Results 71 to 80 of about 764,489 (264)

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

Impaired platelet function in Hermansky-Pudlak syndrome associated with novel mutations in HPS3, HPS6 and HPS8 genes [PDF]

We report three unrelated cases of Hermansky-Pudlak (HP) characterized by novel mutations in HPS3 (compound heterozygosity for c.1457G>A and c.1813G>T), HPS6 (homozygous c.210_211insGGGCC), and HPS8 (homozygous c.299dupC in BLOC1S3) genes. No spontaneous
Attanasio, Monica, Castaman, Giancarlo, Linari, Silvia, Pieri, Lisa, Salvianti, Francesca   +4 more
core   +1 more source

Static platelet adhesion, flow cytometry and serum TXB2 levels for monitoring platelet inhibiting treatment with ASA and clopidogrel in coronary artery disease: a randomised cross-over study [PDF]

, 2009
Background Despite the use of anti-platelet agents such as acetylsalicylic acid (ASA) and clopidogrel in coronary heart disease, some patients continue to suffer from atherothrombosis.
A Bryman, A von Ruecker, AC Eriksson, AC Eriksson, AC Eriksson, AC Eriksson, AC Eriksson, AD Michelson, AD Michelson, AL Frelinger 3rd, Andreas C Eriksson, Antiplatelet Trialists' Collaboration, Bo Hedbäck, CAPRIE Steering Committee, CP Cannon, D Lasne, D Moreau, DJ Angiolillo, F Violi, FL Fimognari, GH Rao, GH Rao, GJ Hankey, H Haubelt, J Graff, K Moshfegh, L Bonello, L Bonello, L Macchi, L Pizzulli, Lena Jonasson, M Hurlen, M Joner, MC Berndt, ML Rand, MS Sabatine, P Harrison, P Jaremo, Per A Whiss, PH Grewe, PJ Mason, RL Kinlough-Rathbone, S Nylander, S Sanderson, S Yusuf, SR Mehta, SR Steinhubl, T Kawasaki, TH Lundahl, TL Lindahl, Tomas L Lindahl, U Berglund, V Mustad, VL Serebruany, W Khovidhunkit, W Siess, ZM Chen   +56 more
core   +3 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Evaluating Resistance to Acetyl Salicylic Acid Using Platelet Function Test in Patients with Ischemic Stroke at Cipto Mangunkusumo Hospital [PDF]

, 2015
Aim: to identify the prevalence of laboratoric ASA resistance using platelet function tests in patients with ischemic stroke at Cipto Mangunkusumo Hospital and its associated factors.
Harris, Salim, Hermawan, Deddy, Kurniawan, M., Prihartono, Joedo   +3 more
core   +2 more sources

Skin calcium deposits in primary familial brain calcification: A novel potential biomarker

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Primary Familial Brain Calcification (PFBC) is a rare neurodegenerative disorder characterized by small vessel calcifications in the basal ganglia. PFBC is caused by pathogenic variants in different genes and its physiopathology is still largely unknown. Skin vascular calcifications have been detected in single PFBC cases, suggesting
Aron Emmi, Giulia Bonato, Aleksandar Tushevski, Cinzia Bertolin, Francesco Cavallieri, Andrea Porzionato, Angelo Antonini, Leonardo Salviati, Miryam Carecchio   +8 more
wiley   +1 more source

Density-Functional Theory Study of Hydrogen Induced Platelets (HIPs) in Silicon [PDF]

, 2011
In this contribution we present the results of Density-Functional Theory (DFT) calculations of platelets as modelled by infinite planar arrangements of hydrogen atoms and vacancies in (100) planes of silicon. From the observation of the relaxed platelet structures and the comparison of their energy with the one of hydrogen molecules dissolved in ...
arxiv   +1 more source

Investigations into effects of 12-lipoxygenase and NADPH oxidase on platelet activity, and influences of dietary dark chocolate [PDF]

, 2012
PhDPlatelets play a pivotal role in both normal hemostasis and pathological bleeding and importantly also contribute to the development of atherothrombosis.
Zain, Zetty Nadia Mohd
core  

High platelet reactivity in patients with acute coronary syndromes undergoing percutaneous coronary intervention: Randomised controlled trial comparing prasugrel and clopidogrel [PDF]

, 2015
Background: Prasugrel is more effective than clopidogrel in reducing platelet aggregation in acute coronary syndromes. Data available on prasugrel reloading in clopidogrel treated patients with high residual platelet reactivity (HRPR) i.e.
76-87 Ferri, A1 Bellemain-Appaix, Athanasios Karathanos, Azfar Zaman, CD Payne, Christian W. Hamm, D Alexopoulos, D Alexopoulos, DJ Angiolillo, Elli Tavlaki, F Stimpfle, G Montalescot, G Montalescot, G Parodi, G1 Sardella, GW Stone, Hugo ten Cate, Jean Booth, JL1 Mega, JP Collet, JP Loh, JT Brandt, Karin Müller, L Bonello, M Laine, Marcus Flather, Meinrad Gawaz, Michal Droppa, Miles Dalby, MJ Price, Monica Yanez-Lopez, ofEikelboom JW Paread, Ph. Gabriel Steg, R Piccolo, R1 Mehran, Rod H. Stables, S Windecker, SD Wiviott, SD Wiviott, Simon J. Davidson, T Geisler, T Geisler, Tobias Geisler, US Tantry, Winston Banya   +44 more
core   +3 more sources

ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective We performed a pilot screen to assess the utility of the NULISA™ (Nucleic‐acid‐Linked Immuno‐Sandwich Assay) platform in the identification of amyotrophic lateral sclerosis (ALS) biomarkers. Methods Plasma from 86 individuals (48 ALS, 18 asymptomatic C9orf72 repeat expansion carriers (AsymC9), and 20 healthy controls) was analyzed ...
Eleanor V. Thomas, Changee Han, Woo Jae Kim, Seneshaw Asress, Yingjie Li, Jennifer A. Taylor, Marla Gearing, Christina N. Fournier, Zachary T. McEachin, Nicholas T. Seyfried, Jonathan D. Glass   +10 more
wiley   +1 more source