Results 231 to 240 of about 2,127,148 (291)

Platelet Factor 4: An Inhibitor of Collagenase

Science, 1978
Human platelet factor 4 (PF4) is known to bind to heparin and inhibit its anticoagulant effect. This factor also inhibits the enzyme collagenase derived from cultured human skin and collagenase extracted from human granulocytes. The addition of heparin to the PF4-collagenase assay system has no effect on the observed inhibition of collagenase. Thus PF4
J, Hiti-Harper, H, Wohl, E, Harper
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Circular dichroism of platelet factor 4

Archives of Biochemistry and Biophysics, 1988
The circular dichroism of platelet factor 4 was investigated and it was found to contain 15% alpha-helix, 25% beta-structure, and the rest of the molecule in unordered conformation. In the presence of heparin, no change in the circular dichroism was observed, suggesting no significant changes in the secondary structure of platelet factor 4 when heparin
G B, Villanueva, N, Allen, D, Walz
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Megakaryocytic Leukemia and Platelet Factor 4

Leukemia & Lymphoma, 1992
The de novo megakaryocytic leukemia fulfilling the FAB criteria is still an uncommonly recognized variant of acute leukemia. Many studies have shown that the megakaryocytic leukemic events may occur at a pluripotent stem cell level and clinical observations reveal that the megakaryocytic leukemias are diverse entities.
R, Ryo, M, Yasunaga, K, Saigo, N, Yamaguchi   +3 more
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Platelet factor 4 release from the platelets stored in platelet concentrates

Transfusion, 1985
Many consider that granular components of platelets should remain intact during storage of platelet concentrates (PCs) in order to participate in hemostasis when infused. The present investigations were done to determine factors affecting the release of an alpha‐granular component, platelet factor 4 (PF‐4), from platelets stored as PCs.
T, Shimizu, Y, Ishikawa, Y, Morishima, T, Fukuda, K, Kato   +4 more
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The Control of Angiogenesis and Tumor Invasion by Platelet Factor-4 and Platelet Factor-4-Derived Molecules

Seminars in Thrombosis and Hemostasis, 2004
Platelet factor-4 (PF-4) is an ELR-negative chemokine that exhibits antiangiogenesis properties. PF-4 inhibits endothelial cell proliferation and migration, angiogenesis in vitro and in vivo, and tumor growth. However, tumor cells are not directly inhibited by PF-4.
Andreas, Bikfalvi, Guillermo, Gimenez-Gallego   +1 more
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Inhibition of contact activation by platelet factor 4

Thrombosis Research, 1980
The contact activation of FXII by dextran sulphate (DS, MW 500,000) has been shown to be inhibited by platelet factor 4 (PF4). Plasma was prepared from blood taken with EDTA, theophylline and PGE1. Contact activation was initiated by the addition of an equal volume of DS (10μg/ml) and incubating at 0° (8 min) or 37° (2 min).
M F, Scully, K, Weerasinghe, V V, Kakkar
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The prothrombotic potential of platelet factor 4

European Journal of Internal Medicine, 2010
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder initiated by heparin administration. It is caused by the formation of pathogenic antibodies to complexes of platelet factor-4 (PF4) and heparin on platelet surfaces that cause platelet activation, aggregation and thrombosis.
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Platelet Factor-4. Methods of Study

1972
“Platelet Factor-4” (PF-4) indicates one or more factors exhibiting several biological functions (for review, see ref.3), the best known of which is the ability of neutralizing the anti- clotting activity of heparin; PF-4 is also able to neutralise the anticlotting activity of some fibrinogen degradation products and to induce non-enzymatic ...
M B, Donati, M, Palester-Chlebowczyk, G, De Gaetano, J, Vermylen   +3 more
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Platelet Factor 4: An Inhibitor of Angiogenesis

Seminars in Thrombosis and Hemostasis, 2004
Platelet factor 4 (PF4) is an antiangiogenic ELR-negative chemokine. PF4 inhibits endothelial cell proliferation and migration and angiogenesis in vitro and in vivo. Three different mechanisms have been proposed to explain PF4's antiangiogenic effects.
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Platelet factor 4: a chemokine enigma

The International Journal of Biochemistry & Cell Biology, 2005
Platelet factor 4 (PF4) is a platelet alpha-granule protein sequenced over 25 years ago that is a founding member of the C-X-C chemokine family, yet its physiologic function has yet to be definitively established. Initial investigations focused on possible procoagulant roles for PF4 in platelet function and plasmatic coagulation.
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