Kinetics of Free Platelet Decrease After ADP: Effect of Fibrinogen Binding Inhibitors [PDF]
, 1995 Evaluation of platelet aggregation in vitro has generally been performed by the turbidometric method. This technique is largely insensitive to early events of aggregation which, are best evaluated by following the decrease in number of free-platelets ...
Rocca, Bianca
core +1 more source
Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]
, 2005 Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Siedler, F. +3 more
core +1 more source
Pharmacological Effect of Nitroprusside on Platelet Aggregation [PDF]
, 2023 Adequate platelet function and numbers are critical for postcardiopulmonary bypass patients. Endogenous and pharmacological sources of nitric oxide (NO) are known inhibitors of platelet aggregation.
Pamela R. Parrish, Douglas F. Larson
core +1 more source
Thrombosis Is Reduced by Inhibition of COX-1, but Unaffected by Inhibition of COX-2, in an Acute Model of Platelet Activation in the Mouse [PDF]
, 2011 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Zain, ZN +16 more
core +1 more source
COX-1 INHIBITORS AS ANTI-PLATELET AGENTS IN COVID-19 [PDF]
, 2022 Coronavirus Disease 19 (COVID-19) is primarily a lung disease which frequently leads to major cardiovascular complications and a poor prognosis due to excessive platelet activation, uncontrolled immune/inflammatory reactions ("cytokine storm ...
Solidoro, R. +5 more
core
2,3-Diphosphoglycerate: A Physiological Inhibitor of Platelet Aggregation
Science, 1975 2,3-Diphosphoglycerate (2,3-DPG) may inhibit the platelet release reaction and the irreversible aggregation of human blood platelets induced by adenosine diphosphate, epinephrine, or norepinephrine. The effects of 2,3-DPG on platelet aggregation were more pronounced in cases with low hematocrit (< 30 percent).
IATRIDIS, SG +3 more
openaire +3 more sources
Exogenous Inhibitors of Platelet Aggregation from Animal Sources [PDF]
, 2001 SummaryThis updated inventory includes all inhibitors of platelet aggregation from animal sources until mid-1999. They are proteins or glycoproteins with Mr from 5000 to tens of thousands, and inhibit platelet aggregation by different mechanisms.
Geraldine Chow, R. Manjunatha Kini
core +1 more source
Cyclooxygenase-2 Inhibitors Enhance Shear Stress-Induced Platelet Aggregation [PDF]
, 2006 ObjectivesWe aimed to investigate the effect of parecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on in vivo shear stress-induced platelet aggregation in a rat model of arterial bypass with focal narrowing.BackgroundLong-term use of COX-2 ...
Paulus, Walter J. +2 more
core +1 more source
Elderly patients are hyperresponsive to potent P2Y12 inhibitors
Research and Practice in Thrombosis and HaemostasisBackground: Aging has recently been associated with increased basal platelet activation and platelet hyperreactivity in response to adenosine diphosphate (ADP) but with decreased platelet response to thrombin receptor stimulation in individuals without ...
David Mutschlechner +7 more
doaj +1 more source
Platelets, 2021 )Several earlier studies have reported increased risk of bleeding in women with myocardial infarction, (MI) compared to men. The reasons for the observed difference are incompletely understood, but one suggested explanation has been excess dosing of ...
Anna Holm +7 more
doaj +1 more source