Results 21 to 30 of about 54,964 (304)

The effect of P2Y12 inhibition on platelet activation assessed with aggregation- and flow cytometry-based assays

Platelets, 2017
Patients on P2Y12 inhibitors may still develop thrombosis or bleeding complications. Tailored antiplatelet therapy, based on platelet reactivity testing, might reduce these complications.
Tesse C. Leunissen, Peter Paul Wisman, Thijs C. van Holten, Philip G. de Groot, Suzanne J. Korporaal, Arnold C. Koekman, Frans L. Moll, Martin Teraa, Marianne C. Verhaar, Gert Jan de Borst, Rolf T. Urbanus, Mark Roest   +11 more
doaj   +1 more source

Platelet Activation and Aggregation Induced by Streptococcus bovis/Streptococcus equinus Complex

Microbiology Spectrum, 2022
Streptococcus bovis/Streptococcus equinus complex (SBSEC) is a common cause of infective endocarditis (IE). For IE-pathogens, the capacity to activate and aggregate platelets is believed to be an important virulence mechanism.
Gustav Pernow, Oonagh Shannon, Jonas Öberg, Bo Nilson, Magnus Rasmussen   +4 more
doaj   +1 more source

Aggregation of human platelets by Tannerella Forsythia

Contemporary Clinical Dentistry, 2022
Context: Periodontitis is a persistent infection of the tissues surrounding the teeth characterized by inflamed microvasculature, and is associated with increased systemic platelet activation.
Eugene J Whitaker, Caitlin D Darcey, Susan M Somerset   +2 more
doaj   +1 more source

Investigating small-molecule inhibitors of platelet aggregation [PDF]

, 2023
Cardiovascular disease, including myocardial infarction, remains the number one cause of worldwide morbidity and mortality. The major cause of myocardial infarction is arterial thrombosis, driven by platelet aggregation.

core   +2 more sources

Purification and characterization of platelet aggregation inhibitor from the Gloydius blomhoffii brevicaudus venom

Біологічні студії, 2012
Gloydius venom is a rich natural source of proteins possessing platelet aggregation inhibition activity. These proteins or their recombinant analogs are universal instruments for the investigation of proteins and receptors interaction in hemostatic ...
A. I. Zhukova, G. L. Volkov
doaj   +1 more source

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (Coffea arabica)

Molecules, 2020
Coffee is rich in caffeine (CF), chlorogenic acid (CGA) and phenolics. Differing types of coffee beverages and brewing procedures may result in differences in total phenolic contents (TPC) and biological activities. Inflammation and increases of platelet
Nuntouchaporn Hutachok, Pongsak Angkasith, Chaiwat Chumpun, Suthat Fucharoen, Ian J. Mackie, John B. Porter, Somdet Srichairatanakool   +6 more
doaj   +1 more source

Drug interactions and hepatotoxicity of clopidogrel [PDF]

, 2010
Clopidogrel (Plavix¨) is an antiplatelet drug, which is clinically used in combination with aspirin to reduce cardiovascular events in patients undergoing percutaneous coronary intervention or in patients suffering from acute coronary syndromes ...
Zahno, Anja-Christina
core   +1 more source

Platelet Glycoprotein IIb/IIIa Inhibitors Effects Beyond the Platelet [PDF]

Adjunctive blockade of platelet glycoprotein (GP) IIb/IIIa during percutaneous coronary intervention (PCI) or in patients who present with acute coronary syndromes has been effective in reducing platelet-mediated adverse ischemic clinical outcomes (1–6).
Kereiakes, Dean J, Goldschmidt-Clermont, Pascal J   +1 more
core   +3 more sources

Metabolic plasticity in resting and thrombin activated platelets.

PLoS ONE, 2015
Platelet thrombus formation includes several integrated processes involving aggregation, secretion of granules, release of arachidonic acid and clot retraction, but it is not clear which metabolic fuels are required to support these events.
Saranya Ravi, Balu Chacko, Hirotaka Sawada, Philip A Kramer, Michelle S Johnson, Gloria A Benavides, Valerie O'Donnell, Marisa B Marques, Victor M Darley-Usmar   +8 more
doaj   +1 more source

Endothelial cells influence the sodium nitroprusside mediated inhibition of platelet aggregation by an as yet unkown pathway

Thrombosis Journal, 2012
The clinical use of Sodium nitroprusside (SNP) may be associated with an alteration of platelet function. The main focus of this study was the effect of SNP on platelet aggregation in the absence or presence of endothelial cells.
Topf Hans-Georg, Rauh Manfred, Rascher Wolfgang, Dötsch Jörg, Klinge Jens M   +4 more
doaj   +1 more source