Results 11 to 20 of about 175,124 (315)
Molecules, 2020 Thrombopoietin (THPO) is a circulatory cytokine that plays an important role in platelet production. The presence of anti-THPO antibody relates to thrombocytopenia and is rarely seen in hematopoietic and autoimmune diseases.
Takuya Fukuda +11 more
doaj +1 more source
Zhongguo shuxue zazhi, 2022 Objective To investigate the factors influencing the production of platelet antibody and its effect on clinical platelet transfusion. Methods This is a single-center prospective observational study.
Qianwen SHANG +4 more
doaj +1 more source
Unappreciated HLA Antibodies in Adult Immune Thrombocytopenic Purpura
Journal of the Formosan Medical Association, 2007 Immune thrombocytopenic purpura (ITP) is an autoimmune disease. Platelet refractoriness is frequently seen in patients with ITP. Platelets express platelet-specific antigens and human leukocyte antigens (HLA).
Jeong-Shi Lin +7 more
doaj +1 more source
Antibodies to platelets in patients with anti-phospholipid antibodies [PDF]
Blood, 1991 Binding of anti-phospholipid antibodies to circulating platelets and its consequences on platelet activation and aggregation was investigated in 11 patients with anti-phospholipid antibodies. Seven patients had mild thrombocytopenia. Nine healthy donors served as controls. Binding to platelets was investigated by performing enzyme- linked immunosorbent
H. K. Nieuwenhuis +5 more
openaire +4 more sources
Platelet antibodies in immune thrombocytopenia and related conditions
Journal of Laboratory Medicine, 2020 Platelet autoantibodies are a common finding in immune thrombocytopenia (ITP) and in rare cases of antibody-mediated platelet function (“acquired thrombasthenia”).
Kiefel Volker
doaj +1 more source
Minimal Collagen-Binding Epitope of Glycoprotein VI in Human and Mouse Platelets
Biomedicines, 2023 Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin, regulating important platelet functions such as platelet adhesion and thrombus growth. Although the blockade of GPVI function is widely recognized as a potent anti-thrombotic
Chao Han +15 more
doaj +1 more source
Elimination of HLA antibodies by platelet adsorption [PDF]
Immunohematology, 2020 Abstract The presence of HLA antibodies in patient serum or plasma may make antibody identification difficult. These HLA antibodies may mask the presence of clinically significant red blood cell (RBC) alloantibodies. Because platelets strongly express HLA antigens, it is possible to remove HLA antibodies by adsorbing the patient’s serum ...
Jennifer Jung, Christina Barron
openaire +3 more sources
PLoS ONE, 2013 The platelet aggregation-inducing factor Aggrus, also known as podoplanin, is frequently upregulated in several types of tumors and enhances hematogenous metastasis by interacting with and activating the platelet receptor CLEC-2.
Satoshi Takagi +7 more
doaj +1 more source
Down-regulation of platelet surface CD47 expression in Escherichia coli O157:H7 infection-induced thrombocytopenia. [PDF]
PLoS ONE, 2009 BACKGROUND: Platelet depletion is a key feature of hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli (STEC) infection.
Ya-Lan Guo +4 more
doaj +1 more source
Effect of heterologous antibody on human platelets [PDF]
Blood, 1976 Abstract The effect of heterologous anti-human platelet antibody on human platelet function was examined in the presence and absence of whole plasma as an in vitro model for antibody-induced immune damage to cells. Heterologous IgG anti-human platelet antibody mediated platelet aggregation and released serotonin from both platelets in ...
Robert W. Colman, Alan D. Schreiber
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