Results 41 to 50 of about 2,103,612 (328)

Detection and effects on platelet function of anti-platelet antibody in mule foals with experimentally induced neonatal alloimmune thrombocytopenia.

open access: yesJournal of Veterinary Internal Medicine, 1999
Horse mares carrying mule foals were immunized during the last trimester of pregnancy with whole acid-citrate-dextrose-anticoagulated donkey blood to experimentally induce neonatal alloimmune thrombocytopenia.
S. Ramirez   +3 more
semanticscholar   +1 more source

A monoclonal anti-platelet antibody with decreased reactivity for autoimmune thrombocytopenic platelets.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 1983
Two monoclonal anti-platelet antibodies, 3B2 and 8G11, have been raised that are specific for normal human platelets. 3B2 is unique in that it has decreased reactivity for platelets from 16 patients with autoimmune thrombocytopenic purpura [mean platelet
D. Varon, S. Karpatkin
semanticscholar   +1 more source

Combination peptide immunotherapy suppresses antibody and helper T-cell responses to the major human platelet autoantigen glycoprotein IIb/IIIa in HLA-transgenic mice

open access: yesHaematologica, 2019
Platelet destruction in immune thrombocytopenia is caused by autoreactive antibody and T-cell responses, most commonly directed against platelet glycoprotein IIb/IIIa.
Lindsay S. Hall   +5 more
doaj   +1 more source

When Two are Better than One: Modeling the Mechanisms of Antibody Mixtures [PDF]

open access: yes, 2019
It is difficult to predict how antibodies will behave when mixed together, even after each has been independently characterized. Here, we present a statistical mechanical model for the activity of antibody mixtures that accounts for whether pairs of antibodies bind to distinct or overlapping epitopes.
arxiv   +1 more source

Platelet antibody production in children with congenital heart disease leading to coagulation dysfunction and reduced platelet function

open access: yesZhongguo shuxue zazhi
[Objective] To analyze the production of platelet antibodies in children with congenital heart disease, identify the types of antibodies, and explore their effects on platelet count, coagulation function and platelet function.
ZHEN Zida   +4 more
doaj   +1 more source

High‐dose IVIG plus cangrelor platelet “anesthesia” during urgent heparin‐CPB in a patient with recent SRA‐negative HIT‐thrombosis with persisting platelet‐activating antibodies

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2020
In a high‐risk patient with subacute heparin‐induced thrombocytopenia (HIT) type A (platelet count recovery following acute HIT but with persisting platelet‐activating antibodies), in whom urgent cardiac surgery was required, a key clinical question ...
Andreas Koster   +5 more
doaj   +1 more source

In vivo evidence for platelet-induced physiological angiogenesis by a COX driven mechanism. [PDF]

open access: yesPLoS ONE, 2014
We sought to determine a role for platelets in in vivo angiogenesis, quantified by changes in the capillary to fibre ratio (C:F) of mouse skeletal muscle, utilising two distinct forms of capillary growth to identify differential effects.
Ian M Packham   +3 more
doaj   +1 more source

Three-dimensional Multiscale Model of Deformable Platelets Adhesion to Vessel Wall in Blood Flow [PDF]

open access: yes, 2013
When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering and rolling on the injured endothelium is a critical initial step in blood clot formation.
arxiv   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Re-Evaluation Of Modified Rapid Monoclonal Antibody Immobilization Of Platelet Antigen (MR-MAIPA) For Detecting Platelet Antibody In Patients With Suspected Immune Thrombocytopenia [PDF]

open access: yes, 2016
Ujian antibodi terhadap platelet di Malaysia hanya dijalankan di Pusat Darah Negara (PDN), Kuala Lumpur. Sebelum tahun 2013, ujian antibodi terhadap platelet di Malaysia dijalankan menggunakan teknik MAIPA. Namun begitu, MAIPA memerlukan masa selama tiga
Aziz, Mohd Fahmi
core  

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