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Determination of Antibody Activity by Platelet Aggregation [PDF]
Bio-Protocol, 2023 Platelets play an important role in hemostasis by forming clots and stopping bleeding. In immune thrombotic conditions, platelets and leukocytes are aberrantly activated by pathogenic antibodies resulting in platelet aggregates and NETosis, leading to ...
Halina Leung +3 more
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Molecules, 2020 Thrombopoietin (THPO) is a circulatory cytokine that plays an important role in platelet production. The presence of anti-THPO antibody relates to thrombocytopenia and is rarely seen in hematopoietic and autoimmune diseases.
Takuya Fukuda +11 more
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Platelet antibody screening and analysis of influencing factors [PDF]
Xin yixueObjective To analyze the positive rate distribution of platelet antibodies in different types of patients and different diseases by screening platelet antibodies in 27， 239 emergent and hospitalized patients， aiming to explore the influencing factors of ...
LAI Peibin, XU Lijuan, CEN Zhihua, ZHAO Caihan, LU Ying, ZOU Yong
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Platelet antibodies in immune thrombocytopenia and related conditions
Journal of Laboratory Medicine, 2020 Platelet autoantibodies are a common finding in immune thrombocytopenia (ITP) and in rare cases of antibody-mediated platelet function (“acquired thrombasthenia”).
Kiefel Volker
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Zhongguo shuxue zazhi, 2022 Objective To investigate the factors influencing the production of platelet antibody and its effect on clinical platelet transfusion. Methods This is a single-center prospective observational study.
Qianwen SHANG +4 more
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Unappreciated HLA Antibodies in Adult Immune Thrombocytopenic Purpura
Journal of the Formosan Medical Association, 2007 Immune thrombocytopenic purpura (ITP) is an autoimmune disease. Platelet refractoriness is frequently seen in patients with ITP. Platelets express platelet-specific antigens and human leukocyte antigens (HLA).
Jeong-Shi Lin +7 more
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A megakaryocyte with no platelets: Anti-platelet antibodies, apoptosis, and platelet production
Platelets, 2012 Primary immune thrombocytopenia (ITP) and drug-induced thrombocytopenia (DITP) are disorders caused primarily by the presence of anti-platelet auto-antibodies (Abs). Hematologists have traditionally seen thrombocytopenia as the result of increased destruction of Ab-coated platelets by the reticuloendothelial system.
José, Perdomo, Feng, Yan, Beng H, Chong
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Antibodies to platelets in patients with anti-phospholipid antibodies [PDF]
Blood, 1991 Binding of anti-phospholipid antibodies to circulating platelets and its consequences on platelet activation and aggregation was investigated in 11 patients with anti-phospholipid antibodies. Seven patients had mild thrombocytopenia. Nine healthy donors served as controls. Binding to platelets was investigated by performing enzyme- linked immunosorbent
H J, Out +5 more
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Platelet antibodies identification: comparison between two laboratory tests
Hematology, Transfusion and Cell Therapy, 2022 Introduction: Platelet antibody identification is indispensable for diagnosing the human platelet antigen (HPA) or human leukocyte antigen (HLA) immunization, mostly because it can restrict the compatibility and results of transfusions. Correct detection
Valeria de Freitas Dutra +6 more
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Correlation between serum HLA and HPA antibody strength and transfusion effect in patients with ineffective immune platelet transfusion [PDF]
Jichu yixue yu linchuangObjective To exploring the clinical significance of changes in human leukocyte antigen (HLA) and human platelet antigen (HPA) antibodies in the serum of patients with ineffective immune platelet transfusion, and to analyze the effects of antibody ...
ZHU Wenjuan, CUI Fan
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