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Platelets and platelet disorders in Africa
Baillière's Clinical Haematology, 1992Blood platelets, which are known to play important roles in normal vertebrate biology, are influenced by a variety of factors, the majority of which are acquired. In this chapter, attention is drawn to the need to re-examine one of the old accepted values in haematology, the normal platelet count.
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Platelet function disorders [PDF]
Haemophilia, 2000 Platelet function defects comprise a large and heterogeneous group of bleeding disorders that range in severity from mild to severe. Patients may be asymptomatic; however, the majority who are diagnosed present with easy bruising and mucocutaneous bleeding, or with excessive haemorrhage following injury or surgery.
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Blood Reviews, 1988
Congenital platelet disorders include thrombocytopathies and thrombocytopenias, which often occur in association. Thrombocytopathies constitute a model for exploring platelet physiology at the molecular level: adhesion, activation, release phenomena, aggregation.
J.P. Caen, S. Bellucci
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Congenital platelet disorders include thrombocytopathies and thrombocytopenias, which often occur in association. Thrombocytopathies constitute a model for exploring platelet physiology at the molecular level: adhesion, activation, release phenomena, aggregation.
J.P. Caen, S. Bellucci
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Quebec platelet disorder: update on pathogenesis, diagnosis, and treatment.
Seminars in Thrombosis and Hemostasis, 2011Quebec platelet disorder (QPD) is an autosomal dominant bleeding disorder associated with reduced platelet counts and a unique gain-of-function defect in fibrinolysis due to increased expression and storage of urokinase plasminogen activator (uPA) by ...
J. Blavignac +3 more
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The Lancet, 1981
The hypothesis that migraine is caused by a primary abnormality of platelet behaviour was investigated in a total of 77 migraine patients and control subjects. Platelets taken from patients with classical migraine during a headache-free period demonstrated significantly higher spontaneous platelet aggregation and platelet adhesion than platelets from ...
B. Wachowicz +3 more
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The hypothesis that migraine is caused by a primary abnormality of platelet behaviour was investigated in a total of 77 migraine patients and control subjects. Platelets taken from patients with classical migraine during a headache-free period demonstrated significantly higher spontaneous platelet aggregation and platelet adhesion than platelets from ...
B. Wachowicz +3 more
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Current Opinion in Hematology, 2003
Inherited platelet disorders are important causes of bleeding that can quantitatively and qualitatively alter platelets, impairing their function. The purpose of this review is to summarize current knowledge on the different types of inherited platelet disorders, their clinical and laboratory features, molecular genetic causes, and the therapies used ...
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Inherited platelet disorders are important causes of bleeding that can quantitatively and qualitatively alter platelets, impairing their function. The purpose of this review is to summarize current knowledge on the different types of inherited platelet disorders, their clinical and laboratory features, molecular genetic causes, and the therapies used ...
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2005
Publisher Summary Platelets are an important component in the first phase of hemostasis. This chapter gives a synoptic view of qualitative disorders of platelet function. When platelets are reduced in number, or become defective in function, bleeding may occur.
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Publisher Summary Platelets are an important component in the first phase of hemostasis. This chapter gives a synoptic view of qualitative disorders of platelet function. When platelets are reduced in number, or become defective in function, bleeding may occur.
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Thrombosis Research, 2016
In contrast to congenital platelet disorders, which are rare, acquired platelet dysfunctions are more common in clinical practice. Their main causes are medications and systemic/hematologic diseases. Typical clinical manifestations are mucosal bleeding, epistaxis, or superficial epidermal bleeding normally of modest entity. In most cases, the molecular
Caterina Casari, Wolfgang Bergmeier
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In contrast to congenital platelet disorders, which are rare, acquired platelet dysfunctions are more common in clinical practice. Their main causes are medications and systemic/hematologic diseases. Typical clinical manifestations are mucosal bleeding, epistaxis, or superficial epidermal bleeding normally of modest entity. In most cases, the molecular
Caterina Casari, Wolfgang Bergmeier
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Platelet Disorders in Pregnancy
Clinics in Perinatology, 1980This article focuses on the platelet component of hemostasis during pregnancy, and on abnormalities in coagulation attributable to a decrease in platelet number, qualitative platelet function, or both. The restrictions that pregnancy imposes on the evaluation and treatment of these hemostatic abnormalities are emphasized.
Roberto Romero, Thomas P. Duffy
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Platelet Disorders in Adolescents
Journal of Pediatric and Adolescent Gynecology, 2010Acquired and inherited platelet disorders can present with bleeding symptoms during adolescence. Platelet disorders include disorders of platelet number and disorders of platelet function. In adolescent females with platelet disorders, menorrhagia is a common presenting bleeding symptom.
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