Results 221 to 230 of about 2,127,148 (291)

Platelet factor 4(PF4) and its multiple roles in diseases.

Blood reviews, 2023
Platelet factor 4 (PF4) combines with heparin to form an antigen that could produce IgG antibodies and participate in heparin-induced thrombocytopenia (HIT).
Zhi-Yan Liu, Longtu Li, Han-Xu Zhang, Xiao-Cong Pang, Zhiwei Qiu, Q. Xiang, Yi-Min Cui   +6 more
semanticscholar   +1 more source

A radioimmunoassay for platelet factor 4

Thrombosis Research, 1976
Abstract A radioimmunoassay for the measurement of human platelet factor 4 is described which is sufficiently sensitive to measure the concentration of this protein in plasma. This assay can detect the release of platelet factor 4 from platelets in vitro .
A E, Bolton, C A, Ludlam, D S, Pepper, S, Moore, J D, Cash   +4 more
openaire   +2 more sources

Interaction of platelet factor 4 with human platelets

Biochimica et Biophysica Acta (BBA) - General Subjects, 1985
Human washed resting platelets bound 125I-labeled platelet factor 4 in a reaction which was saturable and approached equilibrium within 15-30 min. Scatchard plot analysis of the binding isotherms suggested a single class of specific binding sites. Excess of unlabeled protein and low- and high-affinity heparin competed for platelet factor 4 binding ...
A M, Capitanio, S, Niewiarowski, B, Rucinski, G P, Tuszynski, C S, Cierniewski, D, Hershock, E, Kornecki   +6 more
openaire   +2 more sources

Subcellular Localization of Platelet Factor 3 and Platelet Factor 4

Scandinavian Journal of Haematology, 1973
The subcellular distribution of platelet factor 3 and 4 (PF‐3 and 4) activity has been determined in sucrose gradient fractions of platelet homogenates. The distribution patterns were influenced by the homogenization technique (blendor or pestle) and the method of calculation (total activity or per mg protein).The bulk PF‐3 activity was present in ...
H J, Day, H, Stormorken, H, Holmsen
openaire   +2 more sources

Platelet heparin-neutralizing factor (platelet factor 4).

Thrombosis et diathesis haemorrhagica, 1975
The heparin-neutralizing platelet factor (PF4) is released from platelets under the influence of inducers of aggregation and nucleotide-release in the form of a high-molecular weight complex. The heparin-neutralizing activity is carried by a basic protein of molecular weight 29,700, four of which combine with a proteoglycan carrier, which in turn ...
E F, Lüscher, R, Käser-Glanzman
openaire   +3 more sources

Platelet factor 4-induced TH1-Treg polarization suppresses antitumor immunity.

Science
The tumor microenvironment (TME) contains a number of immune-suppressive cells such as T helper 1-polarized regulatory T cells (TH1-Treg cells). However, little is known about the mechanism behind the abundant presence of TH1-Treg cells in the TME.
Ayumi Kuratani, Masaaki Okamoto, K. Kishida, D. Okuzaki, Miwa Sasai, S. Sakaguchi, Hisashi Arase, Masahiro Yamamoto   +7 more
semanticscholar   +1 more source

Platelet factor 4 (PF 4) in septicaemia

Infection, 1988
The plasma concentrations of platelet factor 4 were measured in ten patients with septicaemia. In the acute phase the platelet factor 4 values were elevated (27.1 +/- 20.1 ng/ml; mean +/- SD; normal values 4.7 +/- 1.2 ng/ml), and declined significantly after treatment with antibiotics and surgical therapy, respectively (10.6 +/- 7.3 ng/ml; p less than ...
R, Lorenz, M, Brauer
openaire   +2 more sources

Effect of Platelet-Activating Factor and Platelet Factor 4 on Eosinophil Adhesion

International Archives of Allergy and Immunology, 2009
The effect of platelet-activating factor (PAF) and platelet factor 4 (PF4) on the adhesion of isolated human eosinophils or eosinophilic cell lines (EoL-1, EoL-3) was examined. Both PAF and PF4 augmented eosinophil adhesion to plates coated with AB plasma or recombinant soluble intercellular adhesion molecule-1 (r-sICAM-1).
N, Hayashi, J, Chihara, Y, Kobayashi, T, Kakazu, D, Kurachi, T, Yamamoto, S, Nakajima   +6 more
openaire   +2 more sources

Platelet factor 4 antigen in megakaryocytes

Thrombosis Research, 1980
The localization of platelet factor 4 (PF4) in the megakaryocyte has been determined by indirect immunofluorescent studies using monospecific rabbit antibody to human PF4. Also, specific staining has demonstrated that platelets in peripheral blood contain PF4 antigen. Absorption studies established that the staining was specific for PF4.
R, Ryo, R T, Proffitt, M E, Poger, R, O'Bear, T F, Deuel   +4 more
openaire   +2 more sources

Inactivation of Platelet Factor 4 in Plasma

Scandinavian Journal of Haematology, 1972
Some factors, influencing the stability of platelet factor 4 (PF‐4) and of protamine in human plasma were investigated. PF‐4 and protamine were slowly inactivated in normal citrated plasma, but were stable when equivalent amounts of heparin were present. Plasmin enhanced the speed of inactivation.
C, Eika, H C, Godal
openaire   +2 more sources