Results 11 to 20 of about 2,173,038 (398)

Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia

Haematologica, 2022
Immune thrombocytopenia (ITP) is a bleeding disorder caused by dysregulated B- and T- cell functions, which lead to platelet destruction. A well-recognized mechanism of ITP pathogenesis involves anti-platelet and anti-megakaryocyte antibodies recognizing
S. Zheng, Z. Ahmadi, H. Leung, R. Wong, Feng Yan, J. Perdomo, B. Chong   +6 more
semanticscholar   +1 more source

Application of flow cytometry in transfusion medicine: The Sanjay Gandhi Post Graduate Institute of Medical Sciences, India experience

Asian Journal of Transfusion Science, 2022
The application of flow cytometry (FC) is diverse and this powerful tool in used in multiple disciplines such as molecular biology, immunology, cancer biology, virology, and infectious disease screening.
Rajendra Chaudhary, Sudipta Sekhar Das
doaj   +1 more source

Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP)

Platelets, 2020
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder in which autoantibodies and/or autoreactive T cells destroy platelets and megakaryocytes in the spleen and bone marrow, respectively.
R. Kapur, Rukhsana Aslam, E. Speck, Johan Rebetz, J. Semple   +4 more
semanticscholar   +1 more source

Maternal alloimmune antibodies against HPA and HLA class I antigens are associated with reduced birthweight among healthy neonates delivered by Chinese women

Acta Obstetricia et Gynecologica Scandinavica, 2022
Introduction It is well known that HPA‐1a antibodies lead to fetal and neonatal alloimmune thrombocytopenia (FNAIT), and an association with reduced birthweight in boys has been reported. Although it remains unclear whether HLA antibodies cause FNAIT, an
Yang Xue, Wenlong Xin, Chao Li, Xing Zeng, Zhanyun Song, Chen Cao, Tongmao Zhao   +6 more
doaj   +1 more source

The association between platelet glycoprotein-specific antibodies and response to short-term high-dose dexamethasone with prednisone maintenance treatment in adult patients with primary immune thrombocytopenia

Annals of Medicine, 2022
Objective The aim of the present study was to detect the association between platelet glycoprotein-specific autoantibodies and the patient response to short-term high-dose dexamethasone (HD-DXM) + prednisone maintenance treatment.
Yan-Qiu Hou, Yan Wang, Chang-Xun Liu, Shu-Xia Li, Ya-Lan Peng, Wang Dong-Dong, Ru-La Sa   +6 more
doaj   +1 more source

A Pilot Study on the Effect of Anti-Thrombopoietin Antibody on Platelet Count in Patients with Type 2 Diabetes

Molecules, 2020
Thrombopoietin (THPO) is a circulatory cytokine that plays an important role in platelet production. The presence of anti-THPO antibody relates to thrombocytopenia and is rarely seen in hematopoietic and autoimmune diseases.
Takuya Fukuda, Masahide Hamaguchi, Takafumi Osaka, Yoshitaka Hashimoto, Emi Ushigome, Mai Asano, Masahiro Yamazaki, Eriko Fukuda, Kei Yamaguchi, Koji Ogawa, Naoki Goshima, Michiaki Fukui   +11 more
doaj   +1 more source

Detection of platelet antibody and evaluation of platelet transfusion efficacy in patients with hematologic disease

Zhongguo shuxue zazhi, 2022
Objective To investigate the factors influencing the production of platelet antibody and its effect on clinical platelet transfusion. Methods This is a single-center prospective observational study.
Qianwen SHANG, Bin TAN, Zhuoyue PENG, Li WANG, Li QIN   +4 more
doaj   +1 more source

Transfusion effect of 0.5-dose of apheresis platelet in pediatric patients

Zhongguo shuxue zazhi, 2023
Objective To investigate the transfusion effect of 0.5-dose of apheresis platelet in pediatric patients. Methods A total of 195 children who underwent 0.5-dose platelet transfusion from August 2021 to June 2022 were enrolled, and the platelet count ...
Lijuan QIU, Zida ZHEN, Xiaoyan FU, Shuxuan MA   +3 more
doaj   +1 more source

Platelet-collagen adhesion: evidence for participation of antigenically distinct entities. [PDF]

, 1984
Univalent antibody fragments prepared from a rabbit antiserum raised against whole human platelets completely inhibited adhesion of platelets to immobilized trimeric collagen in a defined, Mg2+-dependent, adhesion assay.
Barondes, SH, Shadle, PJ
core   +2 more sources

Platelet antibody screening and analysis of influencing factors [PDF]

Xin yixue
Objective To analyze the positive rate distribution of platelet antibodies in different types of patients and different diseases by screening platelet antibodies in 27， 239 emergent and hospitalized patients， aiming to explore the influencing factors of ...
LAI Peibin, XU Lijuan, CEN Zhihua, ZHAO Caihan, LU Ying, ZOU Yong
doaj   +1 more source