Results 61 to 70 of about 620,646 (305)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile

Frontiers in Cardiovascular Medicine, 2022
BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis ...
Li Li, Li Li, Mark Roest, Yaqiu Sang, Yaqiu Sang, Jasper A. Remijn, Rob Fijnheer, Karel Smit, Dana Huskens, Dana Huskens, Jun Wan, Jun Wan, Bas de Laat, Bas de Laat, Joke Konings, Joke Konings   +15 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Evaluation of platelet activation parameters as quality markers for the stored platelets [PDF]

Journal of Medical Biochemistry, 2007
In order to investigate the potential use of platelets activation parameters as routine quality control indicators during liquid storage, 27 PC-BC units were kept at 22 oC for up to 5 days.
Subota Vesna, Vučetić Dušan, Balint Bela, Mijušković Zoran, Vojvodić Danilo, Pejović Janko, Mandić-Radić Slavka   +6 more
doaj  

Identification of 22 novel mutations in patients with Glanzmann's thrombasthenia [PDF]

, 2008
Glanzmann's thrombasthenia (GT) is an autosomal recessive inherited platelet function defect that characterized by reduction in, or absence of, platelet aggregation in response to multiple physiologic agonists. GT is characterized by normal platelet
Abdul Ethayathulla, Birendra Yadav, Firdos Ahmad, Meganathan Kannan, Rajive Kumar, Renu Saxena, Ved Choudhry   +6 more
core   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Impact of pneumatic tube vs. bicycle courier transport on platelet aggregation: influence of sex and diabetes

Frontiers in Medicine
AimPneumatic tube (PT) transport can impact platelet function, often altering platelet aggregation. Consequently, manual transport is frequently recommended to mitigate preanalytical effects on platelet function tests.
Anna Hohneck, Anna Hohneck, Elisabeth Kliemank, Elisabeth Kliemank, Simon Bach, Simon Bach, Sebastian Brings, Sebastian Brings, Lukas Seebauer, Lukas Seebauer, Mani Roshan, Mani Roshan, Zoltan Kender, Zoltan Kender, Stefan Kopf, Norbert Frey, Norbert Frey, Markus Zorn, Markus Zorn, Stefan M. Woerner, Stefan M. Woerner, Thomas Fleming, Thomas Fleming, Julia Szendroedi, Julia Szendroedi   +24 more
doaj   +1 more source

The interaction between preoperative platelet count and function and its relationship with postoperative bleeding in cardiac surgery

Platelets, 2017
Platelet function tests (PFTs) before cardiac surgery are predictive of postoperative bleeding and can guide a correct timing of surgery in patients under P2Y12 inhibitors. Thrombocytopenia affects PFT and may determine postoperative bleeding.
Marco Ranucci, Ekaterina Baryshnikova
doaj   +1 more source

Standard vs. Modified Antiplatelet Therapy Based on Thromboelastography With Platelet Mapping for Preventing Bleeding Events in Patients Undergoing Stent-Assisted Coil for a Ruptured Intracranial Aneurysm

Frontiers in Neurology, 2021
Background and Purpose: Stent-assisted coiling (SAC) of intracranial aneurysms is usually treated with antiplatelet therapy to reduce the risk of postoperative ischemic events.
Yuanshu Li, Xiaodong Zhang, Zongduo Guo, Ji Zhu, Rui Xu, Zhaohui He, Xiaochuan Sun   +6 more
doaj   +1 more source

Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers. [PDF]

, 2019
BACKGROUND: Ticagrelor is an oral P2Y12 inhibitor that is used with aspirin to reduce the risk of ischemic events among patients with acute coronary syndromes or previous myocardial infarction.
Arnold, Susan E., Bhatt, Deepak L., Jennings, Lisa K., Lee, John S., Mays, Michael C., Pollack, Charles V., Umstead, Bret R., Weitz, Jeffrey I., Xu, Sherry   +8 more
core   +1 more source