Blood, 1969 Two technics have been developed, which make possible the in vitro detection of platelet antibody in patients with idiopathic thrombocytopenic purpura (ITP), and systemic lupus erythematosus (SLE).
S. Karpatkin, G. Siskind
semanticscholar +1 more source
Clinical Applications of Platelet Antibody and Antigen Testing
, 2011 Immune thrombocytopenia occurs when antibodies targeting specific glycoproteins (GPs) on the platelet surface lead to their destruction. Tests of the patient’s platelets and serum for antibodies and typing of DNA for human platelet alloantigens (HPA) can
Andrew J. Lochowicz, B. Curtis
semanticscholar +1 more source
A monoclonal anti-human platelet antibody: a new platelet aggregating substance.
Blood, 1985 A monoclonal anti-human platelet antibody, TP82, is described, which caused irreversible aggregation of platelets in association with the release of adenosine triphosphate or [14C] serotonin, and which inhibited ristocetin-induced agglutination ...
M. Higashihara +4 more
semanticscholar +1 more source
PLoS ONE, 2013 The platelet aggregation-inducing factor Aggrus, also known as podoplanin, is frequently upregulated in several types of tumors and enhances hematogenous metastasis by interacting with and activating the platelet receptor CLEC-2.
Satoshi Takagi +7 more
doaj +1 more source
Down-regulation of platelet surface CD47 expression in Escherichia coli O157:H7 infection-induced thrombocytopenia. [PDF]
PLoS ONE, 2009 BACKGROUND: Platelet depletion is a key feature of hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli (STEC) infection.
Ya-Lan Guo +4 more
doaj +1 more source
The adverse impact on liver transplantation of using positive cytotoxic crossmatch donors [PDF]
, 1992 Because of the liver graft's ability to resist cytotoxic antibody-mediated rejection, it has become dogma that the conventional transplant crossmatch used to avoid hyperacute rejection of other organs is irrelevant to the liver.
Abu-Elmagd, K +11 more
core +1 more source
The trans-sialidase from Trypanosoma cruzi induces thrombocytopenia during acute Chagas' disease by reducing the platelet sialic acid contents [PDF]
, 2005 Strong thrombocytopenia is observed during acute infection with Trypanosoma cruzi, the parasitic protozoan agent of American trypanosomiasis or Chagas' disease.
Campetella, O. +4 more
core +2 more sources
Amelioration of murine passive immune thrombocytopenia by IVIg and a therapeutic monoclonal CD44 antibody does not require the Myd88 signaling pathway. [PDF]
PLoS ONE, 2013 Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by a low platelet count and the production of anti-platelet antibodies. The majority of ITP patients have antibodies to platelet integrin α(IIb)β₃ (GPIIbIIIa) which can direct
Andrew R Crow +3 more
doaj +1 more source
Antibody Representation Learning for Drug Discovery [PDF]
arXiv, 2022 Therapeutic antibody development has become an increasingly popular approach for drug development. To date, antibody therapeutics are largely developed using large scale experimental screens of antibody libraries containing hundreds of millions of antibody sequences.
arxiv
Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production [PDF]
, 2017 The effect of lipopolysaccharide (LPS) on platelet aggregation is still controversial. We performed in vitro and ex vivo studies in controls and in patients with community-acquired pneumonia (CAP) to assess the effect of LPS on platelet activation (PA ...
Camilla Calvieri +9 more
core +1 more source