Results 41 to 50 of about 2,173,038 (398)

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]

, 2010
The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt, Atkinson, Barrow, Beata Grygielska, Bertrand Leblond, Bodin, Bodin, Boggon, Christou, Colonna, Eble, Ezumi, Fuller, He, Hooley, Hughes, Huysamen, Johannes A. Eble, Kerrigan, Laurent Désiré, Lee, Locke, May, McCarty, Pestina, Piechulek, Pierce, Pleines, Quek, Sancho, Schacht, Shutes, Simons, Sobanov, Spalton, Steve P. Watson, Suzuki-Inoue, Suzuki-Inoue, Tolias, Walliser, Watson, Watson, Wonerow, Wonerow, Xu   +44 more
core   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Down-regulation of platelet surface CD47 expression in Escherichia coli O157:H7 infection-induced thrombocytopenia. [PDF]

PLoS ONE, 2009
BACKGROUND: Platelet depletion is a key feature of hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli (STEC) infection.
Ya-Lan Guo, Dan-Qing Liu, Zhen Bian, Chen-Yu Zhang, Ke Zen   +4 more
doaj   +1 more source

A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. [PDF]

, 1985
We have previously characterized a monoclonal antibody, S12, that binds only to activated platelets (McEver, R.P., and M.N. Martin, 1984, J. Biol. Chem., 259:9799-9804). It identifies a platelet membrane protein of Mr 140,000, which we have designated as
Bainton, DF, Jacques, YV, McEver, RP, Shuman, MA, Stenberg, PE   +4 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Inflammation and Platelet Activation After COVID-19 Vaccines - Possible Mechanisms Behind Vaccine-Induced Immune Thrombocytopenia and Thrombosis

Frontiers in Immunology, 2021
Introduction of vaccines against COVID-19 has provided the most promising chance to control the world-wide COVID-19 pandemic. However, the adenovirus-vector based Oxford/AstraZeneca [ChAdOx1] (AZ) and Johnson & Johnson [Ad26.CoV2.S] COVID-19 vaccines ...
S. Ostrowski, O. Søgaard, M. Tolstrup, N. Stærke, J. Lundgren, L. Østergaard, A. Hvas   +6 more
semanticscholar   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Antibody identification and analysis of 80 children with positive platelet antibody in initial screening

Zhongguo shuxue zazhi
Objective To explore the distribution and types of platelet antibodies in children with positive platelet antibody in initial screening. Methods Blood samples of 80 pediatric patients who applied for platelet transfusion in our hospital from September ...
Xiaohuan WANG, Xiaoyan FU, Yu LIU, Shuaihang ZHANG, Shuxuan MA   +4 more
doaj   +1 more source

Amelioration of murine passive immune thrombocytopenia by IVIg and a therapeutic monoclonal CD44 antibody does not require the Myd88 signaling pathway. [PDF]

PLoS ONE, 2013
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by a low platelet count and the production of anti-platelet antibodies. The majority of ITP patients have antibodies to platelet integrin α(IIb)β₃ (GPIIbIIIa) which can direct
Andrew R Crow, Honghui Yu, Dongji Han, Alan H Lazarus   +3 more
doaj   +1 more source

Re-Evaluation Of Modified Rapid Monoclonal Antibody Immobilization Of Platelet Antigen (MR-MAIPA) For Detecting Platelet Antibody In Patients With Suspected Immune Thrombocytopenia [PDF]

, 2016
Ujian antibodi terhadap platelet di Malaysia hanya dijalankan di Pusat Darah Negara (PDN), Kuala Lumpur. Sebelum tahun 2013, ujian antibodi terhadap platelet di Malaysia dijalankan menggunakan teknik MAIPA. Namun begitu, MAIPA memerlukan masa selama tiga
Aziz, Mohd Fahmi
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