Results 61 to 70 of about 7,899,636 (253)

Investigation of the contribution of an underlying platelet defect in women with unexplained heavy menstrual bleeding

Platelets, 2019
Heavy menstrual bleeding (HMB) is often undiagnosed in women and can cause discomfort and distress. A haemostatic cause for excessive bleeding is often not routinely investigated and can lead to hysterectomy at an early age.
Gillian C. Lowe, Roksana Fickowska, Rashid Al Ghaithi, Annabel Maclachlan, Paul Harrison, Will Lester, Steve P. Watson, Bethan Myers, Justin Clark, Neil V. Morgan   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

PSYNDEX Tests Review für FTF-W - FRANKFURTER TESTS FÜR FÜNFJÄHRIGE - WORTSCHATZ

, 1982
This is a PSYNDEX Tests Review of FTF-W - FRANKFURTER TESTS FÜR FÜNFJÄHRIGE - WORTSCHATZ. PSYNDEX Tests Reviews are written in German and describe and evaluate psychological and educational tests used in the German-speaking countries.
Raatz, Ulrich
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Platelet function testing: dead or alive [PDF]

Journal of Thrombosis and Haemostasis, 2018
Essentials Pharmacodynamic response to antiplatelet medication is heterogeneous. Platelet reactivity to dual antiplatelet therapy was analyzed by three platelet function assays. The prevalence of high and low platelet reactivity differed significantly between assays.
Helten, C., Naguib, D., Dannenberg, L., Pöhl, M., Ayhan, A., Hohlfeld, T., Levkau, Bodo, Kelm, M., Zeus, T., Polzin, A.   +9 more
openaire   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

PSYNDEX Tests Review für TRR 1 - TESTS ZU RECHNEN UND RAUMLEHRE 1

, 1984
This is a PSYNDEX Tests Review of TRR 1 - TESTS ZU RECHNEN UND RAUMLEHRE 1. PSYNDEX Tests Reviews are written in German and describe and evaluate psychological and educational tests used in the German-speaking countries.
Proekel, Gerhard
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

PSYNDEX Tests Review für FTF-M - FRANKFURTER TESTS FÜR FÜNFJÄHRIGE - MENGEN

, 1982
This is a PSYNDEX Tests Review of FTF-M - FRANKFURTER TESTS FÜR FÜNFJÄHRIGE - MENGEN. PSYNDEX Tests Reviews are written in German and describe and evaluate psychological and educational tests used in the German-speaking countries.
Raatz, Ulrich
core   +1 more source

Platelet function testing in uraemic patients

Hematology, 2008
Chronic renal failure (CRF) is associated with excessive bleeding for a variety of reasons. Platelet dysfunction is probably the most consistent and important feature, particularly platelet-platelet and platelet-vessel wall interactions. The skin bleeding time (SBT) is the best established predictor of bleeding in uraemic patients but suffers from poor
Shir-Jing, Ho, Rosalie, Gemmell, Timothy A, Brighton   +2 more
openaire   +2 more sources