Results 1 to 10 of about 1,933,674 (88)
Platelets, 2020 Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder in which autoantibodies and/or autoreactive T cells destroy platelets and megakaryocytes in the spleen and bone marrow, respectively.
R. Kapur +4 more
semanticscholar +1 more source
Anti‐platelet antibody immunoassays in childhood immune thrombocytopenia: a systematic review
Vox Sanguinis, 2020 In adult immune thrombocytopenia (ITP), an acquired autoimmune bleeding disorder, anti‐platelet autoantibody testing may be useful as a rule‐in test. Childhood ITP has different disease characteristics, and the diagnostic and prognostic value of anti ...
D. Schmidt +6 more
semanticscholar +1 more source
Platelet-collagen adhesion: evidence for participation of antigenically distinct entities. [PDF]
, 1984 Univalent antibody fragments prepared from a rabbit antiserum raised against whole human platelets completely inhibited adhesion of platelets to immobilized trimeric collagen in a defined, Mg2+-dependent, adhesion assay.
Barondes, SH, Shadle, PJ
core +2 more sources
Internal medicine, 2016 Vancomycin-induced thrombocytopenia is a rare adverse reaction that may be overlooked because no specific diagnostic test is currently available.
J. Yamanouchi +5 more
semanticscholar +1 more source
Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation [PDF]
, 2008 The activation of initiator protein tissue factor (TF) is likely to be a crucial step in the blood coagulation process, which leads to fibrin formation. The stimuli responsible for inducing TF activation are largely undefined.
Altmann, Berid +13 more
core +3 more sources
New England Journal of Medicine, 1994 BACKGROUND Platelets are believed to play a part in the ischemic complications of coronary angioplasty, such as abrupt closure of the coronary vessel during or soon after the procedure.
Epic Investigators
semanticscholar +1 more source
Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-antibodies [PDF]
, 2016 Mechanisms leading to decreased platelet count in immune thrombocytopenia (ITP) are heterogeneous. This study describes increased platelet apoptosis involving loss of mitochondrial membrane potential (ΔΨm), caspase 3 activation (aCasp3) and ...
Contrufo, Geraldine +11 more
core +1 more source
Revista Brasileira de Hematologia e Hemoterapia, 2013 Background Immune platelet refractoriness is mainly caused by human leukocyte antigen antibodies (80-90% of cases) and, to a lesser extent, by human platelet antigen antibodies.
C. Bub +5 more
semanticscholar +1 more source
Intraoperative blood transfusions in highly alloimmunized patients undergoing orthotopic liver transplantation. [PDF]
, 1989 Intraoperative blood requirements were analyzed in patients undergoing primary orthotopic liver transplantation and divided into two groups on the basis of panel reactive antibody of pretransplant serum measured by lymphocytotoxicity testing.
Duquesnoy, RJ +5 more
core +1 more source
Syk-dependent Phosphorylation of CLEC-2: A Novel Mechanism of Hem-Immunoreceptor Tyrosine-Based Activation Motif Signaling [PDF]
, 2010 The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM).
Eble, J. A. +7 more
core +2 more sources