocytes

Folia Medica, 2018
Background: Cyclic AMP is a powerful inhibitor of platelet aggregation. In the present study we examined the effect of platelet aggregation modulators on cyclic AMP content in human thrombocytes.
Boyanov Krasimir O., Maneva Ana I.
doaj   +1 more source

Glycoprotein Ib activation by thrombin stimulates the energy metabolism in human platelets [PDF]

, 2017
Thrombin-induced platelet activation requires substantial amounts of ATP. However, the specific contribution of each ATP-generating pathway i.e., oxidative phosphorylation (OxPhos) versus glycolysis and the biochemical mechanisms involved in the thrombin-
A Archiche, A Ferreta, A Kasirer-Friede, A Lechi, A Marín-Hernández, AI Schafer, AJM Verhoeven, AM Amorini, AN Sveshnikova, AR Gear, Christian Schulz, D Banerjee, DA Slatter, E De Candia, E De Candia, F Adam, F Sinigaglia, G Solsau, GN Bijur, H Kilkson, HU Bergmeyer, I Fisher, I Hernández-Reséndiz, Ileana Hernández-Reséndiz, J Deprez, JRS Day, JW Akkerman, JY Jang, KS Authi, L Brass, LR Sorbara, M Baggiolini, Manuel Gutiérrez-Aguilar, MH Rider, MR Wardell, MY Shen, N Cardenes, N Corona de la Peña, NM Bressler, Norma Corona de la Peña, RA Nakashima, RL Elstrom, RM Denton, RW Moreadith, S Kim, S Offermans, S Ravi, S Rodríguez-Enríquez, S Zharikov, Sara Rodríguez-Enríquez, SI Obydennyy, T Sabo, V Vasta, Y Dobrydneva, Y Dobrydneva, ZP Shaik, Álvaro Marín-Hernández   +56 more
core   +4 more sources

An Aorta Intima Inhibitor of Platelet Aggregation [PDF]

Thrombosis and Haemostasis, 1977
The interaction of platelets and the vessel wall is of importance in the pathogenesis of intravascular thrombosis and atherosclerosis. We have previously described the presence of an inhibitor of platelet aggregation and a low Km ADPase in aorta intima extracts.
A. duP. Heyns, C. J. Badenhorst, Francois P. Retief   +2 more
openaire   +1 more source

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3 [PDF]

, 2016
Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human ...
Arman, Mònica, Cox, Dermot, Henderson, Ian R., Kerrigan, Steven W., Watson, Callum N., Watson, Steve P.   +5 more
core   +3 more sources

Comparison of the GPVI inhibitors losartan and honokiol

Platelets, 2020
Losartan and honokiol are small molecules which have been described to inhibit aggregation of platelets by collagen. Losartan has been proposed to block clustering of GPVI but not to affect binding of collagen. Honokiol has been reported to bind directly
Marie-Blanche Onselaer, Magdolna Nagy, Chiara Pallini, Jeremy A Pike, Gina Perrella, Lourdes Garcia Quintanilla, Johannes A Eble, Natalie S. Poulter, Johan W.M. Heemskerk, Steve P Watson   +9 more
doaj   +1 more source